Functional studies on the IBD susceptibility gene IL23R implicate reduced receptor function in the protective genetic variant R381Q.

Autor: Svetlana Pidasheva, Sara Trifari, Anne Phillips, Jason A Hackney, Yan Ma, Ashley Smith, Sue J Sohn, Hergen Spits, Randall D Little, Timothy W Behrens, Lee Honigberg, Nico Ghilardi, Hilary F Clark

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e25038 (2011)

Genome-wide association studies (GWAS) in several populations have demonstrated significant association of the IL23R gene with IBD (Crohn's disease (CD) and ulcerative colitis (UC)) and psoriasis, suggesting that perturbation of the IL-23 signaling p

Externí odkaz: https://doaj.org/article/3ee599140d13470ebc2200332b8af4f1

Exhaustion-associated regulatory regions in CD8

Autor: Giuliana P, Mognol, Roberto, Spreafico, Victor, Wong, James P, Scott-Browne, Susan, Togher, Alexander, Hoffmann, Patrick G, Hogan, Anjana, Rao, Sara, Trifari

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 114(13)

Cancer cells can be recognized and attacked by CD8+ cytolytic T cells, but tumor-infiltrating T cells often become functionally incompetent (“exhausted”) and fail to destroy tumor cells. We show that T-cell exhaustion requires antigen recognition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::053a79b680e70c953895b7963c40b177
https://pubmed.ncbi.nlm.nih.gov/28283662

MicroRNA-directed program of cytotoxic CD8 + T-cell differentiation

Autor: Sara Trifari, Runqiang Chen, Gustavo J. Martinez, Anjana Rao, Matthew E. Pipkin, Jed A. Bassein, Hozefa S. Bandukwala, Tarmo Äijö

Publikováno v: Proceedings of the National Academy of Sciences. 110:18608-18613

Acquisition of effector properties is a key step in the generation of cytotoxic T lymphocytes (CTLs). Here we show that inflammatory signals regulate Dicer expression in CTLs, and that deletion or depletion of Dicer in mouse or human activated CD8(+)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::536bec1ef807f460d19b4c95c7269a8b
https://doi.org/10.1073/pnas.1317191110

Approaches to Detect microRNA Expression in T Cell Subsets and T Cell Differentiation

Autor: Silvia, Monticelli, Tarmo, Äijö, Sara, Trifari

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1514

MicroRNAs (miRNAs) are crucial components of the molecular networks regulating differentiation and responses of T lymphocytes in health and disease. It is therefore essential to rely on robust methods of qualitative and quantitative investigation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b06dce9f4ab94eb7608e34d1068cc6f
https://pubmed.ncbi.nlm.nih.gov/27787800

Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells

Autor: Charles D. Kaplan, Natasha K Crellin, Tom Cupedo, Hergen Spits, Sara Trifari

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine, 207(2), 281-290. Rockefeller University Press
Journal of experimental medicine, 207(2), 281-290. Rockefeller University Press

Lymphoid tissue inducer (LTi) cells are required for lymph node formation during fetal development, and recent evidence implies a role in mucosal immunity in the adult. LTi cells share some phenotypic features of conventional natural killer (NK; cNK)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0601a497eda5a9a143cd8f20814707
http://europepmc.org/articles/PMC2822607