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Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only.

Autor: Grimbert, Lucile¹ (AUTHOR), Sanz, Maria-Nieves¹ (AUTHOR), Gressette, Mélanie¹ (AUTHOR), Rucker-Martin, Catherine² (AUTHOR), Novotova, Marta³ (AUTHOR), Solgadi, Audrey⁴ (AUTHOR), Karoui, Ahmed¹ (AUTHOR), Gomez, Susana¹ (AUTHOR), Bedouet, Kaveen¹ (AUTHOR), Jacquet, Eric⁵ (AUTHOR), Lemaire, Christophe^1,6 (AUTHOR), Veksler, Vladimir¹ (AUTHOR), Mericskay, Mathias¹ (AUTHOR), Ventura-Clapier, Renée¹ (AUTHOR), Piquereau, Jérôme¹ (AUTHOR) jerome.piquereau@universite-paris-saclay.fr, Garnier, Anne¹ (AUTHOR)

Publikováno v: Biology of Sex Differences. 9/17/2021, Vol. 12 Issue 1, p1-24. 24p.

AMPK in skeletal muscle function and metabolism

Autor: Kjøbsted, Rasmus, Hingst, Janne, Fentz, Joachim, Foretz, Marc, Sanz, Maria-Nieves, Pehmøller, Christian, Shum, Michael, Marette, André, Mounier, Remi, Treebak, Jonas, Wojtaszewski, Jørgen, Viollet, Benoit, Lantier, Louise

Publikováno v: FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2018, 32 (4), pp.1741-1777. ⟨10.1096/fj.201700442R⟩
The FASEB Journal
FASEB Journal, 2018, 32 (4), pp.1741-1777. ⟨10.1096/fj.201700442R⟩

International audience; Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions. AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning anabolic and catabolic pathways. AMPK's rol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d79a62befaae939bfa77a1b85cd24d51
https://www.hal.inserm.fr/inserm-02348651/document

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AMPK in skeletal muscle function and metabolism.

Autor: Kjøbsted R; Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark., Hingst JR; Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark., Fentz J; Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark., Foretz M; INSERM, Unité 1016, Institut Cochin, Paris, France.; Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche (UMR) 8104, Paris, France.; Université Paris Descartes, Sorbonne Paris Cité, Paris, France., Sanz MN; Department of Cardiovascular Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland, and.; Department of Biomedical Research, University of Bern, Bern, Switzerland., Pehmøller C; Internal Medicine Research Unit, Pfizer Global Research and Development, Cambridge, Massachusetts, USA., Shum M; Axe Cardiologie, Quebec Heart and Lung Research Institute, Laval University, Québec, Canada.; Institute for Nutrition and Functional Foods, Laval University, Québec, Canada., Marette A; Axe Cardiologie, Quebec Heart and Lung Research Institute, Laval University, Québec, Canada.; Institute for Nutrition and Functional Foods, Laval University, Québec, Canada., Mounier R; Institute NeuroMyoGène, Université Claude Bernard Lyon 1, INSERM Unité 1217, CNRS UMR, Villeurbanne, France., Treebak JT; Section of Integrative Physiology, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Wojtaszewski JFP; Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark., Viollet B; INSERM, Unité 1016, Institut Cochin, Paris, France.; Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche (UMR) 8104, Paris, France.; Université Paris Descartes, Sorbonne Paris Cité, Paris, France., Lantier L; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.; Mouse Metabolic Phenotyping Center, Vanderbilt University, Nashville, Tennessee, USA.

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2018 Apr; Vol. 32 (4), pp. 1741-1777. Date of Electronic Publication: 2018 Jan 05.