Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sapna Morayya"'
Publikováno v:
Gene. 550:110-116
Most bacteria are able to generate sufficient amounts of ATP from substrate level phosphorylation, thus rendering the respiratory oxidative phosphorylation non-critical. In mycobacteria, including Mycobacterium tuberculosis, ATP generation by oxidati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aba9a21a727b5f175d20bed05f3daa5
https://doi.org/10.1016/j.gene.2014.08.024
https://doi.org/10.1016/j.gene.2014.08.024
Publikováno v:
Acta parasitologica. 61(4)
The pace of anti-malarial drug discovery is often impeded due to the lack of tools to determine the cidality of compounds in vitro. An anti-malarial compound must have a cidal mode of action, i.e. kill parasites, in order to quickly reduce parasite l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7360835fb8fac9b673f9564314d90450
https://pubmed.ncbi.nlm.nih.gov/27787213
https://pubmed.ncbi.nlm.nih.gov/27787213
Autor:
Shridhar Narayanan, Laura M. Sanz, Sreenivasaiah Menasinakai, Kevin Hickling, Abhishek Srivastava, Sapna Morayya, Anandkumar Raichurkar, Vikas Patil, Stefan Kavanagh, María Belén Jiménez-Díaz, Ramanatha Saralaya, Vijender Panduga, Gajanan Shanbag, Eknath V. Bellale, Lyn Rosenbrier-Ribeiro, K.R. Prabhakar, Anisha Ambady, David Waterson, Nikhil Rautela, Kannan Murugan, Pavithra Viswanath, Peter Warner, Pamela Magistrado, Pravin Iyer, Dyann F. Wirth, Jayashree Puttur, Krishna Koushik, Sowmya Bharath, Nilanjana Roy Choudhury, Philipp P. Henrich, Olivia Coburn-Flynn, Suresh Solapure, Radha Nandishaiah, Balachandra Bandodkar, Kakoli Mukherjee, María Santos Martínez, Suresh Rudrapatna, David A. Fidock, Shahul Hameed P, Vinayak Hosagrahara, Monalisa Chatterji, Vasan K. Sambandamurthy, V. Balasubramanian, Sudhir Landge, Jitendar Reddy, Robert E. McLaughlin, Amanda K. Lukens, Adam Jeston Dudley, Disha Awasthy
Publikováno v:
Nature Communications
The widespread emergence of Plasmodium falciparum (Pf) strains resistant to frontline agents has fuelled the search for fast-acting agents with novel mechanism of action. Here, we report the discovery and optimization of novel antimalarial compounds,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039caecc0852bb3bd72abf0265b59ccf
https://doi.org/10.1038/ncomms7715
https://doi.org/10.1038/ncomms7715
Autor:
K.R. Prabhakar, Iñigo Angulo-Barturen, Sandra Duffy, Ramachandran Sreekanth A, Shridhar Narayanan, Francisco-Javier Gamo, Laura M. Sanz, Santiago Ferrer, Anandkumar Raichurkar, María Belén Jiménez-Díaz, Vijender Panduga, Sreenivasaiah Menasinakai, Gajanan Shanbhag, Robert Nanduri, Marcus C. S. Lee, Nikhil Rautela, Sapna Morayya, Vinayak Hosagrahara, Disha Awasthy, Olivia Coburn-Flynn, María Santos Martínez, Sowmya Bharath, Jitendar Reddy, Vicky M. Avery, David Waterson, Abhishek Srivastava, Vasan K. Sambandamurthy, Ramanatha Saralaya, Vijayashree Achar, Pravin Iyer, Stefan Kavanagh, David A. Fidock, Shahul Hameed P
Publikováno v:
Journal of medicinal chemistry. 57(15)
From the phenotypic screening of the AstraZeneca corporate compound collection, N-aryl-2-aminobenzimidazoles have emerged as novel hits against the asexual blood stage of Plasmodium falciparum (Pf). Medicinal chemistry optimization of the potency aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb95443ee2483a372528128662dc1a76
https://pubmed.ncbi.nlm.nih.gov/25007124
https://pubmed.ncbi.nlm.nih.gov/25007124
Autor:
Eknath Bellale, Maruti Naik, Varun VB, Anisha Ambady, Ashwini Narayan, Sudha Ravishankar, Vasanthi Ramachandran, Parvinder Kaur, Robert McLaughlin, James Whiteaker, Sapna Morayya, Supreeth Guptha, Sreevalli Sharma, Anandkumar Raichurkar, Disha Awasthy, Vijayshree Achar, Prakash Vachaspati, Balachandra Bandodkar, Manoranjan Panda, Monalisa Chatterji
Publikováno v:
Journal of medicinal chemistry. 57(15)
Diarylthiazole (DAT), a hit from diversity screening, was found to have potent antimycobacterial activity against Mycobacterium tuberculosis (Mtb). In a systematic medicinal chemistry exploration, we demonstrated chemical opportunities to optimize th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1293e4207ed6ffc8afc4b8f8153dde09
https://pubmed.ncbi.nlm.nih.gov/24967731
https://pubmed.ncbi.nlm.nih.gov/24967731
Autor:
David Waterson, Stefan Kavanagh, V. Balasubramanian, Vijender Panduga, Francisco-Javier Gamo, María Santos Martínez, Shahul Hameed P, Vinayak Hosagrahara, María Belén Jiménez-Díaz, Shubhada Barde, Kakoli Mukherjee, Sandra Duffy, Santiago Ferrer, Vikas Patil, Balachandra Bandodkar, Ramachandran Sreekanth A, K.R. Prabhakar, Suresh Rudrapatna, Praveena Manjrekar, Iñigo Angulo-Barturen, Pravin Iyer, Vasan K. Sambandamurthy, Nikhil Rautela, Pamela Magistrado, Dyann F. Wirth, Sowmya Bharath, Chandan Narayan, Sapna Morayya, Murugan Chinnapattu, Pavithra Viswanath, Anandkumar Raichurkar, Krishna Koushik, Jitender Reddy, Vicky M. Avery, Achyut Sinha, Amanda K. Lukens, Disha Awasthy, Shridhar Narayanan, Laura M. Sanz, Gajanan Shanbag, Sandesh Jatheendranath, Abhishek Srivastava, Ramanatha Saralaya
Publikováno v:
Journal of medicinal chemistry. 57(13)
Whole-cell high-throughput screening of the AstraZeneca compound library against the asexual blood stage of Plasmodium falciparum (Pf) led to the identification of amino imidazoles, a robust starting point for initiating a hit-to-lead medicinal chemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf4f0771ba5683b3696782fe367bcc4a
https://pubmed.ncbi.nlm.nih.gov/24914738
https://pubmed.ncbi.nlm.nih.gov/24914738