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Akademický článek

Amyloid deposition and small vessel disease are associated with cognitive function in older adults with type 2 diabetes

Autor: Orit H. Lesman-Segev, Sapir Golan Shekhtman, Ramit Ravona Springer, Abigail Livny, Hung-Mo Lin, Ouyang Yuxia, Maya Zadok, Ithamar Ganmore, Anthony Heymann, Chen Hoffmann, Liran Domachevsky, Michal Schnaider Beeri

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)

Abstract Diabetes is associated with cognitive decline, but the underlying mechanisms are complex and their relationship with Alzheimer’s Disease biomarkers is not fully understood. We assessed the association of small vessel disease (SVD) and amyl

Externí odkaz: https://doaj.org/article/e0f3cc533aef457c92543aaa7d8b33b0

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Akademický článek

The association between regional adiposity, cognitive function, and dementia-related brain changes: a systematic review

Autor: Ethel Boccara, Sapir Golan, Michal Schnaider Beeri

Publikováno v: Frontiers in Medicine, Vol 10 (2023)

BackgroundAdiposity has been previously associated with cognitive impairment and Alzheimer’s disease and related disorders (ADRD). Body mass index (BMI) is the most common measure of global adiposity, but inconsistent results were found since it is

Externí odkaz: https://doaj.org/article/da81055c0a7a4e69bbbffa0a97d5e1ca

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Akademický článek

Alzheimer’s Disease Polygenic Risk Score Is Not Associated With Cognitive Decline Among Older Adults With Type 2 Diabetes

Autor: Sigalit B. Manzali, Eric Yu, Ramit Ravona-Springer, Abigail Livny, Sapir Golan, Yuxia Ouyang, Orit Lesman-Segev, Lang Liu, Ithamar Ganmore, Anna Alkelai, Ziv Gan-Or, Hung-Mo Lin, Anthony Heymann, Michal Schnaider Beeri, Lior Greenbaum

Publikováno v: Frontiers in Aging Neuroscience, Vol 14 (2022)

ObjectivesMultiple risk loci for late-onset Alzheimer’s disease (LOAD) have been identified. Type 2 diabetes (T2D) is a risk factor for cognitive decline, dementia and Alzheimer’s disease (AD). We investigated the association of polygenic risk sc

Externí odkaz: https://doaj.org/article/d3a677050e164a44a61ab23bb5bbd983

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Akademický článek

P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression

Autor: Eilam Yeini, Paula Ofek, Sabina Pozzi, Nitzan Albeck, Dikla Ben-Shushan, Galia Tiram, Sapir Golan, Ron Kleiner, Ron Sheinin, Sahar Israeli Dangoor, Shlomit Reich-Zeliger, Rachel Grossman, Zvi Ram, Henry Brem, Thomas M. Hyde, Prerna Magod, Dinorah Friedmann-Morvinski, Asaf Madi, Ronit Satchi-Fainaro

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)

Glioma-associated microglia/macrophages are central drivers of brain tumor pathology. Here the authors characterize the role of the P-selectin/PSGL-1 axis in the cross-talk between glioblastoma cells and microglia/macrophages and show that the therap

Externí odkaz: https://doaj.org/article/1f79e03ac9e64447af84689d42d725ab

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Akademický článek

Long‐term trajectories and current BMI are associated with poorer cognitive functioning in middle‐aged adults at high Alzheimer's disease risk

Autor: Rebecca K. West, Ramit Ravona‐Springer, Inbal Sharvit‐Ginon, Ithamar Ganmore, Sigalit Manzali, Amir Tirosh, Sapir Golan, Ethel Boccara, Anthony Heymann, Michal Schnaider Beeri

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 13, Iss 1, Pp n/a-n/a (2021)

Abstract Introduction We examined relationships of body mass index (BMI) with cognition in middle‐aged adults at Alzheimer's disease (AD) risk due to parental family history. Methods Participants are offspring of AD patients from the Israel Registr

Externí odkaz: https://doaj.org/article/a70d4fae565240358a73fbd6a7e5556a

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Akademický článek

Sulfonated Amphiphilic Poly(α)glutamate Amine—A Potential siRNA Nanocarrier for the Treatment of Both Chemo-Sensitive and Chemo-Resistant Glioblastoma Tumors

Autor: Adva Krivitsky, Sabina Pozzi, Eilam Yeini, Sahar Israeli Dangoor, Tal Zur, Sapir Golan, Vadim Krivitsky, Nitzan Albeck, Evgeny Pisarevsky, Paula Ofek, Asaf Madi, Ronit Satchi-Fainaro

Publikováno v: Pharmaceutics, Vol 13, Iss 12, p 2199 (2021)

Development of chemo-resistance is a major challenge in glioblastoma (GB) treatment. This phenomenon is often driven by increased activation of genes associated with DNA repair, such as the alkyl-removing enzyme O6-methylguanine-DNA methyltransferase

Externí odkaz: https://doaj.org/article/ad9519e41bd14d16b70db74e4d6f2122

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Stability in BMI over time is associated with a better cognitive trajectory in older adults

Autor: Michal Schnaider, Beeri, Amir, Tirosh, Hung-Mo, Lin, Sapir, Golan, Ethel, Boccara, Mary, Sano, Carolyn W, Zhu

Publikováno v: Alzheimer's & Dementia. 18:2131-2139

Evidence on simultaneous changes in body mass index (BMI) and cognitive decline, which better reflect the natural course of both health phenomena, is limited.We capitalized on longitudinal data from 15,977 initially non-demented elderly from the Alzh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d66d3be86ce3194586a9f23142e15c
https://doi.org/10.1002/alz.12525

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