C9ORF72 patient-derived endothelial cells drive blood-brain barrier disruption and contribute to neurotoxicity.

Autor: Aragón-González, Ana, Shaw, Allan C, Kok, Jannigje R, Roussel, Florence S, Santos Souza, Cleide dos, Granger, Sarah M, Vetter, Tatyana, de Diego, Yolanda, Meyer, Kathrin C, Beal, Selina N, Shaw, Pamela J, Ferraiuolo, Laura

Publikováno v: Fluids & Barriers of the CNS; 4/11/2024, Vol. 21 Issue 1, p1-14, 14p

Amyloid binding and beyond: a new approach for Alzheimer's disease drug discovery targeting Aβo-PrP ^C binding and downstream pathways.

Autor: Grayson JD; Department of Chemistry, University of Sheffield Brookhill Sheffield S3 7HF UK b.chen@sheffield.ac.uk., Baumgartner MP; Computational Chemistry and Cheminformatics, Eli Lilly and Company, Lilly Biotechnology Center San Diego CA 92121 USA., Santos Souza CD; Department of Chemistry, University of Sheffield Brookhill Sheffield S3 7HF UK b.chen@sheffield.ac.uk., Dawes SJ; Department of Chemistry, University of Sheffield Brookhill Sheffield S3 7HF UK b.chen@sheffield.ac.uk.; Faculty of Biological Sciences, University of Leeds Leeds LS2 9JT UK., El Idrissi IG; Univ Bari, Biofordrug Via Edoardo Orabona 4 I-70125 Bari Italy., Louth JC; Department of Chemistry, University of Sheffield Brookhill Sheffield S3 7HF UK b.chen@sheffield.ac.uk., Stimpson S; Department of Chemistry, University of Sheffield Brookhill Sheffield S3 7HF UK b.chen@sheffield.ac.uk., Mead E; Computational Chemistry and Chemoinformatics, Eli Lilly and Company Erl Wood Windlesham GU20 6PH UK., Dunbar C; Computational Chemistry and Chemoinformatics, Eli Lilly and Company Erl Wood Windlesham GU20 6PH UK., Wolak J; Computational Chemistry and Chemoinformatics, Eli Lilly and Company Erl Wood Windlesham GU20 6PH UK., Sharman G; Computational Chemistry and Chemoinformatics, Eli Lilly and Company Erl Wood Windlesham GU20 6PH UK., Evans D; Computational Chemistry and Chemoinformatics, Eli Lilly and Company Erl Wood Windlesham GU20 6PH UK., Zhuravleva A; Faculty of Biological Sciences, University of Leeds Leeds LS2 9JT UK., Roldan MS; Sheffield Institute of Translational Neuroscience, University of Sheffield Sheffield S10 2HQ UK., Colabufo NA; Univ Bari, Biofordrug Via Edoardo Orabona 4 I-70125 Bari Italy.; Univ Bari, Dipartimento Farm Sci Farmaco Via Edoardo Orabona 4 I-70125 Bari Italy., Ning K; Sheffield Institute of Translational Neuroscience, University of Sheffield Sheffield S10 2HQ UK., Garwood C; Sheffield Institute of Translational Neuroscience, University of Sheffield Sheffield S10 2HQ UK., Thomas JA; Department of Chemistry, University of Sheffield Brookhill Sheffield S3 7HF UK b.chen@sheffield.ac.uk., Partridge BM; Department of Chemistry, University of Sheffield Brookhill Sheffield S3 7HF UK b.chen@sheffield.ac.uk., de la Vega de Leon A; Information School, University of Sheffield Sheffield S1 4DP UK., Gillet VJ; Information School, University of Sheffield Sheffield S1 4DP UK., Rauter AP; Centro de Química Estrutural, Faculdade de Ciências, Universidade de Lisboa ED C8, 5 piso 1749-016 Lisboa Portugal., Chen B; Department of Chemistry, University of Sheffield Brookhill Sheffield S3 7HF UK b.chen@sheffield.ac.uk.

Publikováno v: Chemical science [Chem Sci] 2021 Feb 01; Vol. 12 (10), pp. 3768-3785. Date of Electronic Publication: 2021 Feb 01.