Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Sara Asimus"'
Autor:
Vibeke Backer, Mahdi Hashemi, Sofia Necander, Malin Aurell, Piotr Kuna, Ziad Taib, David J. Keeling, Robert L. Coffman, Robert Palmér, Fanyi Jiang, Sara Asimus, Stephen Delaney, Ioannis Psallidas, Katerina Pardali, Katarina Korsback, Joachim Almquist, Per Gustafson, Tariq Sethi, Sam Jackson
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 203:296-306
Rationale: To examine the potential of TLR9 (Toll-like receptor 9) activation to modulate the type 2 immune response in asthma.Objectives: To evaluate efficacy and safety of AZD1419, an inhaled TLR...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84412c619305c6b024e21c1e75b3f234
https://doi.org/10.1164/rccm.202001-0133oc
https://doi.org/10.1164/rccm.202001-0133oc
Autor:
John Mo, David J. Keeling, Robert Palmér, Marita Olsson, Christina Lundin, Muir Russell, Rikard Pehrson, Henrik Forsman, David Close, Sara Asimus, Sara Carlert, Muna Albayaty
Publikováno v:
Br J Clin Pharmacol
AIMS: Retinoic acid‐related orphan receptor γ (RORγ), a master regulator of T‐helper 17 (Th17) cell function and differentiation, is an attractive target for treatment of Th17‐driven diseases. This first‐in‐human study aimed to investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbdd2e76debb98eb7de0a303f2a593fc
https://doi.org/10.1111/bcp.14253
https://doi.org/10.1111/bcp.14253
Autor:
Krishna Tulasi Kirla, Szilárd Nemes, Joanne Betts, Cecilia Kristensson, John Mo, Sara Asimus, Muhammad Waqas Sadiq, Elke Redlich, Thomas Koernicke, Rainard Fuhr, Wayne Brailsford, Christina Keen, Anette Hagberg, Jukka Mäenpää
Publikováno v:
Respiratory medicine. 191
Diffusing capacity for carbon monoxide (DLCO) was measured in a phase I single ascending dose study after inhalation of AZD8154 or placebo in healthy participants at baseline (DLCO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4716f829706706e8dea5cf41e8916957
https://pubmed.ncbi.nlm.nih.gov/34879298
https://pubmed.ncbi.nlm.nih.gov/34879298
Autor:
Cecilia Kristensson, Jukka Mäenpää, Rainard Fuhr, Wayne Brailsford, Thomas Körnicke, Tina Jellesmark Jensen, Mahdi Hashemi, Joanne Betts, Sofia Necander, Julia Jonsson, Anette Hagberg, Szilard Nemes, Rebecca Fransson, Maria G. Belvisi, Muhammad Waqas Sadiq, Sara Asimus, Christina Keen
Publikováno v:
British journal of clinical pharmacologyREFERENCES. 88(1)
Aims This 3-part, randomised, phase 1 first-in-human study (NCT03436316) investigated the safety, tolerability and pharmacokinetics (PK) of AZD8154, a dual phosphoinositide 3-kinase (PI3K) γδ inhibitor developed as a novel inhaled anti-inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4524abc8321a099d65c5d5ca89c1ae66
https://pubmed.ncbi.nlm.nih.gov/34182611
https://pubmed.ncbi.nlm.nih.gov/34182611
Autor:
Per Gustafson, Katarina Korsback, David J. Keeling, Joachim Almquist, Tariq Sethi, Ziad Taib, Mahdi Hashemi, Ioannis Psallidas, Robert Palmér, Sara Asimus, Katerina Pardali, Sofia Necander, Stephen Delaney, Malin Aurell
Publikováno v:
Airway pharmacology and treatment.
