Structural and Functional Implications of Non-synonymous Mutations in the Spike protein of 2,954 SARS-CoV-2 Genomes

Autor: Nelson-Sathi, Shijulal, Umasankar, PK, Sreekumar, E, Nair, R Radhakrishnan, Joseph, Iype, Chandra Nori, Sai Ravi, Philip, Jamiema Sara, Prasad, Roshny, Navyasree, KV, Ramesh, Shikha, Pillai, Heera, Ghosh, Sanu, Santosh Kumar, TR, Pillai, M. Radhakrishna

Publikováno v: bioRxiv

SARS-CoV-2, the causative agent of COVID-2019 pandemic is an RNA virus prone to mutations. Information on mutations within the circulating strains of the virus is pivotal to understand disease spread and dynamics. Here, we analyse the mutations assoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::86701be1bc71b4a543932555df81c2a0

Mutational landscape and in silico structure models of SARS-CoV-2 spike receptor binding domain reveal key molecular determinants for virus-host interaction.

Autor: Nelson-Sathi S; Corona Research & Intervention Group, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India. shijulalns@rgcb.res.in., Umasankar PK; Corona Research & Intervention Group, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India. umasankarpk@rgcb.res.in., Sreekumar E; Corona Research & Intervention Group, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India., Nair RR; Corona Research & Intervention Group, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India., Joseph I; Corona Research & Intervention Group, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India., Nori SRC; Corona Research & Intervention Group, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India., Philip JS; Corona Research & Intervention Group, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India., Prasad R; Corona Research & Intervention Group, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India., Navyasree KV; Corona Research & Intervention Group, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India., Ramesh S; Corona Research & Intervention Group, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India., Pillai H; Corona Research & Intervention Group, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India., Ghosh S; Corona Research & Intervention Group, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India., Santosh Kumar TR; Corona Research & Intervention Group, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India., Pillai MR; SAGENOME Private Limited, BioNest, Kochi, 683503, India.

Publikováno v: BMC molecular and cell biology [BMC Mol Cell Biol] 2022 Jan 07; Vol. 23 (1), pp. 2. Date of Electronic Publication: 2022 Jan 07.