Complex Metabolism of the Novel Neurosteroid, Ganaxolone, in Humans: A Unique Challenge for Metabolites in Safety Testing Assessment.

Autor: Fitch WL; Marinus Pharmaceuticals Inc., Radnor, Pennsylvania (M.S., S.S.); Labcorp Drug Development, Madison, Wisconsin (M.E.F., P.Y.); Quintara Discovery Inc., Hayward, California (J.R.); Division of Gastroenterology and Hepatology, Stanford School of Medicine, Stanford, California (W.L.F.); Novatia LLC, Newtown, Pennsylvania (A.C.); Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington (T.A.B.); 3R Services, LLC, North Haven, Connecticut (M.Z.); and Pharmaron ABS, Germantown, Maryland (S.E.)., Smith S; Marinus Pharmaceuticals Inc., Radnor, Pennsylvania (M.S., S.S.); Labcorp Drug Development, Madison, Wisconsin (M.E.F., P.Y.); Quintara Discovery Inc., Hayward, California (J.R.); Division of Gastroenterology and Hepatology, Stanford School of Medicine, Stanford, California (W.L.F.); Novatia LLC, Newtown, Pennsylvania (A.C.); Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington (T.A.B.); 3R Services, LLC, North Haven, Connecticut (M.Z.); and Pharmaron ABS, Germantown, Maryland (S.E.)., Saporito M; Marinus Pharmaceuticals Inc., Radnor, Pennsylvania (M.S., S.S.); Labcorp Drug Development, Madison, Wisconsin (M.E.F., P.Y.); Quintara Discovery Inc., Hayward, California (J.R.); Division of Gastroenterology and Hepatology, Stanford School of Medicine, Stanford, California (W.L.F.); Novatia LLC, Newtown, Pennsylvania (A.C.); Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington (T.A.B.); 3R Services, LLC, North Haven, Connecticut (M.Z.); and Pharmaron ABS, Germantown, Maryland (S.E.)., Busse G; Marinus Pharmaceuticals Inc., Radnor, Pennsylvania (M.S., S.S.); Labcorp Drug Development, Madison, Wisconsin (M.E.F., P.Y.); Quintara Discovery Inc., Hayward, California (J.R.); Division of Gastroenterology and Hepatology, Stanford School of Medicine, Stanford, California (W.L.F.); Novatia LLC, Newtown, Pennsylvania (A.C.); Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington (T.A.B.); 3R Services, LLC, North Haven, Connecticut (M.Z.); and Pharmaron ABS, Germantown, Maryland (S.E.)., Zhang M; Marinus Pharmaceuticals Inc., Radnor, Pennsylvania (M.S., S.S.); Labcorp Drug Development, Madison, Wisconsin (M.E.F., P.Y.); Quintara Discovery Inc., Hayward, California (J.R.); Division of Gastroenterology and Hepatology, Stanford School of Medicine, Stanford, California (W.L.F.); Novatia LLC, Newtown, Pennsylvania (A.C.); Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington (T.A.B.); 3R Services, LLC, North Haven, Connecticut (M.Z.); and Pharmaron ABS, Germantown, Maryland (S.E.)., Ren J; Marinus Pharmaceuticals Inc., Radnor, Pennsylvania (M.S., S.S.); Labcorp Drug Development, Madison, Wisconsin (M.E.F., P.Y.); Quintara Discovery Inc., Hayward, California (J.R.); Division of Gastroenterology and Hepatology, Stanford School of Medicine, Stanford, California (W.L.F.); Novatia LLC, Newtown, Pennsylvania (A.C.); Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington (T.A.B.); 3R Services, LLC, North Haven, Connecticut (M.Z.); and Pharmaron ABS, Germantown, Maryland (S.E.)., Fitzsimmons ME; Marinus Pharmaceuticals Inc., Radnor, Pennsylvania (M.S., S.S.); Labcorp Drug Development, Madison, Wisconsin (M.E.F., P.Y.); Quintara Discovery Inc., Hayward, California (J.R.); Division of Gastroenterology and Hepatology, Stanford School of Medicine, Stanford, California (W.L.F.); Novatia LLC, Newtown, Pennsylvania (A.C.); Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington (T.A.B.); 3R Services, LLC, North Haven, Connecticut (M.Z.); and Pharmaron ABS, Germantown, Maryland (S.E.)., Yi P; Marinus Pharmaceuticals Inc., Radnor, Pennsylvania (M.S., S.S.); Labcorp Drug Development, Madison, Wisconsin (M.E.F., P.Y.); Quintara Discovery Inc., Hayward, California (J.R.); Division of Gastroenterology and Hepatology, Stanford School of Medicine, Stanford, California (W.L.F.); Novatia LLC, Newtown, Pennsylvania (A.C.); Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington (T.A.B.); 3R Services, LLC, North Haven, Connecticut (M.Z.); and Pharmaron ABS, Germantown, Maryland (S.E.)., English S; Marinus Pharmaceuticals Inc., Radnor, Pennsylvania (M.S., S.S.); Labcorp Drug Development, Madison, Wisconsin (M.E.F., P.Y.); Quintara Discovery Inc., Hayward, California (J.R.); Division of Gastroenterology and Hepatology, Stanford School of Medicine, Stanford, California (W.L.F.); Novatia LLC, Newtown, Pennsylvania (A.C.); Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington (T.A.B.); 3R Services, LLC, North Haven, Connecticut (M.Z.); and Pharmaron ABS, Germantown, Maryland (S.E.)., Carter A; Marinus Pharmaceuticals Inc., Radnor, Pennsylvania (M.S., S.S.); Labcorp Drug Development, Madison, Wisconsin (M.E.F., P.Y.); Quintara Discovery Inc., Hayward, California (J.R.); Division of Gastroenterology and Hepatology, Stanford School of Medicine, Stanford, California (W.L.F.); Novatia LLC, Newtown, Pennsylvania (A.C.); Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington (T.A.B.); 3R Services, LLC, North Haven, Connecticut (M.Z.); and Pharmaron ABS, Germantown, Maryland (S.E.)., Baillie TA; Marinus Pharmaceuticals Inc., Radnor, Pennsylvania (M.S., S.S.); Labcorp Drug Development, Madison, Wisconsin (M.E.F., P.Y.); Quintara Discovery Inc., Hayward, California (J.R.); Division of Gastroenterology and Hepatology, Stanford School of Medicine, Stanford, California (W.L.F.); Novatia LLC, Newtown, Pennsylvania (A.C.); Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington (T.A.B.); 3R Services, LLC, North Haven, Connecticut (M.Z.); and Pharmaron ABS, Germantown, Maryland (S.E.).

