Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Sara, De Martin"'
Autor:
Martina Colognesi, Atea Shkodra, Daniela Gabbia, Hibiki Kawamata, Paolo L. Manfredi, Giovanni Manfredi, Sara De Martin
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
IntroductionThe pathogenesis of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease caused by the demise of motor neurons has been linked to excitotoxicity caused by excessive calcium influx via N-methyl-D-aspartate receptors (NMDA
Externí odkaz:
https://doaj.org/article/a9c08acc41ac419d863b77ac7c3071c8
Autor:
Nicola Ferri, Sara De Martin, James Stuart, Sergio Traversa, Franco Folli, Marco Pappagallo, Cedric O’Gorman, Clotilde Guidetti, Andrea Mattarei, Charles E. Inturrisi, Paolo L. Manfredi
Publikováno v:
Drugs in R&D, Vol 24, Iss 1, Pp 51-68 (2023)
Abstract Background and Objective Esmethadone (dextromethadone; d-methadone; S-methadone (+)-methadone; REL-1017) is the opioid inactive dextro-isomer of racemic methadone. Esmethadone is a low potency N-methyl-D-aspartate (NMDA) receptor channel blo
Externí odkaz:
https://doaj.org/article/9a07ec79820f4842b2bf83183c3444df
Autor:
Daniela Gabbia, Sara De Martin
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4188 (2024)
Hepatocellular carcinoma (HCC), the most common primary liver cancer, accounts for 830,180 related deaths worldwide in 2020, according to GLOBOCAN, representing the fourth leading cause of cancer-related death, with a five-year survival rate of about
Externí odkaz:
https://doaj.org/article/b99ae5a6ef1f44cda783557f87702454
Publikováno v:
Life, Vol 14, Iss 4, p 500 (2024)
Gender Medicine has had an enormous expansion over the last ten years. Autoimmune liver diseases include several conditions, i.e., autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and conditions inv
Externí odkaz:
https://doaj.org/article/3fcdc12223e849a4bda36ad7c312bb99
Autor:
Megan J. Shram, Jack E. Henningfield, Glen Apseloff, Charles W. Gorodetzky, Sara De Martin, Frank L. Vocci, Frank L. Sapienza, Thomas R. Kosten, Jeff Huston, August Buchhalter, Judy Ashworth, Ryan Lanier, Franco Folli, Andrea Mattarei, Clotilde Guidetti, Stefano Comai, Cedric O’Gorman, Sergio Traversa, Charles E. Inturrisi, Paolo L. Manfredi, Marco Pappagallo
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Esmethadone (REL-1017) is the opioid-inactive dextro-isomer of methadone and a low-affinity, low-potency uncompetitive NMDA receptor antagonist. In a Phase 2, randomized, double-blind, placebo-controlled trial, esmethadone showed rapid, robu
Externí odkaz:
https://doaj.org/article/b958bfa2946e4409a7e15362350d0462
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2194 (2024)
Primary biliary cholangitis (PBC) is an autoimmune liver disease characterised by the immune-mediated destruction of small and medium intrahepatic bile ducts, with variable outcomes and progression. This review summarises the state of the art regardi
Externí odkaz:
https://doaj.org/article/5d8105cc229a4e5fb77d444d558bee31
Autor:
Daniela Gabbia, Sara De Martin
Publikováno v:
Biology, Vol 12, Iss 12, p 1471 (2023)
The gut microbiota is a complex system, playing a peculiar role in regulating innate and systemic immunity. Increasing evidence links dysfunctional gut microbiota to metabolic dysfunction-associated steatotic liver disease (MASLD) due to the activati
Externí odkaz:
https://doaj.org/article/25415e7b09c44f59b27c93283c6cbaff
Autor:
Katia Sayaf, Ilaria Zanotto, Daniela Gabbia, Dafne Alberti, Giulia Pasqual, Alice Zaramella, Alberto Fantin, Sara De Martin, Francesco Paolo Russo
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16452 (2023)
Liver fibrosis is a common and reversible feature of liver damage associated with many chronic liver diseases, and its onset is influenced by sex. In this study, we investigated the mechanisms of liver fibrosis and regeneration, focusing on understan
Externí odkaz:
https://doaj.org/article/2a0ea45402fb4944874b827877843bb1
Autor:
Daniela Gabbia, Sara Carpi, Samantha Sarcognato, Ilaria Zanotto, Katia Sayaf, Martina Colognesi, Beatrice Polini, Maria Digiacomo, Marco Macchia, Paola Nieri, Maria Carrara, Nora Cazzagon, Francesco Paolo Russo, Maria Guido, Sara De Martin
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 157, Iss , Pp 114014- (2023)
Liver fibrosis is the result of a chronic pathological condition caused by the activation of hepatic stellate cells (HSCs), which induces the excessive deposition of extracellular matrix. Fibrogenesis is sustained by an exaggerated production of reac
Externí odkaz:
https://doaj.org/article/4a24bdd493fa4d008b242f3c996f010c
Autor:
Daniela Gabbia, Sara De Martin
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 9018 (2023)
Liver cancer remains a global health challenge and its incidence is growing worldwide [...]
Externí odkaz:
https://doaj.org/article/c7e048c69b48486d81181ac86b04df97