Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Santosh Nandan"'
Autor:
Maheshkumar R. Borkar, Evans C. Coutinho, Jisha Manniyodath, Dipankar Chatterji, Jayashree Puttur, Santosh Nandan, Harish K M Nagaraj
Publikováno v:
Medicinal Chemistry. 15:28-37
Background: The treatment of a bacterial infection when the bacterium is growing in a biofilm is a vexed issue. This is because the bacteria in a biofilm behaves differently compared to the individual planktonic free-form. As a result, traditional an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb26e51b131948c38c50b6c222fdf8b2
https://doi.org/10.2174/1573406414666180525075755
https://doi.org/10.2174/1573406414666180525075755
Autor:
Evans C. Coutinho, Rohan Chitral, Kavita Raikuvar, Afreen A. Khan, Jayashree Puttur, Santosh Nandan, Krishna R. Iyer, Sohal Satish, Amitkumar Kori, Deepali Desle, Tanya Parish, Basantkumar Sharma, Aaron Korkegian, Elvis A. F. Martis
Publikováno v:
Molecular diversity. 26(1)
N-furfuryl piperazine ureas disclosed by scientists at GSK Tres Cantos were chosen as antimycobacterial hits from a phenotypic whole-cell screen. Bioisosteric replacement of the furan ring in the GSK Tres Cantos molecules with a phenyl ring led to mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d247c02cd904109626fb5be9d7cf8339
https://pubmed.ncbi.nlm.nih.gov/33385288
https://pubmed.ncbi.nlm.nih.gov/33385288
Autor:
Scott G. Franzblau, Ravindra D. Wavhale, Krishna R. Iyer, Santosh Nandan, Kavita Raikuvar, Elvis A. F. Martis, Katarzyna Macegoniuk, Premlata K. Ambre, Łukasz Berlicki, Evans C. Coutinho, Baojie Wan
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:4835-4844
BM212 [1,5-diaryl-2-methyl-3-(4-methylpiperazin-1-yl)-methyl-pyrrole] is a pyrrole derivative with strong inhibitory activity against drug resistant Mycobacterium tuberculosis and mycobacteria residing in macrophages. However, it was not pursued beca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0abdc62afa494f485a3c808293245c3
https://doi.org/10.1016/j.bmc.2017.07.034
https://doi.org/10.1016/j.bmc.2017.07.034
Publikováno v:
Handbook of Research on Medicinal Chemistry ISBN: 9781315207414
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::680ab4f3f16cbe58e8576fdcbfdffde4
https://doi.org/10.1201/9781315207414-1
https://doi.org/10.1201/9781315207414-1
Publikováno v:
Applied Catalysis A: General. 478:241-251
An efficient, cost-effective use of Raney nickel (R-Ni) a widely used industrial catalyst for N-alkylation using alcohols is highlighted here. The work describes the scope and capability of R-Ni in hydrogen autotransfer reactions enabling its widespr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::942ecfc01f10964e5e89e80b89884b10
https://doi.org/10.1016/j.apcata.2014.04.009
https://doi.org/10.1016/j.apcata.2014.04.009
Publikováno v:
Journal of Emerging Infectious Diseases. 1
Dengue virus (DENV) is extremely difficult to eradicate and the virus is responsible for a significant disease burden globally wherein several million people are mortally affected. In the quest for developing a treatment of this disease, scientists h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4beae0ddefa440d25389fa95b444412
https://doi.org/10.4172/2472-4998.1000108
https://doi.org/10.4172/2472-4998.1000108
Autor:
Krishna R. Iyer, Raghuvir R. S. Pissurlenkar, Rakesh C. Chandarana, Elvis A. F. Martis, Mushtaque S. Shaikh, Jacinta S. D’Souza, Evans C. Coutinho, Premlata K. Ambre, Santosh Nandan
There is a need for continued development of acetylcholinesterase (AChE) inhibitors that could prolong the life of acetylcholine in the synaptic cleft and also prevent the aggregation of amyloid peptides associated with Alzheimer’s disease. The lac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79fc4c02550525ac36d11eef1b88d91b
Autor:
Kale Manoj Ganpat, Dwarakanath Prahlad, P. Shahul Hameed, B. Bhaskar, Santosh Nandan, Vikas Patil, Anandkumar Raichurkar, Meenakshi Balganesh
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(9)
Novel triazolopyrimidine acylsulfonamides class of antimycobacterial agents, which are mycobacterial acetohydroxyacid synthase (AHAS) inhibitors were designed by hybridization of known AHAS inhibitors such as sulfonyl urea and triazolopyrimidine sulf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39041d52ff1be031d4e9a7c1f2b3f9a2
https://pubmed.ncbi.nlm.nih.gov/24703230
https://pubmed.ncbi.nlm.nih.gov/24703230
Autor:
Byron Caughey, Gregory J. Raymond, Bruce Chesebro, Jon H. Come, Santosh Nandan, David A. Kocisko, Suzette A. Priola, Peter T. Lansbury
Publikováno v:
Bovine Spongiform Encephalopathy ISBN: 9781461275275
The formation of the abnormal protease-resistant, amyloidogenic isoform of PrP (PrP-res) appears to play a central role in the pathogenesis of scrapie and other transmissible spongiform encephalopathies (TSEs). Thus, it is important to understand the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::273209a01c2cbc23bd14f340e82e3a03
https://doi.org/10.1007/978-1-4612-2406-8_22
https://doi.org/10.1007/978-1-4612-2406-8_22
Autor:
David A. Kocisko, Gregory J. Raymond, Santosh Nandan, Richard A. Bessen, Byron Caughey, Peter T. Lansbury
Publikováno v:
Nature. 375(6533)
THE infectious agents causing scrapie and other transmissible spon-giform encephalopathies have been postulated to consist solely of the protease-resistant form of prion protein (PrPSc)1–6. One unprecedented requirement of the protein-only model is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3df301a01d77d98d49eccf5518a47d
https://pubmed.ncbi.nlm.nih.gov/7791890
https://pubmed.ncbi.nlm.nih.gov/7791890