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2023 Jun; Vol. 51 (6), pp. 753-763. Date of Electronic Publication: 2023 Mar 02.

Functional characterization of a novel p.Ser76Thr variant in IGFBP4 that associates with body mass index in American Indians.

Autor: Muller YL; Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA. ymuller@mail.nih.gov., Saporito M; Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA., Day S; Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA., Bandesh K; Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA., Koroglu C; Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA., Kobes S; Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA., Knowler WC; Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA., Hanson RL; Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA., Van Hout CV; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.; Laboratorio Internacional de Investigation sobre el Genoma Humano, Campus Juriquilla de la Universidad Nacional Autonoma de Mexico, Queretaro, QRO, Mexico., Shuldiner AR; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Bogardus C; Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA., Baier LJ; Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA.

Publikováno v: European journal of human genetics : EJHG [Eur J Hum Genet] 2022 Oct; Vol. 30 (10), pp. 1159-1166. Date of Electronic Publication: 2022 Jun 10.

Snapping Triceps

Autor: Ciaramella, G., Saporito, M., Fauci, F., Porcellini, G.

Publikováno v: The Elbow ISBN: 9783319278032

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::656781a6f0c89b977ad7abae0749b4fa
https://doi.org/10.1007/978-3-319-27805-6_29

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Smart horticulture as an emerging interdisciplinary field combining novel solutions: Past development, current challenges, and future perspectives.

Autor: Moran Zhang^1,2,3, Yutong Han¹, Dongping Li⁴, Shengyong Xu^1,2,5 xsy@mail.hzau.edu.cn, Yuan Huang^2,5,6 huangyuan@mail.hzau.edu.cn

Publikováno v: Horticulture Plant Journal. Nov2024, Vol. 10 Issue 6, p1257-1273. 17p.