Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Saptaparna Mukherjee"'
Autor:
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 6, Pp 719-740 (2024)
Abstract Tumor suppressor p53 (TP53) is frequently mutated in cancer, often resulting not only in loss of its tumor-suppressive function but also acquisition of dominant-negative and even oncogenic gain-of-function traits. While wild-type p53 levels
Externí odkaz:
https://doaj.org/article/4644b709c6d143dfb92c748768749b96
Autor:
Anat Gershoni, Ori Hassin, Nishanth Belugali Nataraj, Sivan Baruch, Adi Avioz‐Seligman, Anna Chiara Pirona, Liat Fellus‐Alyagor, Tomer Meir Salame, Saptaparna Mukherjee, Giuseppe Mallel, Yosef Yarden, Yael Aylon, Moshe Oren
Publikováno v:
Molecular Oncology, Vol 17, Iss 12, Pp 2675-2693 (2023)
The core Hippo pathway module consists of a tumour‐suppressive kinase cascade that inhibits the transcriptional coactivators Yes‐associated protein (YAP) and WW domain‐containing transcription regulator protein 1 (WWTR1; also known as TAZ). Whe
Externí odkaz:
https://doaj.org/article/2dbf7e08c0fc4450b4c84ececd4af0cb
Autor:
Yael Aylon, Noa Furth, Giuseppe Mallel, Gilgi Friedlander, Nishanth Belugali Nataraj, Meng Dong, Ori Hassin, Rawan Zoabi, Benjamin Cohen, Vanessa Drendel, Tomer Meir Salame, Saptaparna Mukherjee, Nofar Harpaz, Randy Johnson, Walter E. Aulitzky, Yosef Yarden, Efrat Shema, Moshe Oren
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
LATS1 is reported to regulate the transition of luminal-basal-like cell plasticity in breast cancer. Here the authors report that LATS1 limits the progression of luminal breast cancer by associating with NCOR1 nuclear corepressor to repress ERα-down
Externí odkaz:
https://doaj.org/article/4ccbb8ac8c2f4c92a83690814f9d6056
Autor:
Ori Hassin, Nishanth Belugali Nataraj, Michal Shreberk-Shaked, Yael Aylon, Rona Yaeger, Giulia Fontemaggi, Saptaparna Mukherjee, Martino Maddalena, Adi Avioz, Ortal Iancu, Giuseppe Mallel, Anat Gershoni, Inna Grosheva, Ester Feldmesser, Shifra Ben-Dor, Ofra Golani, Ayal Hendel, Giovanni Blandino, David Kelsen, Yosef Yarden, Moshe Oren
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The differential effects of TP53 missense mutations in colorectal cancer (CRC) remain to be explored. Here the authors compare the gain of function impact of two frequent TP53 mutations in CRC and show that p53R273 mutants control a transcriptional p
Externí odkaz:
https://doaj.org/article/a119b82dad0a479ebb369694272fe374
Autor:
Yael Aylon, Noa Furth, Giuseppe Mallel, Gilgi Friedlander, Nishanth Belugali Nataraj, Meng Dong, Ori Hassin, Rawan Zoabi, Benjamin Cohen, Vanessa Drendel, Tomer Meir Salame, Saptaparna Mukherjee, Nofar Harpaz, Randy Johnson, Walter E. Aulitzky, Yosef Yarden, Efrat Shema, Moshe Oren
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/d860069f12304f2f8bdcacb82805f013
Autor:
Gal Benor, Garold Fuks, Suet‐Feung Chin, Oscar M. Rueda, Saptaparna Mukherjee, Sharathchandra Arandkar, Yael Aylon, Carlos Caldas, Eytan Domany, Moshe Oren
Publikováno v:
Molecular Oncology, Vol 14, Iss 8, Pp 1640-1652 (2020)
TP53 gene mutations are very common in human cancer. While such mutations abrogate the tumor suppressive activities of the wild‐type (wt) p53 protein, some of them also endow the mutant (mut) protein with oncogenic gain of function (GOF), facilitat
Externí odkaz:
