Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Sara, Verdura"'
Autor:
Elisabet Cuyàs, Stefano Pedarra, Sara Verdura, Miguel Angel Pardo, Roderic Espin Garcia, Eila Serrano-Hervás, Àngela Llop-Hernández, Eduard Teixidor, Joaquim Bosch-Barrera, Eugeni López-Bonet, Begoña Martin-Castillo, Ruth Lupu, Miguel Angel Pujana, Josep Sardanyès, Tomás Alarcón, Javier A. Menendez
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-17 (2024)
Abstract Fatty acid synthase (FASN)-catalyzed endogenous lipogenesis is a hallmark of cancer metabolism. However, whether FASN is an intrinsic mechanism of tumor cell defense against T cell immunity remains unexplored. To test this hypothesis, here w
Externí odkaz:
https://doaj.org/article/cf58d85bd0c34429bd80f33b1267b08a
Autor:
Javier A. Menendez, Elisabet Cuyàs, Jose Antonio Encinar, Travis Vander Steen, Sara Verdura, Àngela Llop‐Hernández, Júlia López, Eila Serrano‐Hervás, Sílvia Osuna, Begoña Martin‐Castillo, Ruth Lupu
Publikováno v:
Molecular Oncology, Vol 18, Iss 3, Pp 479-516 (2024)
The initial excitement generated more than two decades ago by the discovery of drugs targeting fatty acid synthase (FASN)‐catalyzed de novo lipogenesis for cancer therapy was short‐lived. However, the advent of the first clinical‐grade FASN inh
Externí odkaz:
https://doaj.org/article/d3a6d2c3332d4732a381d0b6a5d9a94b
Autor:
Barbara Schroeder, Travis Vander Steen, Ingrid Espinoza, Chandra M. Kurapaty Venkatapoorna, Zeng Hu, Fernando Martín Silva, Kevin Regan, Elisabet Cuyàs, X. Wei Meng, Sara Verdura, Aina Arbusà, Paula A. Schneider, Karen S. Flatten, George Kemble, Joan Montero, Scott H. Kaufmann, Javier A. Menendez, Ruth Lupu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021)
Abstract Inhibitors of the lipogenic enzyme fatty acid synthase (FASN) have attracted much attention in the last decade as potential targeted cancer therapies. However, little is known about the molecular determinants of cancer cell sensitivity to FA
Externí odkaz:
https://doaj.org/article/aa72c25e3f5c4af1a2822139760db5bf
Autor:
Octavio A. Romero, Andrea Vilarrubi, Juan J. Alburquerque-Bejar, Antonio Gomez, Alvaro Andrades, Deborah Trastulli, Eva Pros, Fernando Setien, Sara Verdura, Lourdes Farré, Juan F. Martín-Tejera, Paula Llabata, Ana Oaknin, Maria Saigi, Josep M. Piulats, Xavier Matias-Guiu, Pedro P. Medina, August Vidal, Alberto Villanueva, Montse Sanchez-Cespedes
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
SMARCA4 is commonly inactivated in lung and ovarian cancers. Here the authors show that SMARCA4-deficient tumours have significantly reduced levels of the histone demethylases KDM6s and a strong dependency on these demethylases for tumour growth, so
Externí odkaz:
https://doaj.org/article/c8c005713fd44b6bbb0151fbe7d89bec
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Metabolism can directly drive or indirectly enable an aberrant chromatin state of cancer cells. The physiological and molecular principles of the metabolic link to epigenetics provide a basis for pharmacological modulation with the anti-diabetic bigu
Externí odkaz:
https://doaj.org/article/606f28326ee14f8b9a3c23043e8cc37f
Autor:
Joaquim Bosch-Barrera, Ariadna Roqué, Eduard Teixidor, Maria Carmen Carmona-Garcia, Aina Arbusà, Joan Brunet, Begoña Martin-Castillo, Elisabet Cuyàs, Sara Verdura, Javier A. Menendez
Publikováno v:
Pharmaceuticals, Vol 15, Iss 1, p 19 (2021)
COVID-19 pathophysiology is caused by a cascade of respiratory and multiorgan failures arising, at least in part, from the SARS-CoV-2-driven dysregulation of the master transcriptional factor STAT3. Pharmacological correction of STAT3 over-stimulatio
Externí odkaz:
https://doaj.org/article/8b7ee1d49b544476a47992a5e8eac169
Autor:
Sara Verdura, Elisabet Cuyàs, Verónica Ruiz-Torres, Vicente Micol, Jorge Joven, Joaquim Bosch-Barrera, Javier A. Menendez
Publikováno v:
Pharmaceuticals, Vol 14, Iss 6, p 559 (2021)
The flavonolignan silibinin, the major bioactive component of the silymarin extract of Silybum marianum (milk thistle) seeds, is gaining traction as a novel anti-cancer therapeutic. Here, we review the historical developments that have laid the groun
Externí odkaz:
https://doaj.org/article/23be91c15ee24c6eb56bdf2b44dd6fbe
Publikováno v:
OncoImmunology, Vol 8, Iss 10 (2019)
The development of a single immuno-metabolic adjuvant capable of modulating, in the appropriate direction and intensity, the complex antagonistic and symbiotic interplays between tumor cells, immune cells, and the gut microbiota may appear pharmacolo
Externí odkaz:
https://doaj.org/article/bc8541831dc8455b8c5891d4f5d61214
Autor:
Elisabet Cuyàs, Maria Buxó, Maria José Ferri Iglesias, Sara Verdura, Sonia Pernas, Joan Dorca, Isabel Álvarez, Susana Martínez, Jose Manuel Pérez-Garcia, Norberto Batista-López, César A. Rodríguez-Sánchez, Kepa Amillano, Severina Domínguez, Maria Luque, Idoia Morilla, Agostina Stradella, Gemma Viñas, Javier Cortés, Jorge Joven, Joan Brunet, Eugeni López-Bonet, Margarita Garcia, Samiha Saidani, Xavier Queralt Moles, Begoña Martin-Castillo, Javier A. Menendez
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Background: The minor allele (C) of the single-nucleotide polymorphism (SNP) rs11212617, located near the ataxia telangiectasia mutated (ATM) gene, has been associated with an increased likelihood of treatment success with metformin in type 2 diabete
Externí odkaz:
https://doaj.org/article/d2338fd8195c45919755b3df06f89a20
Autor:
Montse Sanchez-Cespedes, Suvi Savola, Elisabeth Brambilla, Luca Roz, Alberto Villanueva, David Sidransky, Agustin Vidal, Enric Condom, Julian Carretero, Juan Pablo Rodrigo, Maria Dolores Chiara, Sylvie Lantuejoul, Federica Facchinetti, Ilse Zondervan, Sara Verdura, Ester Bonastre
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee1732894d3483be3ba29191ba67eaf
https://doi.org/10.1158/0008-5472.22406970
https://doi.org/10.1158/0008-5472.22406970
