Zobrazeno 1 - 10
of 234
pro vyhledávání: '"Santo Landolfo"'
Autor:
Stefano Raviola, Gloria Griffante, Andrea Iannucci, Shikha Chandel, Irene Lo Cigno, Davide Lacarbonara, Valeria Caneparo, Selina Pasquero, Francesco Favero, Davide Corà, Elena Trisolini, Renzo Boldorini, Vincenzo Cantaluppi, Santo Landolfo, Marisa Gariglio, Marco De Andrea
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-19 (2024)
Abstract Human cytomegalovirus (HCMV) is an opportunistic pathogen causing severe diseases in immunosuppressed individuals. To replicate its double-stranded DNA genome, HCMV induces profound changes in cellular homeostasis that may resemble senescenc
Externí odkaz:
https://doaj.org/article/49b1d023c83d4f13a8eef96deee1aebf
Autor:
Camilla Albano, Matteo Biolatti, Jasenka Mazibrada, Selina Pasquero, Francesca Gugliesi, Irene Lo Cigno, Federica Calati, Greta Bajetto, Giuseppe Riva, Gloria Griffante, Santo Landolfo, Marisa Gariglio, Marco De Andrea, Valentina Dell’Oste
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Citrullination is an emerging post-translational modification catalyzed by peptidyl-arginine deiminases (PADs) that convert peptidyl-arginine into peptidyl-citrulline. In humans, the PAD family consists of five isozymes (PADs 1-4, 6) involved in mult
Externí odkaz:
https://doaj.org/article/42f075546eb64640a5dc70ecfc043410
Autor:
Selina Pasquero, Francesca Gugliesi, Matteo Biolatti, Valentina Dell'Oste, Camilla Albano, Greta Bajetto, Gloria Griffante, Linda Trifirò, Bianca Brugo, Stefano Raviola, Davide Lacarbonara, Qiao Yang, Sen Sudeshna, Leonard Barasa, Hafeez Haniff, Paul R Thompson, Santo Landolfo, Marco De Andrea
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011849 (2023)
Herpes simplex virus 1 (HSV-1) is a neurotropic virus that remains latent in neuronal cell bodies but reactivates throughout an individual's life, causing severe adverse reactions, such as herpes simplex encephalitis (HSE). Recently, it has also been
Externí odkaz:
https://doaj.org/article/9ab133fae77743a9b39e0c3aef5aae35
Autor:
Gloria Griffante, Francesca Gugliesi, Selina Pasquero, Valentina Dell’Oste, Matteo Biolatti, Ari J. Salinger, Santanu Mondal, Paul R. Thompson, Eranthie Weerapana, Robert J. Lebbink, Jasper A. Soppe, Thomas Stamminger, Virginie Girault, Andreas Pichlmair, Gábor Oroszlán, Donald M. Coen, Marco De Andrea, Santo Landolfo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Citrullination is a posttranslational modification of arginines. Here, the authors show that HCMV infection increases citrullination of host and virus proteins to promote infection and that citrullinated interferon-inducible protein IFIT1 is impaired
Externí odkaz:
https://doaj.org/article/d9f89f1cfaed42dc92c156e171d58d7e
Autor:
Gloria Griffante, Weronika Hewelt-Belka, Camilla Albano, Francesca Gugliesi, Selina Pasquero, Sergio Fernando Castillo Pacheco, Greta Bajetto, Paolo Ettore Porporato, Erica Mina, Marta Vallino, Christian Krapp, Martin Roelsgaard Jakobsen, John Purdy, Jens von Einem, Santo Landolfo, Valentina Dell’Oste, Matteo Biolatti
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Cellular lipid metabolism plays a pivotal role in human cytomegalovirus (HCMV) infection, as increased lipogenesis in HCMV-infected cells favors the envelopment of newly synthesized viral particles. As all cells are equipped with restriction
Externí odkaz:
https://doaj.org/article/b40fe9f446da4f5a9789a39792830e92
Autor:
Ganna Galitska, Alessandra Coscia, Diego Forni, Lars Steinbrueck, Simone De Meo, Matteo Biolatti, Marco De Andrea, Rachele Cagliani, Agata Leone, Enrico Bertino, Thomas Schulz, Angela Santoni, Santo Landolfo, Manuela Sironi, Cristina Cerboni, Valentina Dell’Oste
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Human cytomegalovirus (HCMV) infection often leads to systemic disease in immunodeficient patients and congenitally infected children. Despite its clinical significance, the exact mechanisms contributing to HCMV pathogenesis and clinical outcomes hav
Externí odkaz:
https://doaj.org/article/78f4b8017276476cb11dc335eb2a17b4
Autor:
Andrea Iannucci, Valeria Caneparo, Stefano Raviola, Isacco Debernardi, Donato Colangelo, Riccardo Miggiano, Gloria Griffante, Santo Landolfo, Marisa Gariglio, Marco De Andrea
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008811 (2020)
Damage-associated molecular patterns (DAMPs) are endogenous molecules activating the immune system upon release from injured cells. Here we show that the IFI16 protein, once freely released in the extracellular milieu of chronically inflamed tissues,
Externí odkaz:
https://doaj.org/article/2da90dc35e4a4ff49a931036a2cb8a8b
Autor:
Simone De Meo, Valentina Dell'Oste, Rosa Molfetta, Valentina Tassinari, Lavinia Vittoria Lotti, Simone Vespa, Benedetta Pignoloni, Daniela Angela Covino, Laura Fantuzzi, Roberta Bona, Alessandra Zingoni, Ilaria Nardone, Matteo Biolatti, Alessandra Coscia, Rossella Paolini, Monsef Benkirane, Fredrik Edfors, Tatyana Sandalova, Adnane Achour, John Hiscott, Santo Landolfo, Angela Santoni, Cristina Cerboni
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008855 (2020)
SAMHD1 is a host restriction factor that functions to restrict both retroviruses and DNA viruses, based on its nuclear deoxynucleotide triphosphate (dNTP) hydrolase activity that limits availability of intracellular dNTP pools. In the present study,
Externí odkaz:
https://doaj.org/article/f761f66d2d31441aba50004cfa6438dd
Autor:
Alessandra Mozzi, Matteo Biolatti, Rachele Cagliani, Diego Forni, Valentina Dell'Oste, Chiara Pontremoli, Chiara Vantaggiato, Uberto Pozzoli, Mario Clerici, Santo Landolfo, Manuela Sironi
Publikováno v:
PLoS Pathogens, Vol 16, Iss 5, p e1008476 (2020)
Cytomegaloviruses (order Herpesvirales) display remarkable species-specificity as a result of long-term co-evolution with their mammalian hosts. Human cytomegalovirus (HCMV) is exquisitely adapted to our species and displays high genetic diversity. W
Externí odkaz:
https://doaj.org/article/b71be8ab30674148b7b21ed9396b1bb4
Autor:
Pier Paolo Piccaluga, Mohsen Navari, Axel Visani, Flavia Rigotti, Claudio Agostinelli, Simona Righi, Erica Diani, Marco Ligozzi, Maria Carelli, Cristina Ponti, Isabella Bon, Donato Zipeto, Santo Landolfo, Davide Gibellini
Publikováno v:
Heliyon, Vol 5, Iss 11, Pp e02643- (2019)
IFI16, member of the IFN-inducible PYHIN-200 gene family, modulates proliferation, survival and differentiation of different cell lineages. In particular, IFI16 expression, which is regulated during the differentiation of B cells, was recently studie
Externí odkaz:
https://doaj.org/article/2446df23ffcd4e33aa2269d21bf57689