Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Santos Mañes"'
Autor:
Miguel Quintela-Fandino, Esther Holgado, Luis Manso, Serafin Morales, Begoña Bermejo, Ramon Colomer, Juan V. Apala, Raquel Blanco, Manuel Muñoz, Eduardo Caleiras, Vega Iranzo, Mario Martinez, Orlando Dominguez, Javier Hornedo, Lucia Gonzalez-Cortijo, Javier Cortes, Ariadna Gasol Cudos, Diego Malon, Antonio Lopez-Alonso, María C. Moreno-Ortíz, Silvana Mouron, Santos Mañes
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-14 (2020)
Abstract Background Preclinical research suggests that the efficacy of immune checkpoint inhibitors in breast cancer can be enhanced by combining them with antiangiogenics, particularly in a sequential fashion. We sought to explore the efficacy and b
Externí odkaz:
https://doaj.org/article/3f6add655fbe4b0d92de37dd9a97fca3
Autor:
Itziar de Rojas, Laura del Barrio, Isabel Hernández, Laura Montrreal, Pablo García-González, Marta Marquié, Sergi Valero, Amanda Cano, Adelina Orellana, Mercè Boada, Santos Mañes, Agustín Ruiz
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2186 (2023)
Cholesterol efflux capacity (CEC) is of interest given its potential relationship with several important clinical conditions including Alzheimer’s disease. The inactivation of the APOE locus in mouse models supports the idea that it is involved in
Externí odkaz:
https://doaj.org/article/895d5ebd14004532a9af7d2dfedea882
Autor:
Raquel Blanco, Marta Gómez de Cedrón, Laura Gámez-Reche, Ana Martín-Leal, Alicia González-Martín, Rosa A. Lacalle, Ana Ramírez de Molina, Santos Mañes
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The inhibition of anabolic pathways, such as aerobic glycolysis, is a metabolic cornerstone of memory T cell differentiation and function. However, the signals that hamper these anabolic pathways are not completely known. Recent evidence pinpoints th
Externí odkaz:
https://doaj.org/article/4a7a443f0b85408e85ccd4c12c7a480f
Autor:
Jesús Ogando, María Eugenia Sáez, Javier Santos, Cristina Nuevo-Tapioles, Marta Gut, Anna Esteve-Codina, Simon Heath, Antonio González-Pérez, José M. Cuezva, Rosa Ana Lacalle, Santos Mañes
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-17 (2019)
Abstract Background Binding of the programmed death-1 (PD-1) receptor to its ligands (PD-L1/2) transduces inhibitory signals that promote exhaustion of activated T cells. Blockade of the PD-1 pathway is widely used for cancer treatment, yet the inhib
Externí odkaz:
https://doaj.org/article/bf07bf307d7e439992d5b6c5761a4ede
Autor:
Ruth Conde-Garrosa, David Sancho, Santos Mañes, Alfonso R Sanchez-Paulete, Francisco J Cueto, Carlos del Fresno, Paola Brandi, Alexis J. Combes, Elena Hernández-García, Michel Enamorado, Christian P Bromley, Manuel J Gomez, Santiago Zelenay, Salvador Iborra, Matthew F. Krummel
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
Background Conventional type 1 dendritic cells (cDC1s) are central to antitumor immunity and their presence in the tumor microenvironment associates with improved outcomes in patients with cancer. DNGR-1 (CLEC9A) is a dead cell-sensing receptor highl
Externí odkaz:
https://doaj.org/article/7174fcff49ec4c968e5c2cd9447b8742
Autor:
Diego Martínez-Rey, Lorena Carmona-Rodríguez, María Jesús Fernández-Aceñero, Emilia Mira, Santos Mañes
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Tumor-infiltrating lymphocytes (TILs) are major players in the immune-mediated control of cancer and the response to immunotherapy. In primary cancers, however, TILs are commonly absent, suggesting T-cell entry into the tumor microenvironment (TME) t
Externí odkaz:
https://doaj.org/article/b417d188debd41f3bf1f0a3b9c958dda
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
The conversion of a non-T cell-inflamed into a T cell-inflamed tumor microenvironment (TME) is a key to sensitizing tumors to T-cell-based immunotherapies. Recent data show that the extracellular superoxide dismutase (SOD3) alters endothelial basemen
Externí odkaz:
https://doaj.org/article/6af5ba402178497190ef81a105c90eb7
Autor:
Emilia Mira, Lorena Carmona-Rodríguez, Beatriz Pérez-Villamil, Josefina Casas, María Jesús Fernández-Aceñero, Diego Martínez-Rey, Paula Martín-González, Ignacio Heras-Murillo, Mateo Paz-Cabezas, Manuel Tardáguila, Tim D. Oury, Silvia Martín-Puig, Rosa Ana Lacalle, Gemma Fabriás, Eduardo Díaz-Rubio, Santos Mañes
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Tumour vasculature influences drug delivery. Here, the authors show that SOD3 re-expression enhances doxorubicin delivery and effects through normalization of tumour vasculature via the HIF-2a/VE-cadherin pathway.
Externí odkaz:
https://doaj.org/article/a5a223591ab94254855b6f9c6cd6f2c6
Autor:
Ezequiel Monferrer, Sabina Sanegre, Isaac Vieco-Martí, Amparo López-Carrasco, Fernando Fariñas, Antonio Villatoro, Sergio Abanades, Santos Mañes, Luis de la Cruz-Merino, Rosa Noguera, Tomás Álvaro Naranjo
Publikováno v:
Biomedicines, Vol 9, Iss 7, p 798 (2021)
The study of cancer biology should be based around a comprehensive vision of the entire tumor ecosystem, considering the functional, bioenergetic and metabolic state of tumor cells and those of their microenvironment, and placing particular importanc
Externí odkaz:
https://doaj.org/article/2991c90533d0489cbf6caaa4b80b9c6c
Autor:
Diego Herrero, Susana Cañón, Guillermo Albericio, Rosa María Carmona, Susana Aguilar, Santos Mañes, Antonio Bernad
Publikováno v:
Redox Biology, Vol 22, Iss , Pp - (2019)
Adult progenitor cells reside in specialized microenvironments which maintain their undifferentiated cell state and trigger regenerative responses following injury. Although these environments are well described in several tissues, the cellular compo
Externí odkaz:
https://doaj.org/article/a743bac970e6403bb51a524ea98c9fd5