https://doaj.org/article/0e3731e53bbb46d18432564f83817490
Autor:
Yosef Yarden, Eytan Ruppin, Gad Getz, Aviv Regev, Joan S. Brugge, Rami I. Aqeilan, Trever G. Bivona, Laxmi Parida, Stefan Wiemann, Jideofor Ezike, Collin M. Blakely, Moshe Oren, Andrea Ardizzoni, Michelangelo Fiorentino, Mattia Lauriola, Brian P. Danysh, Diana Drago-Garcia, Youngmin Chung, Suvendu Giri, Arunachalam Sekar, Wei Wu, D. Lucas Kerr, Alexander Brandis, Sanju Sinha, Welles Robinson, Simone Borgoni, Rishita Chatterjee, Aakanksha Verma, Arturo Simoni-Nieves, Soma Ghosh, Rainer Will, Saptaparna Mukherjee, Moshit Lindzen, Sara Oster, Yaara Oren, Benny Zhitomirsky, Joo Sang Lee, Nishanth Belugali Nataraj, Ashish Noronha
Anticancer therapies have been limited by the emergence of mutations and other adaptations. In bacteria, antibiotics activate the SOS response, which mobilizes error-prone factors that allow for continuous replication at the cost of mutagenesis. We i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90156dccca93cef0832f1138ce45eef
https://doi.org/10.1158/2159-8290.c.6549711
https://doi.org/10.1158/2159-8290.c.6549711
Autor:
Yosef Yarden, Eytan Ruppin, Gad Getz, Aviv Regev, Joan S. Brugge, Rami I. Aqeilan, Trever G. Bivona, Laxmi Parida, Stefan Wiemann, Jideofor Ezike, Collin M. Blakely, Moshe Oren, Andrea Ardizzoni, Michelangelo Fiorentino, Mattia Lauriola, Brian P. Danysh, Diana Drago-Garcia, Youngmin Chung, Suvendu Giri, Arunachalam Sekar, Wei Wu, D. Lucas Kerr, Alexander Brandis, Sanju Sinha, Welles Robinson, Simone Borgoni, Rishita Chatterjee, Aakanksha Verma, Arturo Simoni-Nieves, Soma Ghosh, Rainer Will, Saptaparna Mukherjee, Moshit Lindzen, Sara Oster, Yaara Oren, Benny Zhitomirsky, Joo Sang Lee, Nishanth Belugali Nataraj, Ashish Noronha
Supplementary Figure from AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b3d798497aa0ca157a505f562f91a6
https://doi.org/10.1158/2159-8290.22541643.v1
https://doi.org/10.1158/2159-8290.22541643.v1
Autor:
Yosef Yarden, Eytan Ruppin, Gad Getz, Aviv Regev, Joan S. Brugge, Rami I. Aqeilan, Trever G. Bivona, Laxmi Parida, Stefan Wiemann, Jideofor Ezike, Collin M. Blakely, Moshe Oren, Andrea Ardizzoni, Michelangelo Fiorentino, Mattia Lauriola, Brian P. Danysh, Diana Drago-Garcia, Youngmin Chung, Suvendu Giri, Arunachalam Sekar, Wei Wu, D. Lucas Kerr, Alexander Brandis, Sanju Sinha, Welles Robinson, Simone Borgoni, Rishita Chatterjee, Aakanksha Verma, Arturo Simoni-Nieves, Soma Ghosh, Rainer Will, Saptaparna Mukherjee, Moshit Lindzen, Sara Oster, Yaara Oren, Benny Zhitomirsky, Joo Sang Lee, Nishanth Belugali Nataraj, Ashish Noronha
Supplementary Data from AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e7bdbe0faeb9783a3dfad67e1dd091
https://doi.org/10.1158/2159-8290.22541646.v1
https://doi.org/10.1158/2159-8290.22541646.v1
Autor:
Moshe Oren, Eytan Ruppin, Giovanni Blandino, Yael Aylon, Saptaparna Mukherjee, Ido Azuri, Silvia Di Agostino, Sanju Sinha, Bareket Dassa, Michal Shreberk-Shaked
Lung cancer is the leading cause of cancer-related deaths worldwide. The paralogous transcriptional cofactors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ, also called WWTR1), the main downstream effectors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7ba38facb92c775aa224d94c378c62
https://doi.org/10.1158/0008-5472.c.6512052
https://doi.org/10.1158/0008-5472.c.6512052