Obstructive and restrictive spirometry from school age to adulthood: three birth cohort studiesResearch in context

Autor: Anhar Ullah, Raquel Granell, Sadia Haider, Lesley Lowe, Sara Fontanella, Hasan Arshad, Clare S. Murray, Steve Turner, John W. Holloway, Angela Simpson, Graham Roberts, Adnan Custovic, John Ainsworth, Philip Couch, Paul Cullinan, Graham Devereux, Ashley Woodcock

Publikováno v: EClinicalMedicine, Vol 67, Iss , Pp 102355- (2024)

Summary: Background: Spirometric obstruction and restriction are two patterns of impaired lung function which are predictive of poor health. We investigated the development of these phenotypes and their transitions through childhood to early adulthoo

Externí odkaz: https://doaj.org/article/c137ec551656448bad2bd83ddcdf85cc

Sex differences in innate anti-viral immune responses to respiratory viruses and in their clinical outcomes in a birth cohort study

Autor: Eteri Regis, Sara Fontanella, Lijing Lin, Rebecca Howard, Sadia Haider, John A. Curtin, Michael R. Edwards, Magnus Rattray, Angela Simpson, Adnan Custovic, Sebastian L. Johnston

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

Abstract The mechanisms explaining excess morbidity and mortality in respiratory infections among males are poorly understood. Innate immune responses are critical in protection against respiratory virus infections. We hypothesised that innate immune

Externí odkaz: https://doaj.org/article/e667c858cf0341aaa467bae5485baa98

Dog ownership in infancy is protective for persistent wheeze in 17q21 asthma-risk carriers

Autor: Mauro Tutino, Raquel Granell, John A. Curtin, Sadia Haider, Sara Fontanella, Clare S. Murray, Graham Roberts, S. Hasan Arshad, Stephen Turner, Andrew P. Morris, Adnan Custovic, Angela Simpson

Publikováno v: STELAR/UNICORN investigators 2023, ' Dog ownership in infancy is protective for persistent wheeze in 17q21 asthma-risk carriers ', The Journal of allergy and clinical immunology, vol. 151, no. 2, pp. 423-430 . https://doi.org/10.1016/j.jaci.2022.10.012
Tutino, M, Granell, R, Curtin, J A, Haider, S, Fontanella, S, Murray, C S, Roberts, G, Arshad, S H, Turner, S, Morris, A P & Custovic, A & Simpson, A 2022, ' Dog ownership in infancy is protective for persistent wheeze in 17q21 asthma-risk carriers ', Journal of Allergy and Clinical Immunology . https://doi.org/10.1016/j.jaci.2022.10.012
STELAR/UNICORN investigators 2022, ' Dog ownership in infancy is protective for persistent wheeze in 17q21 asthma-risk carriers ', Journal of Allergy and Clinical Immunology . https://doi.org/10.1016/j.jaci.2022.10.012

BackgroundAsthma-associated single nucleotide polymorphisms from large genome-wide association studies only explain a fraction of genetic heritability. Likely causes of the missing heritability include broad phenotype definitions and gene-environment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c092f09e1529356920bc8a80fea871b5
https://doi.org/10.1016/j.jaci.2022.10.012

Reply to Beck et al. and to Owora

Autor: Adnan Custovic, Sara Fontanella, Sadia Haider

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 207:634-636

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fccc9f90d0d56ea8715fef1ab645b0cd
https://doi.org/10.1164/rccm.202211-2130le

Current state and prospects of artificial intelligence in allergy

Autor: Merlijn van Breugel, Rudolf S. N. Fehrmann, Marnix Bügel, Faisal I. Rezwan, John Holloway, Martijn Nawijn, Sara Fontanella, A Custovic, Gerard Koppelman

The field of medicine is witnessing an exponential growth of interest in Artificial Intelligence (AI), which enables new research questions and the analysis of larger and new types of data. Nevertheless, applications that go beyond proof of concepts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf929331a60b4d6c1d11c787d2d6704c
https://doi.org/10.22541/au.168205335.50148000/v1