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A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation.

Autor: Padmanabhan A; Gladstone Institutes, San Francisco, CA, USA. arun.padmanabhan@gladstone.ucsf.edu.; Department of Medicine, University of California, San Francisco, School of Medicine, San Francisco, CA, USA. arun.padmanabhan@gladstone.ucsf.edu.; Chan Zuckerberg Biohub, San Francisco, CA, USA. arun.padmanabhan@gladstone.ucsf.edu., de Soysa TY; Gladstone Institutes, San Francisco, CA, USA., Pelonero A; Gladstone Institutes, San Francisco, CA, USA., Sapp V; Department of Medicine, University of California, San Diego, School of Medicine, San Diego, CA, USA.; Department of Pharmacology, University of California, San Diego, San Diego, CA, USA., Shah PP; Cardiovascular Institute, Epigenetics Institute, and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA., Wang Q; Cardiovascular Institute, Epigenetics Institute, and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA., Li L; Cardiovascular Institute, Epigenetics Institute, and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA., Lee CY; Gladstone Institutes, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, School of Medicine, San Francisco, CA, USA., Sadagopan N; Gladstone Institutes, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, School of Medicine, San Francisco, CA, USA., Nishino T; Gladstone Institutes, San Francisco, CA, USA., Ye L; Gladstone Institutes, San Francisco, CA, USA., Yang R; Cardiovascular Institute, Epigenetics Institute, and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA., Karnay A; Cardiovascular Institute, Epigenetics Institute, and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA., Poleshko A; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA., Bolar N; Cardiovascular Institute, Epigenetics Institute, and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA., Linares-Saldana R; Cardiovascular Institute, Epigenetics Institute, and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA., Ranade SS; Gladstone Institutes, San Francisco, CA, USA., Alexanian M; Gladstone Institutes, San Francisco, CA, USA.; Department of Pediatrics, University of California, San Francisco, School of Medicine, San Francisco, CA, USA., Morton SU; Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Jain M; Department of Medicine, University of California, San Diego, School of Medicine, San Diego, CA, USA.; Department of Pharmacology, University of California, San Diego, San Diego, CA, USA., Haldar SM; Gladstone Institutes, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, School of Medicine, San Francisco, CA, USA.; Amgen Research, Cardiometabolic Disorders, South San Francisco, CA, USA., Srivastava D; Gladstone Institutes, San Francisco, CA, USA. deepak.srivastava@gladstone.ucsf.edu.; Department of Pediatrics, University of California, San Francisco, School of Medicine, San Francisco, CA, USA. deepak.srivastava@gladstone.ucsf.edu.; Roddenberry Center for Stem Cell Biology and Medicine at Gladstone Institutes, San Francisco, CA, USA. deepak.srivastava@gladstone.ucsf.edu.; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA. deepak.srivastava@gladstone.ucsf.edu., Jain R; Cardiovascular Institute, Epigenetics Institute, and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. jainr@pennmedicine.upenn.edu.; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA. jainr@pennmedicine.upenn.edu.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2024 Mar; Vol. 3 (3), pp. 317-331. Date of Electronic Publication: 2024 Feb 23.