S-(4-Nitrobenzyl)-6-thioinosine (NBMPR) is Not a Selective Inhibitor of Equilibrative Nucleoside Transporters but Also Blocks Efflux Activity of Breast Cancer Resistance Protein

Autor: Lukas Cerveny, Ales Sorf, Frantisek Staud, Lucie Jirásková, Zuzana Ptackova, Anezka Lalinska, Sara Karbanova

Publikováno v: Pharmaceutical Research. 37

S-(4-Nitrobenzyl)-6-thioinosine (NBMPR) is routinely used at concentrations of 0.10 μM and 0.10 mM to specifically inhibit transport of nucleosides mediated by equilibrative nucleoside transporters 1 (ENT1) and 2 (ENT2), respectively. We recently sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f79c39455d633d2ed3b4c04b26ad829
https://doi.org/10.1007/s11095-020-2782-5

Equilibrative Nucleoside Transporter 1 (ENT1

Autor: Lukas, Cerveny, Zuzana, Ptackova, Martina, Ceckova, Rona, Karahoda, Sara, Karbanova, Lucie, Jiraskova, Susan L, Greenwood, Jocelyn D, Glazier, Frantisek, Staud

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 46(11)

Abacavir is a preferred antiretroviral drug for preventing mother-to-child human immunodeficiency virus transmission; however, mechanisms of its placental transfer have not been satisfactorily described to date. Because abacavir is a nucleoside-deriv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fb8780a12428043ba5a1d65a43ca60f8
https://pubmed.ncbi.nlm.nih.gov/30097436

Equilibrative nucleoside transporter 1 (ENT1, SLC29A1) facilitates transfer of the antiretroviral drug abacavir across the placenta

Autor: Jocelyn D. Glazier, Lukas Cerveny, Rona Karahoda, Susan L. Greenwood, Martina Ceckova, Lucie Jirásková, Sara Karbanova, Frantisek Staud, Zuzana Ptackova

Publikováno v: Cerveny, L, Ptackova, Z, Ceckova, M, Karahoda, R, Karbanova, S, Jiraskova, L, Greenwood, S L, Glazier, J D & Staud, F 2018, ' Equilibrative nucleoside transporter 1 (ENT1, SLC29A1) facilitates transfer of the antiretroviral drug abacavir across the placenta ', Drug Metabolism and Disposition . https://doi.org/10.1124/dmd.118.083329

Abacavir is a preferred antiretroviral drug for preventing mother-to-child human immunodeficiency virus transmission; however, mechanisms of its placental transfer have not been satisfactorily described to date. Because abacavir is a nucleoside-deriv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae9fee1e8f5f2d8aaf1ebfec4a35e57
https://www.research.manchester.ac.uk/portal/en/publications/equilibrative-nucleoside-transporter-1-ent1-slc29a1-facilitates-transfer-of-the-antiretroviral-drug-abacavir-across-the-placenta(d82e1a51-94a7-4594-b907-a5604c6f460a).html

Role of nucleoside transporters in transplacental pharmacokinetics of nucleoside reverse transcriptase inhibitors zidovudine and emtricitabine

Autor: Frantisek Staud, Lukas Cerveny, Sara Karbanova, Lucie Jirásková, Susan L. Greenwood, Zuzana Ptackova, Martina Ceckova

Publikováno v: Placenta. 60

Introduction Zidovudine (AZT) and emtricitabine (FTC) are effective and well tolerated antiretroviral drugs, routinely used in the prevention of perinatal HIV transmission. However, precise mechanism(s) involved in their transfer from mother to fetus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e30eaaecac46cb7731d2fe114480f9a
https://pubmed.ncbi.nlm.nih.gov/29208244

The role of nucleoside transporters in entecavir transport across placenta

Autor: Lukas Cerveny, Frantisek Staud, Sara Karbanova

Publikováno v: Drug Metabolism and Pharmacokinetics. 34:S40

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35b9fd56e16391c4fc2e9cde6f092248
https://doi.org/10.1016/j.dmpk.2018.09.147