Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Sapna Pradyuman Patel"'
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Hypoxia is not only a prominent contributor to the heterogeneity of solid tumors but also a crucial stressor in the microenvironment to drive adaptations for tumors to evade immunosurveillance. Herein, we discuss the potential role of hypoxia within
Externí odkaz:
https://doaj.org/article/7487e28013fe4b9baede51dce85154b5
Autor:
Bert H. O'Neil, Johannes Wolff, Jessica E. Hutti, Anjla Sood, Dimple Modi, Kevin J. Freise, Beibei Hu, Xiaotian Chen, Primo N. Lara, Sapna Pradyuman Patel, Russell Szmulewitz, Patricia LoRusso, Minal Barve, Jasgit C. Sachdev, Sarina A. Piha-Paul
Purpose:Bromodomain and extraterminal (BET) proteins play important roles in transcriptional regulation relevant to cancer pathogenesis, and therapeutic targeting/inhibition of BET causes apoptosis of cancer cells in vitro. In this first-in-human stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ad99796b453cefae1437df52e4d7fe
https://doi.org/10.1158/1078-0432.c.6527916.v1
https://doi.org/10.1158/1078-0432.c.6527916.v1
Autor:
Bert H. O'Neil, Johannes Wolff, Jessica E. Hutti, Anjla Sood, Dimple Modi, Kevin J. Freise, Beibei Hu, Xiaotian Chen, Primo N. Lara, Sapna Pradyuman Patel, Russell Szmulewitz, Patricia LoRusso, Minal Barve, Jasgit C. Sachdev, Sarina A. Piha-Paul
Supplemental Methods, Figures S1-S5, Tables S1-S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a20bf7172296d37524715111050edbb
https://doi.org/10.1158/1078-0432.22471509
https://doi.org/10.1158/1078-0432.22471509
Autor:
Omar Pacha, Rodabe N. Amaria, Lauren E. Haydu, Kelly C. Nelson, Isabella C. Glitza Oliva, M. Wong, Shirley Q. Li, Auris Huen, Sahira Farooq, Macartney Welborn, Ronald P. Rapini, Michael A. Davies, Anisha B. Patel, Jennifer L. McQuade, Sapna Pradyuman Patel, Adi Diab, Susan Y. Chon, Hussein Abdul-Hassan Tawbi
Publikováno v:
Cancer. 128:975-983
Background In response to the increased use of combination checkpoint inhibitors (CPIs) and the resulting increased cutaneous adverse events (CAEs), this study reviewed patients with melanoma treated with combination CPIs to characterize CAE features
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4e5cdc8bbe01ce567beacaaa1a1676
https://doi.org/10.1002/cncr.34004
https://doi.org/10.1002/cncr.34004
Autor:
Sapna Pradyuman Patel, David S. Hong, Vivek Subbiah, Amanda Johnston, Siqing Fu, John S. Bomalaski, Sarina Anne Piha-Paul, Shuyang Yao, Ahmed Kaseb, Aung Naing, Nai Shi, Filip Janku, Apostolia Maria Tsimberidou, Shannon N. Westin, John Stewart
Publikováno v:
Br J Cancer
Background Arginine depletion interferes with pyrimidine metabolism and DNA damage-repair pathways, and pairing arginine deiminase pegylated with 20,000-molecular-weight polyethylene glycol (ADI-PEG20) with platinum enhances cytotoxicity in vitro and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d35421e6155a20aeb943eeead2c5143
https://doi.org/10.1038/s41416-020-01230-8
https://doi.org/10.1038/s41416-020-01230-8
Autor:
Patrick Hwu, Liberty Posada, Maura S. Glover, Dan S. Gombos, Meredith S. Pelster, Michael Shephard, Brett W. Carter, Stephen K. Gruschkus, Roland L. Bassett, Sapna Pradyuman Patel, Adi Diab, Rinata Simien
Publikováno v:
J Clin Oncol
PURPOSE Metastatic uveal melanoma has poor overall survival (OS) and no approved systemic therapy options. Studies of single-agent immunotherapy regimens have shown minimal benefit. There is the potential for improved responses with the use of combin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae96c2e94d00df42bc177be6dbed225
