Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Santosh, Panjikar"'
Autor:
Shankar Raj Devkota, Pramod Aryal, Rina Pokhrel, Wanting Jiao, Andrew Perry, Santosh Panjikar, Richard J. Payne, Matthew C. J. Wilce, Ram Prasad Bhusal, Martin J. Stone
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Chemokines are key regulators of leukocyte trafficking and attractive targets for anti-inflammatory therapy. Evasins are chemokine-binding proteins from tick saliva, whose application as anti-inflammatory therapeutics will require manipulati
Externí odkaz:
https://doaj.org/article/26d075917c864d76b00e85e35012b9b0
Autor:
Emily R. R. Mackie, Andrew S. Barrow, Marie-Claire Giel, Mark D. Hulett, Anthony R. Gendall, Santosh Panjikar, Tatiana P. Soares da Costa
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Herbicide resistance represents one of the biggest threats to our natural environment and agricultural sector. Thus, new herbicides are urgently needed to tackle the rise in herbicide-resistant weeds. Here, we employed a novel strategy to re
Externí odkaz:
https://doaj.org/article/eceeb3445de3486eb8e9a93af8083536
Autor:
Lilian Hor, Akila Pilapitiya, James A. McKenna, Santosh Panjikar, Marilyn A. Anderson, Mickaël Desvaux, Jason J. Paxman, Begoña Heras
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Autotransporters are bacterial proteins that possess multiple activities associated with pathogenesis. Here the authors present the structure of the autotransporter subtilase Ssp from Serratia marcescens and show that its distinctive structural featu
Externí odkaz:
https://doaj.org/article/92aa96900898463092e56bee5126bdf0
Autor:
Yichen Zhong, Hakimeh Moghaddas Sani, Bishnu P. Paudel, Jason K. K. Low, Ana P. G. Silva, Stefan Mueller, Chandrika Deshpande, Santosh Panjikar, Xavier J. Reid, Max J. Bedward, Antoine M. van Oijen, Joel P. Mackay
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
CHD4 is an essential chromatin remodelling enzyme in complex organisms. Here the authors demonstrate that CHD4 activity is regulated both positively and negatively by distinct auxiliary domains, revealing parallels with other chromatin remodellers.
Externí odkaz:
https://doaj.org/article/344de9654b7241baa0c94cef93c12913
Autor:
Christopher R. Horne, Hariprasad Venugopal, Santosh Panjikar, David M. Wood, Amy Henrickson, Emre Brookes, Rachel A. North, James M. Murphy, Rosmarie Friemann, Michael D. W. Griffin, Georg Ramm, Borries Demeler, Renwick C. J. Dobson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The GntR superfamily is one of the largest families of transcription factors in prokaryotes. Here the authors combine biophysical analysis and structural biology to dissect the mechanism by which NanR — a GntR-family regulator — binds to its prom
Externí odkaz:
https://doaj.org/article/fbbaf67cd57e43b9861716dfe16d3c75
Autor:
Tatiana P Soares da Costa, Cody J Hall, Santosh Panjikar, Jessica A Wyllie, Rebecca M Christoff, Saadi Bayat, Mark D Hulett, Belinda M Abbott, Anthony R Gendall, Matthew A Perugini
Publikováno v:
eLife, Vol 10 (2021)
Weeds are becoming increasingly resistant to our current herbicides, posing a significant threat to agricultural production. Therefore, new herbicides with novel modes of action are urgently needed. In this study, we exploited a novel herbicide targe
Externí odkaz:
https://doaj.org/article/4a54238d54044027a2091d81d099209c
Autor:
Stuart Mills, Jun Aishima, David Aragao, Tom Tudor Caradoc-Davies, Nathan Cowieson, Christine L. Gee, Daniel Ericsson, Stephen Harrop, Santosh Panjikar, Kate Mary Louise Smith, Alan Riboldi-Tunnicliffe, Rachel Williamson, Jason Roy Price
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 76, Iss 7, Pp 1136-1138 (2020)
Exceptionally large crystals of posnjakite, Cu4SO4(OH)6(H2O), formed during corrosion of a Swagelock(tm) Snubber copper gasket within the MX1 beamline at the ANSTO-Melbourne, Australian Synchrotron. The crystal structure was solved using synchrotron
Externí odkaz:
https://doaj.org/article/98564edfb3384f13a1180d2fc949e5bc
Autor:
Jason J. Paxman, Alvin W. Lo, Matthew J. Sullivan, Santosh Panjikar, Michael Kuiper, Andrew E. Whitten, Geqing Wang, Chi-Hao Luan, Danilo G. Moriel, Lendl Tan, Kate M. Peters, Minh-Duy Phan, Christine L. Gee, Glen C. Ulett, Mark A. Schembri, Begoña Heras
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Autotransporter proteins are localised to the bacterial surface and promote colonisation of host epithelial surfaces. Here, the authors present the crystal structure of autotransporter UpaB and show evidence for distinct binding sites for glycosamino
Externí odkaz:
https://doaj.org/article/84181b0a975c40f082db3fb0320d1436
Publikováno v:
Journal of Structural Biology: X, Vol 4, Iss , Pp 100018- (2020)
Thiolases are a well characterized family of enzymes with two distinct categories: degradative, β-ketoadipyl-CoA thiolases and biosynthetic, acetoacetyl-CoA thiolases. Both classes share an identical catalytic triad but catalyze reactions in opposit
Externí odkaz:
https://doaj.org/article/26bb96fe401b44d28d92e97b743372b4
Autor:
Daouda A. K. Traore, Jessica A. Wisniewski, Sarena F. Flanigan, Paul J. Conroy, Santosh Panjikar, Yee-Foong Mok, Carmen Lao, Michael D. W. Griffin, Vicki Adams, Julian I. Rood, James C. Whisstock
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Conjugative transfer of antibiotic resistance plasmid pCW3 in Clostridium perfringens is mediated by the tcp locus. Here, the authors identify a wHTH-type protein, TcpK, that is essential for efficient plasmid transfer and interacts with the plasmid
Externí odkaz:
https://doaj.org/article/7cda5168800047dcbc57499355c58da2