Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Saoussen Ben Halima"'
Autor:
Saoussen Ben Halima, Sabyashachi Mishra, K. Muruga Poopathi Raja, Michael Willem, Antonio Baici, Kai Simons, Oliver Brüstle, Philipp Koch, Christian Haass, Amedeo Caflisch, Lawrence Rajendran
Publikováno v:
Cell Reports, Vol 14, Iss 9, Pp 2127-2141 (2016)
Development of disease-modifying therapeutics is urgently needed for treating Alzheimer disease (AD). AD is characterized by toxic β-amyloid (Aβ) peptides produced by β- and γ-secretase-mediated cleavage of the amyloid precursor protein (APP). β
Externí odkaz:
https://doaj.org/article/6c9d943bb8c946c6b2aa849229f67a4c
Autor:
Mikael Simons, Lawrence Rajendran, Sudharshan R, Silva Hećimović, Ali Jawaid, Udayar, Rosa C. Paolicelli, Thakur G, Decressac M, Jitin Bali, Dominko K, Milon Mondal, Malnar M, Rudiyanto Gunawan, Judith Klumperman, Philipp Koch, Oliver Brüstle, Roger M. Nitsch, Saoussen Ben Halima, Manesso E, Vadodaria Kc, Constance S. Petit, Paul E. Schulz, Shawn M. Ferguson, Tara L. Spires-Jones, Makis Tzioras
SummaryExtra-cellular accumulation of Amyloid-β (Aβ) plaques is causatively associated with Alzheimer’s disease (AD). However, mechanisms that mediate the pre-pathological state of amyloid plaque formation remain elusive. Here, using paired RNAi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04e058a0a7e49a19c4851e00f29c13e5
https://doi.org/10.1101/2020.11.13.381186
https://doi.org/10.1101/2020.11.13.381186
Autor:
Michael Willem, Sabyashachi Mishra, Amedeo Caflisch, Lawrence Rajendran, Philipp Koch, Kai Simons, Christian Haass, Antonio Baici, Oliver Brüstle, Saoussen Ben Halima, K. Muruga Poopathi Raja
Publikováno v:
Cell Reports, Vol 14, Iss 9, Pp 2127-2141 (2016)
Cell reports 14(9), 2127-2141 (2016). doi:10.1016/j.celrep.2016.01.076
Cell Reports
Cell reports 14(9), 2127-2141 (2016). doi:10.1016/j.celrep.2016.01.076
Cell Reports
SummaryDevelopment of disease-modifying therapeutics is urgently needed for treating Alzheimer disease (AD). AD is characterized by toxic β-amyloid (Aβ) peptides produced by β- and γ-secretase-mediated cleavage of the amyloid precursor protein (A
Publikováno v:
Journal of Biological Chemistry. 286:2762-2773
Neurexins (NRXNs) are synaptic cell adhesion molecules having essential roles in the assembly and maturation of synapses into fully functional units. Immunocytochemical and electrophysiological studies have shown that specific binding across the syna
β-secretase, a key enzyme involved in amyloid-β generation, is an attractive candidate for Alzheimer's disease therapy. Transition-state inhibitors of β-secretase are designed to achieve specificity. However, these inhibitors bind only to the acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47234c50c58db67a03acf50bd82f82b7
https://www.zora.uzh.ch/id/eprint/49536/
https://www.zora.uzh.ch/id/eprint/49536/
Autor:
Boas Felmy, Jitin Bali, Lawrence Rajendran, Saoussen Ben Halima, Zoë V. Goodger, Sebastian Zurbriggen
Publikováno v:
Annals of Indian Academy of Neurology
Alzheimer's disease (AD) is the most common form of neurodegenerative disease. A characteristic feature of the disease is the presence of amyloid-β (Aβ) which either in its soluble oligomeric form or in the plaque-associated form is causally linked