Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Santosh Lakshmi Gande"'
Autor:
Elke Stirnal, Harald Schwalbe, Isam Elamri, Santosh Lakshmi Gande, Chahinez Abdellaoui, Jasleen Kaur Bains, Katharina F. Hohmann, Josef Wachtveitl
Publikováno v:
Journal of the American Chemical Society. 143:10596-10603
Photocleavable protecting groups (PPGs) play a pivotal role in numerous studies. They enable controlled release of small effector molecules to induce biochemical function. The number of PPGs attached to a variety of effector molecules has grown rapid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62cae3a34983d03b4c49e00f68389dc5
https://doi.org/10.1021/jacs.1c02817
https://doi.org/10.1021/jacs.1c02817
Autor:
Clemens Glaubitz, Josef Wachtveitl, Jiafei Mao, Krishna Saxena, Nina Kubatova, Santosh Lakshmi Gande, Harald Schwalbe, Carl Elias Eckert
Publikováno v:
Angewandte Chemie (International Ed. in English)
The RHO gene encodes the G‐protein‐coupled receptor (GPCR) rhodopsin. Numerous mutations associated with impaired visual cycle have been reported; the G90D mutation leads to a constitutively active mutant form of rhodopsin that causes CSNB diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8706e5a13d3cd7cd9f3d87c45ec5d4da
https://doi.org/10.1002/anie.202003671
https://doi.org/10.1002/anie.202003671
Autor:
Fabian Hiller, Christina Lamers, Santosh Lakshmi Gande, Sridhar Sreeramulu, Anna Aagaard, Lisa Wissler, Verena Linhard, Krister Bamberg, Denis Kudlinzki, Krishna Saxena, Ewa Nilsson, Harald Schwalbe, Manfred Schubert-Zsilavecz, Niek Dekker, Daniel Merk
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
The bile acid-sensing transcription factor farnesoid X receptor (FXR) regulates multiple metabolic processes. Modulation of FXR is desired to overcome several metabolic pathologies but pharmacological administration of full FXR agonists has been plag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92025ab279f1dcbd4f7494941464f594
http://link.springer.com/article/10.1038/s41467-019-10853-2
http://link.springer.com/article/10.1038/s41467-019-10853-2
Autor:
Tatjana Schamber, Kamal Azzaoui, Nusrat S. Qureshi, Boris Fürtig, Oliver Binas, Jason N Martins, Marcel J. J. Blommers, Daniel Hymon, Alix Tröster, Jasleen Kaur Bains, Christian Richter, Harald Schwalbe, Elke Stirnal, Andreas Oxenfarth, Julia Wirmer-Bartoschek, Hannes Berg, Anna Wacker, Robbin Schnieders, Tom Landgraf, Vanessa de Jesus, Santosh Lakshmi Gande, Sridhar Sreeramulu, Thomas Biedenbänder, Maria Alexandra Wirtz Martin, Albrecht Eduard Völklein, Anna Niesteruk
Publikováno v:
ChemBioChem
Chembiochem
Chembiochem
We report here on the nuclear magnetic resonance (NMR) 19 F screening of 14 RNA targets with different secondary and tertiary structure to systematically assess druggability of RNAs. Our RNA targets include representative bacterial riboswitches that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57aa4c3116edf518bcf60528cde01fe5
Autor:
Guillaume Médard, Xiaofeng Liu, Denis Kudlinzki, Jonas Lohse, Stephanie Heinzlmeir, Bernhard Kuster, Krishna Saxena, Tobias Treiber, Verena Linhard, Santosh Lakshmi Gande, Sridhar Sreeramulu, Harald Schwalbe, Mathias Wilhelm
Publikováno v:
ChemMedChem. 12:999-1011
The receptor tyrosine kinase EPHA2 has gained attention as a therapeutic drug target for cancer and infectious diseases. However, EPHA2 research and EPHA2-based therapies have been hampered by the lack of selective small-molecule inhibitors. Herein w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e9fa30d43984787f6183e3f185eb5f