Introduction: The Phase 2a INCONTRO trial (NCT02898662) is a unique clinical trial that followed eosinophilic, moderate-to-severe asthma patients for up to 10 months after withdrawal of maintenance therapy. The primary endpoint of the trial – the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3421eebbb2a8f6b5ced82fd72c39c739
https://doi.org/10.1183/13993003.congress-2020.2278
https://doi.org/10.1183/13993003.congress-2020.2278
Autor:
Cecilia Kristensson, Jukka Mäenpää, Christina Keen, Szilard Nemes, Joanne Betts, T. Koernicke, T. Jellesmark Jensen, Rainard Fuhr, A. Hagberg, Sofia Necander, Sara Asimus, W.M. Sadiq, Wayne Brailsford
Publikováno v:
B31. ASTHMA CLINICAL TRIALS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93b0d5bf13fc130b8c24c3dfc777dfd5
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a3022
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a3022
Autor:
Paul S. Jansson, Rikard Pehrson, Tove Hegelund-Myrbäck, Annika Borde, Sara Asimus, Danen Cunoosamy, Naimish Patel, Sofia Lundin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 365:567-572
Inhaled drugs generally aim to drive a local pharmacological effect in lung, at the same time minimizing systemic exposure, in order to obtain efficacy in lung disease without unwanted systemic effects. Here, we demonstrate that inhaled delivery of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d625f4fee460e456fa1038d77af17ca
https://doi.org/10.1124/jpet.117.246132
https://doi.org/10.1124/jpet.117.246132
Autor:
Barry J. Make, Robert Palmér, Graham W. Clarke, Robert A. Wise, Stephen I. Rennard, Sara Asimus, Nisha Kurian, Tove Hegelund-Myrbäck, Katarina Korsback, Malin Fagerås, Danen Cunoosamy, Paul S. Jansson, Steven Greenaway, Cecilia Kristensson, Eva Ersdal, Katerina Pardali, Naimish Patel, Leonard Siew, Mary N. Brown, Ziad Taib, Sofia Lundin
Publikováno v:
International Journal of COPD, Vol Volume 13, Pp 1009-1019 (2018)
International Journal of Chronic Obstructive Pulmonary Disease
International Journal of Chronic Obstructive Pulmonary Disease
Naimish R Patel,1,2 Danen M Cunoosamy,1 Malin Fagerås,1 Ziad Taib,1 Sara Asimus,1 Tove Hegelund-Myrbäck,1 Sofia Lundin,1 Katerina Pardali,1 Nisha Kurian,1 Eva Ersdal,1 Cecilia Kristensson,1 Katarina Korsback,1 Robert Palmér,1 Mary N Brown,3 Steven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc971bb0133335d290426b49c4940a2
https://www.dovepress.com/the-development-of-azd7624-for-prevention-of-exacerbations-in-copd-a-r-peer-reviewed-article-COPD
https://www.dovepress.com/the-development-of-azd7624-for-prevention-of-exacerbations-in-copd-a-r-peer-reviewed-article-COPD
Autor:
Sara Asimus, Muhammad Waqas Sadiq, Christina Keen, Cecilia Kristensson, Jukka Mäenpää, Wayne Brailsford, Rainard Fuhr, John Mo, Thomas Koernicke, Joanne Betts, Anette Hagberg
Publikováno v:
Monitoring airway disease.
Introduction: Measuring diffusing capacity of the lung for carbon monoxide (DLCO) facilitates the diagnosis, classification and monitoring of various lung diseases, and may also be used for safety signal detection in clinical drug development. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85ea1c9c31368be62c11fa39c39c53e9
https://doi.org/10.1183/13993003.congress-2019.pa2650
https://doi.org/10.1183/13993003.congress-2019.pa2650
Autor:
Muhammad Waqas Sadiq, Christina Keen, Anette Hagberg, Joanne Betts, Jukka Mäenpää, Wayne Brailsford, Thomas Koernicke, Barbara Valastro, Cecilia Kristensson, Sara Asimus, Rainard Fuhr
Publikováno v:
Airway pharmacology and treatment.
AZD8154 is an inhaled PI3Kgd inhibitor developed for treatment of asthma. This first in human study evaluate the safety, tolerability and PK of AZD8154 in healthy volunteers after inhalation of single ascending doses (Part 1) and characterized the sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25b7f2de45f189551d70a25796f105fc
https://doi.org/10.1183/13993003.congress-2019.pa4220
https://doi.org/10.1183/13993003.congress-2019.pa4220