Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Santosh Khedkar"'
Autor:
Eugenia Kharlampieva, Vasundhara Kain, Subhashini Bolisetty, Kevin A. Ingle, Sumanth D. Prabhu, Fei Liu, Anupam Agarwal, Santosh Khedkar, Ganesh V. Halade, Veronika Kozlovskaya
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Following myocardial infarction (MI), overactive inflammation remodels the left ventricle (LV) leading to heart failure coinciding with reduced levels of 15-epi-Lipoxin A4 (15-epi LXA4). However, the role of 15-epi LXA4 in post-MI acute inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe57c2c176f82ee101388e65ec106f6a
http://link.springer.com/article/10.1038/s41598-017-10441-8
http://link.springer.com/article/10.1038/s41598-017-10441-8
Autor:
Anthony Rosenzweig, Ling Xiao, Santosh Khedkar, Vassilios J. Bezzerides, Aifeng Zhang, Filomena G. Ottaviano, David J. Milan, Shiro Baba, Stacey N. Lynch, Saumya Das, Alan C. Rigby, Katherine Hessler, Bridget Simonson
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports
Scientific Reports
Alterations in sodium flux (INa) play an important role in the pathogenesis of cardiac arrhythmias and may also contribute to the development of cardiomyopathies. We have recently demonstrated a critical role for the regulation of the voltage-gated s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed646555a542b20a210e46e21b0b9f26
Autor:
Vasundhara, Kain, Fei, Liu, Veronika, Kozlovskaya, Kevin A, Ingle, Subhashini, Bolisetty, Anupam, Agarwal, Santosh, Khedkar, Sumanth D, Prabhu, Eugenia, Kharlampieva, Ganesh V, Halade
Publikováno v:
Scientific Reports
Following myocardial infarction (MI), overactive inflammation remodels the left ventricle (LV) leading to heart failure coinciding with reduced levels of 15-epi-Lipoxin A4 (15-epi LXA4). However, the role of 15-epi LXA4 in post-MI acute inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d86a32c429779b03d766ccd09868def7
https://pubmed.ncbi.nlm.nih.gov/28855632
https://pubmed.ncbi.nlm.nih.gov/28855632
Autor:
Dongsheng Zhang, Ji Yoo Lee, Ravi Thadhani, Santosh Khedkar, Peter M. Kang, Mohammed A. Samad, Sangita Choudhury, Alan C. Rigby, S. Ananth Karumanchi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Vitamin D regulates many biological processes, but its clinical utility is limited by its hypercalcemic effect. Using a virtual screening platform to search novel chemical probes that activate the vitamin D signaling, we report discovery of novel non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc252cca7b520e9af93b6d28a995dd2
https://pubmed.ncbi.nlm.nih.gov/28814738
https://pubmed.ncbi.nlm.nih.gov/28814738
Autor:
S. Ananth Karumanchi, Linda C. Hemphill, Alan C. Rigby, Henning Hagmann, A Jank, Oliver A. Cornely, Claudia Kreyssig, Thomas Benzing, Tuelay Kisner, Tom H. Lindner, Stefanie Noack, Angela Kribs, Holger Stepan, Verena Bossung, Peter Mallmann, Santosh Khedkar, W Schaarschmidt, Ravi Thadhani
Publikováno v:
Circulation. 125
Winkler et al raise an interesting point that perhaps lowering of soluble fms-like tyrosine kinase 1 (sFlt-1) may not have been the sole reason for the therapeutic benefit noted in our study,1 and that lowering other substances such as low-density li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ec76958f1ef8e391f8420a94251d042
https://doi.org/10.1161/circulationaha.111.078378
https://doi.org/10.1161/circulationaha.111.078378
Publikováno v:
Molecular informatics. 31(6-7)
A simple and directly applicable 3D-QSAR method, termed Comparative Occupancy Analysis (CoOAn), has been developed. The method is based on the comparison of local occupancies of fragments of an aligned set of molecules in a 3D-grid space. The formali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d10d9b976c00aaed69937212d2a459f
https://pubmed.ncbi.nlm.nih.gov/27477462
https://pubmed.ncbi.nlm.nih.gov/27477462
Autor:
Claudia Kreyssig, Verena Bossung, Tom H. Lindner, Ravi Thadhani, W Schaarschmidt, Angela Kribs, Alan C. Rigby, Peter Mallmann, S. Ananth Karumanchi, Holger Stepan, Stefanie Noack, Santosh Khedkar, Oliver A. Cornely, A Jank, Tuelay Kisner, Linda C. Hemphill, Henning Hagmann, Thomas Benzing
Publikováno v:
Circulation. 124(8)
Background— Targeted therapies to stabilize the clinical manifestations and prolong pregnancy in preeclampsia do not exist. Soluble fms-like tyrosine kinase 1 (sFlt-1), an alternatively spliced variant of the vascular endothelial growth factor rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f8a7d33e308b18c417981c0ffda36a
https://pubmed.ncbi.nlm.nih.gov/26460354
https://pubmed.ncbi.nlm.nih.gov/26460354
Publikováno v:
Current topics in medicinal chemistry. 10(1)
Drug discovery and development is an interdisciplinary, expensive and time-consuming process. Scientific advancements during the past two decades have changed the way pharmaceutical research generate novel bioactive molecules. Advances in computation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd228d5a4927237fed2adc38d462ac4
https://pubmed.ncbi.nlm.nih.gov/19929824
https://pubmed.ncbi.nlm.nih.gov/19929824
Publikováno v:
Journal of Chemical Information & Modeling; Dec2009, Vol. 49 Issue 12, p2695-2707, 13p