Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Sara, Ghorashian"'
Autor:
Macarena Oporto Espuelas, Saskia Burridge, Amy A. Kirkwood, Denise Bonney, Kelly Watts, Geoff Shenton, Katarzyna A. Jalowiec, Maeve A. O’Reilly, Claire Roddie, Anna Castleton, Katherine Clesham, Emma Nicholson, Rajesh Alajangi, Shilpa Prabhu, Lindsay George, Ben Uttenthal, Maria Gabelli, Lorna Neill, Caroline Besley, Sridhar Chaganti, Robert F. Wynn, Jack Bartram, Robert Chiesa, Giovanna Lucchini, Vesna Pavasovic, Anupama Rao, Kanchan Rao, Juliana Silva, Sujith Samarasinghe, Ajay Vora, Peter Clark, Michelle Cummins, David I. Marks, Persis Amrolia, Rachael Hough, Sara Ghorashian
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract CAR T-cell therapy has transformed relapsed/refractory (r/r) B-cell precursor acute lymphoblastic leukaemia (B-ALL) management and outcomes, but following CAR T infusion, interventions are often needed. In a UK multicentre study, we retrospe
Externí odkaz:
https://doaj.org/article/1e1c7d0bb80d4261a46effd3f77c1a63
Autor:
Peter Bader, Anna Alsonso, Andishe Attarbaschi, Nicole Bodmer, Halvard Bonig, Saskia Burridge, Jean-Pierre Bourquin, Veit Bücklein, Gunnar Cario, Macarena Oporto Espuelas, Tobias Feuhtinger, Anna Fuereder, Julia Hauer, Martin Hutter, Krzysztof Kałwak, Annette Künkele, Roland Meisel, Monika Mielcarek-Siedziuk, Ingo Müller, Sara Napolitano, Olaf Penack, Susana Rives, Claudia Rossig, Arend von Stackelberg, Andrea Jarisch, Sara Ghorashian, Adriana Balduzzi
Publikováno v:
HemaSphere, Vol 7, p e239539e (2023)
Externí odkaz:
https://doaj.org/article/0de9358a98e24532b581f74cf2758208
Autor:
Soragia Athina Gkazi, Emma Gravett, Carla Bautista, Jack Bartram, Sara Ghorashian, Stuart Paul Adams
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7573 (2022)
Chimeric antigen receptor (CAR) T cell therapy is an innovative immunotherapy for treating cancers in both children and adults with proven utility in numerous clinical trials. Significantly, some CAR T cell therapies have now been approved by relevan
Externí odkaz:
https://doaj.org/article/b1adc59154f64396acc46a4121295d10
Autor:
Karl S. Peggs, Sarah J. Albon, Macarena Oporto Espuelas, Catherine Irving, Rachel Richardson, Joan Casanovas-Company, Rebecca Wallace, Aleks Guvenel, Sara Ghorashian, Angela Collura, Meera Subramaniyam, Barry Flutter, Bilyana Popova, Fernanda Castro, Andre Lopes, Kim Champion, Oliver Schofield, Laura Clifton-Hadley, Thomas Taylor, Maria Farrell, Stuart Adams, Kimberly C. Gilmour, Stephen Mackinnon, Eleni Tholouli, Persis J. Amrolia
Publikováno v:
Cytotherapy. 25:82-93
Delayed immune reconstitution is a major challenge after matched unrelated donor (MUD) stem cell transplant (SCT). In this randomized phase 2 multi-center trial, Adoptive Immunotherapy with CD25/71 allodepleted donor T cells to improve immunity after
Autor:
Khushnuma Mullanfiroze, Arina Lazareva, Jan Chu, Lindsey Williams, Saskia Burridge, Juliana Silva, Robert Chiesa, Kanchan Rao, Giovanna Lucchini, Sara Ghorashian, Maeve O’Reilly, Ben Carpenter, Victoria Grandage, Rachael Hough, Claire Roddie, Persis J. Amrolia
Publikováno v:
Blood Advances. 6:4715-4718
Autor:
Angus Hodder, Avijeet K Mishra, Katherine Clesham, Susan Baird, Kaljit Bhuller, Ismail Bisho, Denise Bonney, Anna Castleton, Michelle Cummins, Emmy Dickens, Lindsay George, Sara Ghorashian, Brenda Gibson, Chris Hasley, Nicholas Heaney, Rachael E Hough, Danielle Ingham, Galina Jigoulina, Katherine Lindsay, Donna Lancaster, Majid Madni, Andrea Malone, Bethany Mitchell, Anthony V. Moorman, John Moppett, Vanessa McLelland, Jayashree Motwani, Emma Nicholson, Caroline Osborne, Katharine Patrick, Lamia Samrin, Sanjay Tewari, Indu Rakesh Thakur, Sujith Samarasinghe, Ajay Vora, David O'Connor
Publikováno v:
Blood. 140:3268-3270
Autor:
Macarena Oporto Espuelas, Saskia Burridge, Denise Bonney, Kelly Watts, Claire Roddie, Maeve A O'Reilly, Geoff Shenton, John A Snowden, Caroline Furness, Katarzyna Aleksandra Aleksandra Jalowiec, Lorna Neill, Katherine Clesham, Emma Nicholson, Anna Castleton, Amit Patel, Caroline Besley, Robert F Wynn, Ajay Vora, David I. Marks, Lindsay George, Ben Uttenthal, Sridhar Chaganti, Michelle Cummins, Persis J Amrolia, Rachael E Hough, Sara Ghorashian
Publikováno v:
Blood. 140:2408-2410
Autor:
Sara Ghorashian, Giovanna Lucchini, Rachel Richardson, Kyvi Nguyen, Craig Terris, Macarena Oporto-Espuelas, Jenny Yeung, Danielle Pinner, Jan Chu, Lindsey Williams, Ka-yuk Ko, Chloe Walding, Kelly Watts, Sarah Inglott, Stuart Adams, Emma Gravett, Kimberly Gilmour, Alka Lal, Sangeetha Kunaseelan, Bilyana Popova, Andre Lopes, Yenting Ngai, Evangelia K Kokalaki, Milena Balasch Carulla, Khushnuma Mullanfiroze, Arina Lazareva, Vesna Pavasovic, Anupama Rao, Jack Bartram, Ajay Vora, Robert Chiesa, Juliana Silva, Kanchan Rao, Katherine Clesham, Denise Bonney, Robert F Wynn, Martin Pule, Rachael E Hough, Persis J Amrolia
Publikováno v:
Blood. 140:10352-10354
Autor:
Ilaria M. Michelozzi, Eduardo Gomez-Castaneda, Ruben V. C. Pohle, Ferran Cardoso Rodriguez, Jahangir Sufi, Pau Puigdevall Costa, Meera Subramaniyam, Efstratios Kirtsios, Ayad Eddaoudi, Si Wei Wu, Aleks Guvenel, Jonathan Fisher, Sara Ghorashian, Martin A. Pule, Christopher J. Tape, Sergi Castellano, Persis J. Amrolia, Alice Giustacchini
Publikováno v:
Blood advances.
We recently described a low-affinity second-generation CD19 chimeric antigen receptor (CAR) CAT that showed enhanced expansion, cytotoxicity, and antitumor efficacy compared with the high-affinity (FMC63-based) CAR used in tisagenlecleucel, in precli
Autor:
Nushmia Z. Khokhar, Denise Bonney, Paul Virgo, Saket Srivastava, Simon Thomas, Ram Jha, Jan Chu, Shaun Cordoba, Robert Chiesa, Persis Amrolia, Yiyun Zhang, Jeremy Hancock, Rachael Hough, Carlotta Peticone, Shimobi Onuoha, Kanchan Rao, Vania Baldan, Kevin Duffy, Paul Veys, Lucy Wheeler, Robert Wynn, William Day, Daniela Soriano Pignataro, Sara Ghorashian, Giovanna Lucchini, Koval Smith, Martin Pule, Liz Clark, Vijay G R Peddareddigari, Mathieu Ferrari, Sabine Domning, Ajay Vora, Frederick Arce Vargas, Muhammad Al-Hajj, Mei Mei Fung, Farzin Farzaneh
Publikováno v:
Nature Medicine
Chimeric antigen receptor (CAR) T cells targeting CD19 or CD22 have shown remarkable activity in B cell acute lymphoblastic leukemia (B-ALL). The major cause of treatment failure is antigen downregulation or loss. Dual antigen targeting could potenti