https://doi.org/10.1200/jco.20.00605
https://doi.org/10.1200/jco.20.00605
Autor:
Andrew E. Aplin, Anna Han, Kyleigh LiPira, Jane Mattei, Lauren Johnston, Richard D. Carvajal, Sapna Pradyuman Patel, Vivian Chua, Sara Selig
Publikováno v:
Clin Cancer Res
Uveal melanoma is a rare cancer in adults, but its treatment is one of the clinical unmet needs in the melanoma field. Metastatic disease develops in approximately 50% of patients and is associated with poor survival due to the lack of effective trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266b73f6eb16206dc27077c55136755c
https://doi.org/10.1158/1078-0432.ccr-20-2536
https://doi.org/10.1158/1078-0432.ccr-20-2536
Autor:
Jeffrey E. Gershenwald, Jennifer A. Wargo, Richard A. Scolyer, Isabella C. Glitza Oliva, Matteo S. Carlino, Hussein Abdul-Hassan Tawbi, Alexander J. Lazar, Anthony Lucci, Michael T. Tetzlaff, Sherise D. Ferguson, Serigne Lo, Rodabe N. Amaria, Lauren E. Haydu, Robyn P. M. Saw, John F. Thompson, Jeffrey E. Lee, Jonathan R. Stretch, Sapna Pradyuman Patel, Adi Diab, Patrick Hwu, Alexander M. Menzies, Michael A. Davies, Kerwin F. Shannon, Merrick I. Ross, Georgina V. Long, Andrew J. Spillane, Michael K.K. Wong, Janice N. Cormier, Jennifer L. McQuade
Publikováno v:
J Clin Oncol
PURPOSE Improved understanding of the incidence, risk factors, and timing of CNS metastasis is needed to inform surveillance strategies for patients with melanoma. PATIENTS AND METHODS Clinical data were extracted from the databases of 2 major melano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904c4fd0c7c8f5a78baaaf34279588a2
https://doi.org/10.1200/jco.19.01508
https://doi.org/10.1200/jco.19.01508
Autor:
Brian R. Gastman, Ahmad A. Tarhini, Robert M. Conry, Pauline Funchain, Karl D. Lewis, Antoni Ribas, Sapna Pradyuman Patel, Hongli Li, Kenneth F. Grossmann, Magdalena Kovacsovics-Bankowski, Teresa M. Petrella, Elizabeth I. Buchbinder, Nageatte Ibrahim, Ragini R. Kudchadkar, James Moon, Douglas B. Johnson, Thach-Giao Truong, Larissa A. Korde, Michael V. Knopp, Kari Kendra, Elad Sharon, Scot Ebbinghaus, Bartosz Chmielowski, Vernon K. Sondak, John M. Kirkwood, Zeynep Eroglu, Nikhil I. Khushalani, Justine V. Cohen, Megan Othus, Krishna S Gunturu, Sama Ahsan
Publikováno v:
Cancer discovery, vol 12, iss 3
Cancer Discov
Cancer Discov
We conducted a randomized phase III trial to evaluate whether adjuvant pembrolizumab for one year (647 patients) improved recurrence-free survival (RFS) or overall survival (OS) in comparison with high-dose IFNα-2b for one year or ipilimumab for up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be95c3ea01eedee0bb4c9a85fc5d89b2
https://escholarship.org/uc/item/8x51z8rb
https://escholarship.org/uc/item/8x51z8rb
Autor:
Rodabe N. Amaria, Asim Amin, Hussein Abdul-Hassan Tawbi, Jessica Michaud Davis, Kourtney Holbrook, Isabella C. Glitza, Michael A. Davies, Sapna Pradyuman Patel, Adi Diab, Jose Lutzky
Publikováno v:
Cancer
Background Sixty percent of patients with stage IV melanoma may develop brain metastases, which result in significantly increased morbidity and a poor overall prognosis. Phase 3 studies of melanoma usually exclude patients with untreated brain metast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d272b8fe781b617355a302ffec361e5
http://europepmc.org/articles/PMC7004095
http://europepmc.org/articles/PMC7004095