Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Saori, Morota"'
Autor:
Johannes K. Ehinger, Sarah Piel, Rhonan Ford, Michael Karlsson, Fredrik Sjövall, Eleonor Åsander Frostner, Saori Morota, Robert W. Taylor, Doug M. Turnbull, Clive Cornell, Steven J. Moss, Carsten Metzsch, Magnus J. Hansson, Hans Fliri, Eskil Elmér
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Mitochondrial complex I deficiency is the most common respiratory chain defect in mitochondrial disease in children and currently there is no effective treatment. In this study, the authors show that succinate prodrugs can alleviate metabolic decompe
Externí odkaz:
https://doaj.org/article/065e786aabe24902981472f3415f76d9
Autor:
Mitsuru Ishikawa, Takeshi Aoyama, Shoichiro Shibata, Takefumi Sone, Hiroyuki Miyoshi, Hirotaka Watanabe, Mari Nakamura, Saori Morota, Hiroyuki Uchino, Andrew S. Yoo, Hideyuki Okano
Publikováno v:
Cells, Vol 9, Iss 3, p 532 (2020)
Obtaining differentiated cells with high physiological functions by an efficient, but simple and rapid differentiation method is crucial for modeling neuronal diseases in vitro using human pluripotent stem cells (hPSCs). Currently, methods involving
Externí odkaz:
https://doaj.org/article/1c96d6775aaa44be9c35851c261e3bb7
Autor:
Roland Månsson, Magnus J. Hansson, Saori Morota, Hiroyuki Uchino, Christine T. Ekdahl, Eskil Elmér
Publikováno v:
Neurobiology of Disease, Vol 25, Iss 1, Pp 198-205 (2007)
Minocycline has been shown to be neuroprotective in ischemic and neurodegenerative disease models and could potentially be relevant for clinical use. We revisited the hypothesis that minocycline acts through direct inhibition of calcium-induced mitoc
Externí odkaz:
https://doaj.org/article/ed85989ce8024ef4a921e232053d03b8
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97673 (2014)
BACKGROUND: The levels of nitric oxide (NO) and various cytokines are known to be increased during sepsis. These signaling molecules could potentially act as regulators and underlie the enhancement of mitochondrial function described in the later pha
Externí odkaz:
https://doaj.org/article/403a782486824cdb8a57858f9f014e2a
Autor:
Saori Morota, Theodor Manolopoulos, Atli Eyjolfsson, Per-Ola Kimblad, Per Wierup, Carsten Metzsch, Sten Blomquist, Magnus J Hansson
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67747 (2013)
The objective of the present study was to validate the presence and explore the characteristics of mitochondrial permeability transition (mPT) in isolated mitochondria from human heart tissue in order to investigate if previous findings in animal mod
Externí odkaz:
https://doaj.org/article/8e10360ab3b84d54be29f3c1f62f5743
Autor:
Hiroyuki Miyoshi, Hirotaka Watanabe, Hideyuki Okano, Takefumi Sone, Mari Nakamura, Takeshi Aoyama, Mitsuru Ishikawa, Hiroyuki Uchino, Andrew S. Yoo, Saori Morota, Shoichiro Shibata
Publikováno v:
Cells
Cells, Vol 9, Iss 3, p 532 (2020)
Volume 9
Issue 3
Cells, Vol 9, Iss 3, p 532 (2020)
Volume 9
Issue 3
Obtaining differentiated cells with high physiological functions by an efficient, but simple and rapid differentiation method is crucial for modeling neuronal diseases in vitro using human pluripotent stem cells (hPSCs). Currently, methods involving
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f0f450da8a33fe79354914cdeab3e9
https://pubmed.ncbi.nlm.nih.gov/32106535
https://pubmed.ncbi.nlm.nih.gov/32106535
Autor:
Sigurður E. Marelsson, Anders Oldfors, Vineta Fellman, Eleonor Åsander Frostner, Fredrik Sjövall, Magnus Hansson, Johannes K. Ehinger, Johan Lundgren, Eskil Elmér, Saori Morota, Emil Westerlund, Niklas Darin
Publikováno v:
Pediatric Research. 83:455-465
BackgroundDiagnosing mitochondrial disease (MD) is a challenge. In addition to genetic analyses, clinical practice is to perform invasive procedures such as muscle biopsy for biochemical and histochemical analyses. Blood cell respirometry is rapid an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9847c2748f8b7367ebc2e2190688b221
https://doi.org/10.1038/pr.2017.250
https://doi.org/10.1038/pr.2017.250
Publikováno v:
Journal of Neurology. 262:1493-1503
Mitochondrial dysfunction is implicated in amyotrophic lateral sclerosis, where the progressive degeneration of motor neurons results in muscle atrophy, paralysis and death. Abnormalities in both central nervous system and muscle mitochondria have pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02d53d6b866f665d2788e0547ab4ac5
https://doi.org/10.1007/s00415-015-7737-0
https://doi.org/10.1007/s00415-015-7737-0
Autor:
Hiroyuki Uchino, Kusuki Nishioka, Kenya Nishioka, Yu Nakatani, Daisuke Hasegawa, Ko-ichi Kawahara, Naomi Hara, Eskil Elmér, Naoko Yagishita, Hiroko Kokuba, Fukami Nakajima, Tomoko Saito-Fujita, Satoko Aratani, Toshihiro Nakajima, Tomoo Sato, Saori Morota, Magnus Hansson, Itsuro Higuchi, Katsuko Sudo, Eiichi Sato, Hidetoshi Fujita, Masahiko Usui, Natsumi Araya, Chie Usui, Yoshihisa Yamano, Masato Inazu, Ikuro Maruyama
Publikováno v:
The EMBO Journal. 34:1042-1055
Obesity is a major global public health problem, and understanding its pathogenesis is critical for identifying a cure. In this study, a gene knockout strategy was used in post-neonatal mice to delete synoviolin (Syvn)1/Hrd1/Der3, an ER-resident E3 u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7b92ca7b69c1e6a55fbbc7b3d6ad62d
https://doi.org/10.15252/embj.201489897
https://doi.org/10.15252/embj.201489897
Publikováno v:
BMC Cell Biology. 2013, Vol. 14 Issue 1, p1-10. 10p.