Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Saoirse E, O'Sullivan"'
Autor:
John Noone, Mary F. Rooney, Marilena Karavyraki, Andrew Yates, Saoirse E. O’Sullivan, Richard K. Porter
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1580 (2023)
Cachexia syndrome, leading to reduced skeletal muscle and fat mass, is highly prevalent in cancer patients, resulting in further negative implications for these patients. To date, there is no approved therapy for cachexia syndrome. The objective of t
Externí odkaz:
https://doaj.org/article/66bc15e3d2ff4348838f1d516973fd4b
Publikováno v:
Medical Cannabis and Cannabinoids, Pp 1-11 (2021)
Introduction: Cannabidiol (CBD) can be isolated from Cannabis sativa L. or synthetically produced. The aim of this study was to compare the in vitro effects of purified natural and synthetic CBD to establish any pharmacological differences or superio
Externí odkaz:
https://doaj.org/article/6535799180154992a8c0aef3906306ba
Autor:
Annastazia E. Learoyd, Ryan Calmus, Chelsea N. Cunningham, Tim J. England, Tracy D. Farr, Kevin C.F. Fone, David A. Kendall, Saoirse E. O’Sullivan, Rebecca C. Trueman
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Background: Animal models of stroke have been criticised as having poor predictive validity, lacking risk factors prevalent in an aging population. This pilot study examined the development of comorbidities in a combined aged and high-fat diet model,
Externí odkaz:
https://doaj.org/article/6d17c5da6d754bc2a211303e3f26d30a
Autor:
Sophie A. Millar, Stephen G. John, Christopher W. McIntyre, Vera Ralevic, Susan I. Anderson, Saoirse E. O'Sullivan
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Osteocalcin (OCN) is a bone-derived protein that is detected within human calcified vascular tissue. Calcification is particularly prevalent in chronic kidney disease (CKD) patients but the role of OCN in calcification, whether active or passive, has
Externí odkaz:
https://doaj.org/article/1ab0a2ed279943f686423a5b61e5da5b
Autor:
Timothy J. England, Amanda Hedstrom, Saoirse E. O'Sullivan, Lisa Woodhouse, Ben Jackson, Nikola Sprigg, Philip M. Bath
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 23 (2019)
Background Repeated episodes of limb ischemia and reperfusion (remote ischemic conditioning [RIC]) may protect the brain from ischemic reperfusion injury. Methods and Results We performed a phase IIb blinded dose‐escalation sham‐controlled trial
Externí odkaz:
https://doaj.org/article/a58605eef1ae48958dc6d333b4788cac
Publikováno v:
PeerJ, Vol 7, p e7139 (2019)
Bone-derived factors that demonstrate extra-skeletal functions, also termed osteokines, are fast becoming a highly interesting and focused area of cross-disciplinary endocrine research. Osteocalcin (OCN), fibroblast growth factor-23 (FGF23) and lipoc
Externí odkaz:
https://doaj.org/article/03f0d941af2b4bb983e8d4527e448d54
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Structural alterations and breakdown of the blood brain barrier (BBB) is often a primary or secondary consequence of disease, resulting in brain oedema and the transport of unwanted substances into the brain. It is critical that effective in vitro mo
Externí odkaz:
https://doaj.org/article/576c85d75e0040d5a8e59ee357244cf8
Publikováno v:
Cannabis and Cannabinoid Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdabcb2db76c931f6910055bb7c10c04
https://doi.org/10.1089/can.2022.0263
https://doi.org/10.1089/can.2022.0263
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Background: Cannabidiol is being pursued as a therapeutic treatment for multiple conditions, usually by oral delivery. Animal studies suggest oral bioavailability is low, but literature in humans is not sufficient. The aim of this review was to colla
Externí odkaz:
https://doaj.org/article/f29394b0b4e94723b66fa1cdad6d10f8
Autor:
Nicole L. Stone, Sophie A. Millar, Philip J. J. Herrod, David A. Barrett, Catharine A. Ortori, Valerie A. Mellon, Saoirse E. O’Sullivan
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 12 (2018)
The euphoric feeling described after running is, at least in part, due to increased circulating endocannabinoids (eCBs). eCBs are lipid signaling molecules involved in reward, appetite, mood, memory and neuroprotection. The aim of this study was to i
Externí odkaz:
https://doaj.org/article/965aad594dec4f6fbe79b4f533d9df4b