Výsledky vyhledávání - "Saori Miyauchi"

α-1-C-Butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a Second-Generation Iminosugar-Based Oral α-Glucosidase Inhibitor for Improving Postprandial Hyperglycemia

Autor: Yuichi Yoshimura, Yoshihiro Natori, Erina Hayashi, Atsushi Kato, Hiroki Takahata, Saori Miyauchi, Robert J. Nash, Jun Koseki, Izumi Nakagome, Hideyuki Shimaoka, Isao Adachi, Tatsushi Imahori, Shuichi Hirono

Publikováno v: Journal of Medicinal Chemistry. 55:10347-10362

We report on the synthesis and the biological evaluation of a series of α-1-C-alkylated 1,4-dideoxy-1,4-imino-l-arabinitol (LAB) derivatives. The asymmetric synthesis of the derivatives was achieved by asymmetric allylic alkylation, ring-closing met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc7631ee12680f7acebb279df47dba8
https://doi.org/10.1021/jm301304e

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Docking and SAR studies of d- and l-isofagomine isomers as human β-glucocerebrosidase inhibitors

Autor: Isao Adachi, Noriko Kato, Atsushi Kato, Robert J. Nash, Saori Miyauchi, Izumi Nakagome, Shuichi Hirono, Hiroki Takahata, Yuichi Yoshimura

Publikováno v: Bioorganic & Medicinal Chemistry. 19:3558-3568

We report the structure–activity relationship of a series of d -, and l -isofagomine and fagomine isomers as glycosidase inhibitors. Our study revealed that a positive charge at the anomeric position of d -isofagomines enhanced the potency toward �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caaf1cf97286c5d7a05bc1b055289e90
https://doi.org/10.1016/j.bmc.2011.04.011

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Synthesis of both enantiomers of hydroxypipecolic acid derivatives equivalent to 5-azapyranuronic acids and evaluation of their inhibitory activities against glycosidases

Autor: Chiaki Ohara, Isao Adachi, Atsushi Kato, Tatsushi Imahori, Hiroki Takahata, Saori Miyauchi, Yukako Saito, Yuichi Yoshimura

Publikováno v: Bioorganic & Medicinal Chemistry. 16:8273-8286

We have synthesized 3-hydroxy- and 3,4,5-trihydroxypipecolic acid derivatives corresponding to 5-aza derivatives of uronic acids and evaluated their inhibitory activities against various glycosidases including β-glucuronidase. Compounds 4 and 5 were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc86528b796c972d419054648dd3f71
https://doi.org/10.1016/j.bmc.2008.06.016

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Iminosugars from Baphia nitida Lodd

Autor: Atsushi Kato, Yuka Minoshima, Robert J. Nash, Naoki Asano, Alison A. Watson, Noriko Kato, Saori Miyauchi, Isao Adachi, Kyoko Ikeda

Publikováno v: Phytochemistry. 69:1261-1265

Chromatographic separation of the 50% aqueous EtOH extract of the leaves of the African medicinal tree Baphia nitida resulted in isolation of 10 iminosugars. The plant contained 2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine (DMDP) as a major alkal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa569752d6cf8855eaae8b60512fd231
https://doi.org/10.1016/j.phytochem.2007.11.018

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Scalable syntheses of both enantiomers of DNJNAc and DGJNAc from glucuronolactone: the effect of N-alkylation on hexosaminidase inhibition

Autor: Daniel Best, Benjamin James Ayers, George W. J. Fleet, Atsushi Kato, Saori Miyauchi, Shinpei Nakagawa, José M. García Fernández, Matilde Aguilar-Moncayo, Elizabeth V. Crabtree, Francis Xavier Wilson, Carmen Ortiz Mellet, Andreas F. G. Glawar, Terry D. Butters

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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The efficient scalable syntheses of 2-acetamido-1,2-dideoxy-D-galacto-nojirimycin (DGJNAc) and 2-acetamido-1,2-dideoxy-D-gluco-nojirimycin (DNJNAc) from D-glucuronolactone, as well as of their enantiomers from L-glucuronolactone, are reported. The ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd26b293f95ba5d17b9269e9c110dd9
https://pubmed.ncbi.nlm.nih.gov/22736508

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