Zobrazeno 1 - 10
of 2 108
pro vyhledávání: '"Saporin"'
Autor:
Stefania Zuppone, Natasa Zarovni, Kosuke Noguchi, Francesca Loria, Carlo Morasso, Andres Lõhmus, Ikuhiko Nakase, Riccardo Vago
Publikováno v:
Discover Nano, Vol 19, Iss 1, Pp 1-15 (2024)
Abstract Extracellular vesicles (EVs) have mostly been investigated as carriers of biological therapeutics such as proteins and RNA. Nevertheless, small-molecule drugs of natural or synthetic origin have also been loaded into EVs, resulting in an imp
Externí odkaz:
https://doaj.org/article/bfeb047ecafd45ee9219f6d3b5d26b36
Autor:
Maria Ciuro, Maria Sangiorgio, Valeria Cacciato, Giuliano Cantone, Carlo Fichera, Lucia Salvatorelli, Gaetano Magro, Giampiero Leanza, Michele Vecchio, Maria Stella Valle, Rosario Gulino
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7059 (2024)
Amyotrophic lateral sclerosis (ALS) is an extremely complex neurodegenerative disease involving different cell types, but motoneuronal loss represents its main pathological feature. Moreover, compensatory plastic changes taking place in parallel to n
Externí odkaz:
https://doaj.org/article/cd5d4da1f38f40098159b7e05f35d6ca
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Balázs Ujvári, Bence Pytel, Zsombor Márton, Máté Bognár, László Ákos Kovács, József Farkas, Tamás Gaszner, Gergely Berta, Angéla Kecskés, Viktória Kormos, Boglárka Farkas, Nóra Füredi, Balázs Gaszner
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-17 (2022)
Abstract Background The neuropathological background of major depression and anxiety as non-motor symptoms of Parkinson’s disease is much less understood than classical motor symptoms. Although, neurodegeneration of the Edinger–Westphal nucleus i
Externí odkaz:
https://doaj.org/article/749adc7e269846f8b223552ae1b54b24
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Yuko Maejima, Shoko Yokota, Masaru Shimizu, Shoichiro Horita, Daisuke Kobayashi, Akihiro Hazama, Kenju Shimomura
Publikováno v:
Nutrition & Metabolism, Vol 18, Iss 1, Pp 1-15 (2021)
Abstract Background Feeding rhythm disruption contributes to the development of obesity. The receptors of glucagon-like peptide-1 (GLP-1) are distributed in the wide regions of the brain. Among these regions, GLP-1 receptors (GLP-1R) are expressed in
Externí odkaz:
https://doaj.org/article/e2c9447372424a83bcc795d655f055d1
Autor:
Stefania Zuppone, Chiara Assalini, Claudia Minici, Oronza A. Botrugno, Flavio Curnis, Massimo Degano, Angelo Corti, Francesco Montorsi, Andrea Salonia, Riccardo Vago
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Although toxin may have some advantages compared to chemotherapeutic drugs in cancer therapy, e.g. a potent cytotoxic activity and a reduced risk of resistance, their successful application in the treatments to solid tumors still remains to be fully
Externí odkaz:
https://doaj.org/article/e32562cd4c1948f695e2baa6a239f800
Publikováno v:
Toxins, Vol 15, Iss 3, p 181 (2023)
Streptavidin-Saporin can be considered a type of ‘secondary’ targeted toxin. The scientific community has taken advantage of this conjugate in clever and fruitful ways using many kinds of biotinylated targeting agents to send saporin into a cell
Externí odkaz:
https://doaj.org/article/4f483359dbc54ac189a831b066f185ec
Autor:
Shihyoung Kim, Rajni Kant Shukla, Eunsoo Kim, Sophie G. Cressman, Hannah Yu, Alice Baek, Hyewon Choi, Alan Kim, Amit Sharma, Zhirui Wang, Christene A. Huang, John C. Reneau, Prosper N. Boyaka, Namal P. M. Liyanage, Sanggu Kim
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1221 (2022)
Anti-CD3-epsilon (CD3e) monoclonal antibodies (mAbs) and CD3e immunotoxins (ITs) are promising targeted therapy options for various T-cell disorders. Despite significant advances in mAb and IT engineering, vascular leakage syndrome (VLS) remains a ma
Externí odkaz:
https://doaj.org/article/af538e4d4c3c4a8294f7418f482deb4b