Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro

Autor: Samuel A. Watson, James Duff, Ifigeneia Bardi, Magdalena Zabielska, Santosh S. Atanur, Richard J. Jabbour, André Simon, Alejandra Tomas, Ryszard T. Smolenski, Sian E. Harding, Filippo Perbellini, Cesare M. Terracciano

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

Cultured adult cardiac tissue undergoes rapid dedifferentiation, which hinders chronic in vitro studies. Here the authors investigate biomimetic electromechanical stimulation of adult myocardial slices applying different preload conditions, identifyi

Externí odkaz: https://doaj.org/article/3121859689094ac79bf739761e7891fe

Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells

Autor: Jane A. Mitchell, Ricky Vaja, Blerina Ahmetaj-Shala, Nicholas S. Kirkby, Peter M. George, Santosh S. Atanur

Publikováno v: JACC: Basic to Translational Science

Objectives: To obtain mechanistic insight into COVID-19 within a cardiovascular setting. Background: Thrombosis and vascular dysfunction are part of the complex pathology seen in severe COVID-19 and advancing age is the most significant risk factor.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac3c81f45036514a8b648435b093b0b
https://doi.org/10.1016/j.jacbts.2020.09.010

Cap analysis of gene expression (CAGE) sequencing reveals alternative promoter usage in complex disease

Autor: Sonal Dahale, Sebastiaan van Heesch, Jorge Ruiz-Orera, Michal Pravenec, Norbert Hubner, Jan Silhavy, Santosh S. Atanur

The role of alternative promoter usage in tissue specific gene expression has been well established, however, its role in complex diseases is poorly understood. We performed cap analysis of gene expression (CAGE) tag sequencing from the left ventricl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d0f7cd53ae4715fee8857d733f4d111
https://doi.org/10.1101/2021.08.28.458014

Impulsivity is a heritable trait in rodents and associated with a novel quantitative trait locus on chromosome 1

Autor: Timothy J. Aitman, Margarita Moreno, Oliver Staehlin, Bianca Jupp, Stephanie Taylor, Silvia Pitzoi, Wolfgang H. Sommer, Santosh S. Atanur, Jeffrey W. Dalley, Emma S J Robinson, Rainer Spanagel, Prashant K. Srivastava, Enrico Petretto, Gunter Schumann, Norbert Hubner, Adam C. Mar, Trevor W. Robbins, Barry J. Everitt, YP Oliver, Emily R Jordan, Kathrin Saar

Publikováno v: Jupp, B, Pitzoi, S, Petretto, E, Mar, A C, Oliver, Y P, Jordan, E R, Taylor, S, Atanur, S, Srivastava, P K, Saar, K, Hübner, N, Sommer, W, Staehlin, O, Spanagel, R, Robinson, E S, Schumann, G, Moreno, M, Everitt, B J, Robbins, T W, Aitman, T J & Dalley, J W 2020, ' Impulsivity is a heritable trait in rodents and associated with a novel quantitative trait locus on chromosome 1 ', Scientific Reports . https://doi.org/10.1038/s41598-020-63646-9
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports

Impulsivity describes the tendency to act prematurely without appropriate foresight and is symptomatic of a number of neuropsychiatric disorders. Although a number of genes for impulsivity have been identified, no study to date has carried out an unb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff7ae4be231a2a8f7eff0a9a2eb84314
https://doi.org/10.1038/s41598-020-63646-9

5330A novel platform to maintain adult cardiac tissue in vitro: myocardial slices and electromechanical stimulation with physiological preload

Autor: Cesare M. Terracciano, Ryszard T. Smolenski, James Duff, Richard J. Jabbour, Santosh S. Atanur, Magdalena A. Zabielska, Samuel A. Watson, Filippo Perbellini, Ifigeneia Bardi, Sian E. Harding

Publikováno v: European Heart Journal. 39

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc05f8dc50f3c5ca51f6101088a80d36
https://doi.org/10.1093/eurheartj/ehy566.5330