Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Santosh G. Valeja"'
Autor:
Zachery R. Gregorich, Huseyin Guner, Wenxuan Cai, Serife Ayaz-Guner, Ying Ge, Santosh G. Valeja, Xiaowen Liu, Albert J. Chen, Ying Peng
Publikováno v:
Molecular & Cellular Proteomics. 15:703-714
Top-down mass spectrometry (MS)-based proteomics is arguably a disruptive technology for the comprehensive analysis of all proteoforms arising from genetic variation, alternative splicing, and posttranslational modifications (PTMs). However, the comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca6901edf0262c70799aeec96a3431c
https://doi.org/10.1074/mcp.o115.054387
https://doi.org/10.1074/mcp.o115.054387
Publikováno v:
Analytical Chemistry. 88:1885-1891
Recent progress in top-down proteomics has led to a demand for mass spectrometry (MS)-compatible chromatography techniques to separate intact proteins using volatile mobile phases. Conventional hydrophobic interaction chromatography (HIC) provides hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ca670720293d660cc7364f01fd50e1
https://doi.org/10.1021/acs.analchem.5b04285
https://doi.org/10.1021/acs.analchem.5b04285
Publikováno v:
Analytical Chemistry. 87:5363-5371
To address the complexity of the proteome in mass spectrometry (MS)-based top-down proteomics, multidimensional liquid chromatography (MDLC) strategies that can effectively separate proteins with high resolution and automation are highly desirable. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c05d30759415f70cdba804d96e6ae096
https://doi.org/10.1021/acs.analchem.5b00657
https://doi.org/10.1021/acs.analchem.5b00657
Autor:
Santosh G. Valeja, Albert J. Chen, Wenxuan Cai, Denise J. Schwahn, Ying Peng, Timothy A. Hacker, Zachery R. Gregorich, Ying Ge, Xiaowen Liu, Huseyin Guner, Yi-Chen Chen, Han Zhang
Publikováno v:
Molecular & Cellular Proteomics : MCP
Heart failure (HF) is a leading cause of morbidity and mortality worldwide and is most often precipitated by myocardial infarction. However, the molecular changes driving cardiac dysfunction immediately after myocardial infarction remain poorly under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b97cac0559217bf9575843c5556b33
https://doi.org/10.1074/mcp.m114.040675
https://doi.org/10.1074/mcp.m114.040675
Publikováno v:
Analytical Chemistry
One of the challenges in proteomics is the proteome’s complexity, which necessitates the fractionation of proteins prior to the mass spectrometry (MS) analysis. Despite recent advances in top-down proteomics, separation of intact proteins remains c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693db017d60b5861beb825066de22d33
https://doi.org/10.1021/ac501836k
https://doi.org/10.1021/ac501836k
Publikováno v:
Journal of the American Society for Mass Spectrometry. 24:1722-1726
Fourier transform mass spectrometry (FTMS) of the isolated isotopic distribution for a highly charged biomolecule produces time-domain signal containing large amplitude signal "beats" separated by extended periods of much lower signal magnitude. Sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4ebdb6bd81be50fe7fc1c7461ae4b1
https://doi.org/10.1007/s13361-013-0735-5
https://doi.org/10.1007/s13361-013-0735-5
Publikováno v:
Analytical Chemistry. 85:4239-4246
Top-down electron capture dissociation (ECD) Fourier transform ion cyclotron resonance (FTICR) mass spectrometry was performed for structural analysis of an intact monoclonal antibody (IgG1kappa (κ) isotype, ~148 kDa). Simultaneous ECD for all charg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021370588ea4fabcd7b05c0d52d44f9d
https://doi.org/10.1021/ac303525n
https://doi.org/10.1021/ac303525n
Autor:
Santosh G. Valeja, Christopher L. Hendrickson, Nathan K. Kaiser, Alan G. Marshall, Jason C. Rouse, Feng Xian
Publikováno v:
Analytical Chemistry. 83:8391-8395
Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS) provides the highest mass resolving power and mass measurement accuracy for unambiguous identification of biomolecules. Previously, the highest-mass protein for which FTICR unit m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41df7a4ee4110287b7d5a8fc59034ccf
https://doi.org/10.1021/ac202429c
https://doi.org/10.1021/ac202429c
Autor:
Zachery R. Gregorich, Song Jin, Wenxuan Cai, Serife Ayaz-Guner, Ying Ge, Leekyoung Hwang, Santosh G. Valeja
Analysis of protein phosphorylation remains a significant challenge due to the low abundance of phosphoproteins and the low stoichiometry of phosphorylation, which requires effective enrichment of phosphoproteins. Here we have developed superparamagn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2185322fc54e076fc34328b76205764
https://europepmc.org/articles/PMC4372338/
https://europepmc.org/articles/PMC4372338/
Hydrogen/deuterium exchange monitored by mass spectrometry is an important non-perturbing tool to study protein structure and protein–protein interactions. However, water in the reversed-phase liquid chromatography mobile phase leads to back-exchan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c8387e3acc3fa3cd9641bf2ef823ff7
https://europepmc.org/articles/PMC3835171/
https://europepmc.org/articles/PMC3835171/