Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats

Autor: D'Amore, V., Santolini, I., Celli, R., Lionetto, L., De Fusco, A., Simmaco, M., van Rijn, C.M., Vieira, E., Stauffer, S.R., Conn, P.J., Bosco, P., Nicoletti, F., van Luijtelaar, G., Ngomba, R.T.

Publikováno v: In Neuropharmacology October 2014 85:91-103

Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy

Autor: Ngomba, R.T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., van Rijn, C.M., D’Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., van Luijtelaar, G., Nicoletti, F.

Publikováno v: In Neuropharmacology 2011 60(7):1281-1291

Is there a future for mGlu5-positive allosteric modulators in absence epilepsy? A comparison with ethosuximide

Autor: Luijtelaar, E.L.J.M. van, D'Amore, V., Santolini, I., Ngomba, R.T., Giovanni, G. di, Battaglia, G., Nicoletti, F.

Publikováno v: The Receptors (REC) ; 31, 207-224. Cham : Springer
STARTPAGE=207;ENDPAGE=224;TITLE=The Receptors (REC) ; 31
Ngomba, R.T.; Giovanni, G. di; Battaglia, G. (ed.), mGLU Receptors, pp. 207-224
mGLU Receptors ISBN: 9783319561684

Contains fulltext : 175798.pdf (Publisher’s version ) (Open Access) Ethosuximide is the drug of choice in the treatment of various types of absence seizures. However, there is plenty of room for other anti-absence drugs, considering that not all su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b7f3a6c38d1e0b9cf03046ab2f8204
https://hdl.handle.net/2066/175798

WAG/Rij rats show a reduced expression of CB₁ receptors in thalamic nuclei and respond to the CB₁ receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges

Autor: van Rijn, C. M., Gaetani, Silvana, Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, Vincenzo, van Luijtelaar, G., Nicoletti, Ferdinando, Ngomba, R. T.

Publikováno v: Epilepsia. 51(8)

Genetically epileptic WAG/Rij rats develop spontaneous absence-like seizures after 3 months of age. We used WAG/Rij rats to examine whether absence seizures are associated with changes in the expression of type-1 cannabinoid (CB₁) receptors.Recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fb94fccc128785b420b5385e3dfb01ea
https://pubmed.ncbi.nlm.nih.gov/20132294

WAG/Rij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges

Autor: Rijn, C.M. van, Gaetani, S., Santolini, I., Badura, A., Fu, J., Watanabe, M., Cuomo, V., Luijtelaar, E.L.J.M. van, Nicoletti, F., Ngomba, R.T.

Publikováno v: Epilepsia, 51, 1511-1521
Epilepsia, 51, 8, pp. 1511-1521

Contains fulltext : 90547.pdf (Publisher’s version ) (Closed access) Purpose: Genetically epileptic WAG/Rij rats develop spontaneous absence-like seizures after 3 months of age. We used WAG/Rij rats to examine whether absence seizures are associate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fdb450304cbc9cfbdaca1f1457186345
http://hdl.handle.net/2066/90547