Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Sara, Sigismund"'
Autor:
Paloma García Casas, Michela Rossini, Linnea Påvénius, Mezida Saeed, Nikita Arnst, Sonia Sonda, Tânia Fernandes, Irene D’Arsiè, Matteo Bruzzone, Valeria Berno, Andrea Raimondi, Maria Livia Sassano, Luana Naia, Elisa Barbieri, Sara Sigismund, Patrizia Agostinis, Mattia Sturlese, Barbara A. Niemeyer, Hjalmar Brismar, Maria Ankarcrona, Arnaud Gautier, Paola Pizzo, Riccardo Filadi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Membrane contact sites (MCSs) are hubs allowing various cell organelles to coordinate their activities. The dynamic nature of these sites and their small size hinder analysis by current imaging techniques. To overcome these limitations, we h
Externí odkaz:
https://doaj.org/article/0b6b5bb0acb9468497829472faf67a2f
Autor:
Mariadomenica Lupi, Daniele Avanzato, Stefano Confalonieri, Flavia Martino, Rosa Pennisi, Emanuela Pupo, Valentina Audrito, Stefano Freddi, Giovanni Bertalot, Francesca Montani, Bronislava Matoskova, Sara Sigismund, Pier Paolo Di Fiore, Letizia Lanzetti
Publikováno v:
Cell Death and Disease, Vol 15, Iss 9, Pp 1-14 (2024)
Abstract Metabolic plasticity is a hallmark of cancer, and metabolic alterations represent a promising therapeutic target. Since cellular metabolism is controlled by membrane traffic at multiple levels, we investigated the involvement of TBC1 domain-
Externí odkaz:
https://doaj.org/article/43797c9071184cd3a3653f520685ea16
Autor:
Deborah Mesa, Elisa Barbieri, Andrea Raimondi, Stefano Freddi, Giorgia Miloro, Gorana Jendrisek, Giusi Caldieri, Micaela Quarto, Irene Schiano Lomoriello, Maria Grazia Malabarba, Arianna Bresci, Francesco Manetti, Federico Vernuccio, Hind Abdo, Giorgio Scita, Letizia Lanzetti, Dario Polli, Carlo Tacchetti, Paolo Pinton, Massimo Bonora, Pier Paolo Di Fiore, Sara Sigismund
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract One open question in the biology of growth factor receptors is how a quantitative input (i.e., ligand concentration) is decoded by the cell to produce specific response(s). Here, we show that an EGFR endocytic mechanism, non-clathrin endocyt
Externí odkaz:
https://doaj.org/article/1aea93372b324f868e8be4a452c68516
Autor:
Roberta Pascolutti, Veronica Algisi, Alexia Conte, Andrea Raimondi, Mithun Pasham, Srigokul Upadhyayula, Raphael Gaudin, Tanja Maritzen, Elisa Barbieri, Giusi Caldieri, Chiara Tordonato, Stefano Confalonieri, Stefano Freddi, Maria Grazia Malabarba, Elena Maspero, Simona Polo, Carlo Tacchetti, Volker Haucke, Tom Kirchhausen, Pier Paolo Di Fiore, Sara Sigismund
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114970- (2024)
Externí odkaz:
https://doaj.org/article/b2ea199df0684449960748dac3c283bb
Autor:
Irene Schiano Lomoriello, Giovanni Giangreco, Claudia Iavarone, Chiara Tordonato, Giusi Caldieri, Gaetana Serio, Stefano Confalonieri, Stefano Freddi, Fabrizio Bianchi, Stefania Pirroni, Giovanni Bertalot, Giuseppe Viale, Davide Disalvatore, Daniela Tosoni, Maria Grazia Malabarba, Andrea Disanza, Giorgio Scita, Salvatore Pece, Brian K. Pilcher, Manuela Vecchi, Sara Sigismund, Pier Paolo Di Fiore
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
It is unclear if genetic alterations in endocytic proteins play a causal role in high incidence human cancers. Here, the authors report the oncogenic role of Epsin3 (EPN3) in breast cancer, and show EPN3 to drive tumorigenesis through induction of a
Externí odkaz:
https://doaj.org/article/13d80ead99db4faeaae47bea7bd4c693
Publikováno v:
Open Biology, Vol 10, Iss 3 (2020)
Mitotic progression is orchestrated by morphological and mechanical changes promoted by the coordinated activities of the microtubule (MT) cytoskeleton, the actin cytoskeleton and the plasma membrane (PM). MTs assemble the mitotic spindle, which a
Externí odkaz:
https://doaj.org/article/f1a4a90be2c74299b0d960e1c7650f3c
Publikováno v:
Molecular Oncology, Vol 12, Iss 1, Pp 3-20 (2018)
The physiological function of the epidermal growth factor receptor (EGFR) is to regulate epithelial tissue development and homeostasis. In pathological settings, mostly in lung and breast cancer and in glioblastoma, the EGFR is a driver of tumorigene
Externí odkaz:
https://doaj.org/article/e5bc06a6ca424042abe909cf1e19bb8b
Autor:
Roberta Pascolutti, Veronica Algisi, Alexia Conte, Andrea Raimondi, Mithun Pasham, Srigokul Upadhyayula, Raphael Gaudin, Tanja Maritzen, Elisa Barbieri, Giusi Caldieri, Chiara Tordonato, Stefano Confalonieri, Stefano Freddi, Maria Grazia Malabarba, Elena Maspero, Simona Polo, Carlo Tacchetti, Volker Haucke, Tom Kirchhausen, Pier Paolo Di Fiore, Sara Sigismund
Publikováno v:
Cell Reports, Vol 27, Iss 10, Pp 3049-3061.e6 (2019)
Summary: Adaptor protein 2 (AP2) is a major constituent of clathrin-coated pits (CCPs). Whether it is essential for all forms of clathrin-mediated endocytosis (CME) in mammalian cells is an open issue. Here, we demonstrate, by live TIRF microscopy, t
Externí odkaz:
https://doaj.org/article/621ad877eaa14894b7e9f36e39fad5bd
Publikováno v:
Nature Reviews Molecular Cell Biology. 22:625-643
Endocytosis allows cells to transport particles and molecules across the plasma membrane. In addition, it is involved in the termination of signalling through receptor downmodulation and degradation. This traditional outlook has been substantially mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e314e3cec5bfe9bd213339827bf959fe
https://doi.org/10.1038/s41580-021-00375-5
https://doi.org/10.1038/s41580-021-00375-5
Autor:
Stefano Freddi, Irene Schiano Lomoriello, Alexia Conte, Sara Sigismund, Maura Poli, Elena Gammella, Gaetano Cairo, Alessandra Alberghini, Stefania Recalcati
Publikováno v:
Molecular Biology of the Cell. 32:98-108
The posttranslational regulation of transferrin receptor (TfR1) is largely unknown. We investigated whether iron availability affects TfR1 endocytic cycle and protein stability in HepG2 hepatoma cells exposed to ferric ammonium citrate (FAC). NH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4b2d3a69aa6fa75a83ebdf0ea7c79a
https://doi.org/10.1091/mbc.e20-02-0129
https://doi.org/10.1091/mbc.e20-02-0129