https://doi.org/10.1002/cmdc.201700217
https://doi.org/10.1002/cmdc.201700217
Autor:
Verena Linhard, Stephanie Heinzlmeir, Denis Kudlinzki, Bernhard Kuster, Santosh Lakshmi Gande, Sridhar Sreeramulu, Arne Skerra, Andreas J. Reichert, Krishna Saxena, Harald Schwalbe
Publikováno v:
ChemBioChem. 17:2257-2263
The receptor tyrosine kinase EPHA2 is overexpressed in several cancer entities (breast, head and neck, non-small cell lung cancer). Small molecule-based inhibition of the activity of the EPHA2 kinase domain (KD) has been seen as an important strategy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26ea0931b0696cc02f6cf1246986afd
https://doi.org/10.1002/cbic.201600483
https://doi.org/10.1002/cbic.201600483
Autor:
Evelyn Süß, Klaus Strebhardt, Isabelle Béquignon, Mourad Sanhaji, Larissa Pietsch, Birgit Caspar, Denis Kudlinzki, Harald Schwalbe, Krishna Saxena, Ricardo M. Biondi, Santosh Lakshmi Gande, Sridhar Sreeramulu, Monika Raab, Amanda K. Herbrand
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
The Polo-like kinases (Plks) are an evolutionary conserved family of Ser/Thr protein kinases that possess, in addition to the classical kinase domain at the N-terminus, a C-terminal polo-box domain (PBD) that binds to phosphorylated proteins and modu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165dfbae0d805a189f356c1baece7a86
https://pubs.acs.org/doi/10.1021/acschembio.7b01078
https://pubs.acs.org/doi/10.1021/acschembio.7b01078
Autor:
Stephanie Heinzlmeir, Alix Tröster, Bernhard Kuster, Benedict-Tilman Berger, Amir H. Nasiri, Guillaume Médard, Michael Bolte, Susanne Müller, Denis Kudlinzki, Verena Linhard, Harald Schwalbe, Santosh Lakshmi Gande, Sridhar Sreeramulu, Krishna Saxena
Publikováno v:
ChemMedChem
Erythropoietin-producing hepatocellular (EPH) receptors are transmembrane receptor tyrosine kinases. Their extracellular domains bind specifically to ephrin A/B ligands, and this binding modulates intracellular kinase activity. EPHs are key players i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e9e9301314aaeb77c95fa05aad70a39
https://pubmed.ncbi.nlm.nih.gov/29928781
https://pubmed.ncbi.nlm.nih.gov/29928781
Autor:
Verena Linhard, Denis Kudlinzki, Ulrich Schieborr, Krishna Saxena, Harald Schwalbe, Matthias K. Dreyer, Santosh Lakshmi Gande, Sridhar Sreeramulu
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 71:1088-1093
Protein kinases (PKs) are dynamic regulators of numerous cellular processes. Their phosphorylation activity is determined by the conserved kinase core structure, which is maintained by the interaction and dynamics with associated domains or interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9886b8f114533c7fa4288ade445fd9
https://doi.org/10.1107/s2053230x1501242x
https://doi.org/10.1107/s2053230x1501242x
Autor:
Rupert Abele, Krishna Saxena, Volker Dötsch, Santosh Lakshmi Gande, Harald Schwalbe, Sridhar Sreeramulu, Vladimir V. Rogov, Jens Wöhnert, Heinz D. Osiewacz, Verena Linhard, Ulrich Schieborr, Jan Philip Wurm, Denis Kudlinzki, Deep Chatterjee
Publikováno v:
Journal of Biological Chemistry. 290:16415-16430
Low levels of reactive oxygen species (ROS) act as important signaling molecules, but in excess they can damage biomolecules. ROS regulation is therefore of key importance. Several polyphenols in general and flavonoids in particular have the potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9faecea2b171eb5be3e88997bfa294af
https://doi.org/10.1074/jbc.m115.660829
https://doi.org/10.1074/jbc.m115.660829