Methods of Calpain Inhibition to Determine the Role of Calpains in Embryo Development in Amphibians

Autor: Ioanna, Antoniades, Anna, Charalambous, Neophytos, Christodoulou, Sara, Zanardelli, Paris A, Skourides

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1915

Calpains are a family of calcium-dependent intracellular cysteine proteases that regulate important physiological processes by substrate cleavage. Despite the fact that the role of calpains in cell migration and other processes has been extensively s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d9b5c81eca8ba414c2d3e1eb3b2ab823
https://pubmed.ncbi.nlm.nih.gov/30617809

Determining Temporal and Spatial Expression of Calpains in Amphibians

Autor: Neophytos Christodoulou, Sara Zanardelli, Ioanna Antoniades, Anna Charalambous, Paris A. Skourides

Publikováno v: Methods in Molecular Biology ISBN: 9781493989874

Calpains are a family of calcium-dependent intracellular cysteine proteases that regulate important physiological processes by substrate cleavage. Despite the fact that Calpains have been identified in the Xenopus genome, their expression patterns an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b74039136622d82b532a7dfdfef25a59
https://doi.org/10.1007/978-1-4939-8988-1_6

A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF

Autor: Michael Laffan, Alain Chion, Sara Zanardelli, Thomas A. J. McKinnon, Michelle Tseng, Evelyn Groot, Peter J. Lenting, David A. Lane

Publikováno v: Blood. 114:2819-2828

ADAMTS13 metalloprotease regulates the multimeric size of von Willebrand factor (VWF) by cleaving the Tyr1605-Met1606 bond in the VWF A2 domain. The mechanisms of VWF recognition by ADAMTS13 have yet to be fully resolved. Most studies have focused on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621a1162447e3cd9e81644070e8f28e2
https://doi.org/10.1182/blood-2009-05-224915

The central role of thrombin in hemostasis

Autor: Chan K. N. K. Chion, Sara Zanardelli, James T. B. Crawley, David A. Lane

Publikováno v: Journal of thrombosis and haemostasis : JTH. 5

Following vascular injury, blood loss is controlled by the mechanisms of hemostasis. During this process, the serine proteinase, thrombin, is generated both locally and rapidly at sites of vessel damage. It plays a pivotal role in clot promotion and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1272f12633f09f756f0da6a8b00334
https://pubmed.ncbi.nlm.nih.gov/17635715

Identification and computionally-based structural interpretation of naturally occuring variants of human protein C

Autor: Francesca Marino, Pasqualina D'Ursi, Ermanna Rovida, Sara Zanardelli, Elena M. Faioni, Gessica Fontana, Giancarlo Castaman, Giuliana Merati

Publikováno v: Human mutation 28 (2007): 345–355. doi:10.1002/humu.20445
info:cnr-pdr/source/autori:Ermanna Rovida 1, Giuliana Merati 2, Pasqualina D'Ursi 3, Sara Zanardelli 2, Francesca Marino 1, Gessica Fontana 4, GiancarloCastaman 5, Elena M. Faioni 4/titolo:Identification and computionally-based structural interpretation of naturally occuring variants of human protein C/doi:10.1002%2Fhumu.20445/rivista:Human mutation/anno:2007/pagina_da:345/pagina_a:355/intervallo_pagine:345–355/volume:28
info:cnr-pdr/source/autori:Rovida E; Merati G; D'Ursi P; Zanardelli S; Marino F; Fontana G; Castaman G; Faioni EM/titolo:Identification and computationally-based structural interpretation of naturally occurring variants of human protein C./doi:10.1002%2Fhumu.20445/rivista:Human mutation/anno:2007/pagina_da:345/pagina_a:355/intervallo_pagine:345–355/volume:28

Protein C (PC) is a key regulator of blood clotting and inflammation. Its inherited deficiency is associated with venous thromboembolism, and recombinant activated PC is currently used to increase survival in severe sepsis. The molecular basis of inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b27476a8e8451d128fb7236a52649f
https://publications.cnr.it/doc/323974