Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Santos J. Franco"'
Publikováno v:
eLife, Vol 11 (2022)
Heterozygous, missense mutations in α- or β-tubulin genes are associated with a wide range of human brain malformations, known as tubulinopathies. We seek to understand whether a mutation’s impact at the molecular and cellular levels scale with t
Externí odkaz:
https://doaj.org/article/8211b609b1274c8a87b301f2eff5db52
Autor:
Mason S. Kleinjan, William C. Buchta, Roberto Ogelman, In-Wook Hwang, Masaaki Kuwajima, Dusten D. Hubbard, Dean J. Kareemo, Olga Prikhodko, Samantha L. Olah, Luis E. Gomez Wulschner, Wickliffe C. Abraham, Santos J. Franco, Kristen M. Harris, Won Chan Oh, Matthew J. Kennedy
Publikováno v:
Neuron.
Dendritic spines can be directly connected to both inhibitory and excitatory presynaptic terminals, resulting in nanometer-scale proximity of opposing synaptic functions. While dually innervated spines (DiSs) are observed throughout the central nervo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c5d725400726014039305b422db11e
https://pubmed.ncbi.nlm.nih.gov/36395772
https://pubmed.ncbi.nlm.nih.gov/36395772
Heterozygous, missense mutations in α- or β-tubulin genes are associated with a wide range of human brain malformations, known as tubulinopathies. We seek to understand whether a mutation’s impact at the molecular and cellular levels scale with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dca25a1a7c0141f2c2eb0666e8a9f2c
https://doi.org/10.1101/2021.12.06.471490
https://doi.org/10.1101/2021.12.06.471490
In the developing nervous system, progenitors first generate neurons before making astrocytes and oligodendrocytes. We previously showed that increased Sonic hedgehog (Shh) signaling in dorsal forebrain progenitors is important for their production o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7266498dff27f52f2b1a7778027aafe3
https://doi.org/10.1101/2020.10.18.344515
https://doi.org/10.1101/2020.10.18.344515
Reelin is a glycoprotein secreted by Cajal-Retzius cells to regulate development of the cerebral cortex. Reelin binding to its receptors on immature neurons initiates a signaling cascade through the downstream adaptor protein, Dab1. Defects in this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69519a1b626878aee2a1adc6b48aa12c
https://doi.org/10.1101/2020.01.30.925537
https://doi.org/10.1101/2020.01.30.925537
Autor:
Samuel J. Pleasure, Brett E Dwyer, Santiago P. Fregoso, Odessa Yabut, Hector G. Gomez, Santos J. Franco, Caitlin C. Winkler
Publikováno v:
The Journal of Neuroscience. 38:5237-5250
Neural progenitor cells in the developing dorsal forebrain give rise to excitatory neurons, astrocytes, and oligodendrocytes for the neocortex. While we are starting to gain a better understanding about the mechanisms that direct the formation of neo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afff81857cfa231f089e5d50f27c082
https://doi.org/10.1523/jneurosci.3392-17.2018
https://doi.org/10.1523/jneurosci.3392-17.2018
Autor:
Caitlin C. Winkler, Santos J. Franco
Publikováno v:
Dev Biol
The majority of oligodendrocytes in the neocortex originate from neural progenitors that reside in the dorsal forebrain. We recently showed that Sonic Hedgehog (Shh) signaling in these dorsal progenitors is required to produce normal numbers of neoco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd1e6f9d06856d9402a5021e8fdbee92
https://doi.org/10.1101/547968
https://doi.org/10.1101/547968
Lmx1a drives Cux2 expression in the cortical hem through activation of a conserved intronic enhancer
Publikováno v:
Development.
During neocortical development, neurons are produced by a diverse pool of neural progenitors. A subset of progenitors express the Cux2 gene and are fate-restricted to produce certain neuronal subtypes, but the upstream pathways that specify these pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35097513a7aec79be20bf3a89deafe8f
https://doi.org/10.1242/dev.170068
https://doi.org/10.1242/dev.170068
Publikováno v:
eNeuro
Mutations and copy number variants of the CUB and Sushi multiple domains 2 (CSMD2) gene are associated with neuropsychiatric disease.CSMD2encodes a single-pass transmembrane protein with a large extracellular domain comprising repeats of CUB and Sush
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03029af473b001f66d5f3dea03d3cf99
https://pubmed.ncbi.nlm.nih.gov/31068362
https://pubmed.ncbi.nlm.nih.gov/31068362