Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor.

Autor: Alex N Bullock, Santina Russo, Ann Amos, Nicholas Pagano, Howard Bregman, Judit E Debreczeni, Wen Hwa Lee, Frank von Delft, Eric Meggers, Stefan Knapp

Publikováno v: PLoS ONE, Vol 4, Iss 10, p e7112 (2009)

The serine/threonine kinase PIM2 is highly expressed in human leukemia and lymphomas and has been shown to positively regulate survival and proliferation of tumor cells. Its diverse ATP site makes PIM2 a promising target for the development of antica

Externí odkaz: https://doaj.org/article/0e3b4f4d179f4f3d8adb5dd5bd271108

Der schwierige Weg zu sich selbst

Autor: Santina Russo

Publikováno v: Schweizerische Ärztezeitung.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e872b9de1b737a00740301cb1601a08e
https://doi.org/10.4414/saez.2023.21421

Les femmes au bloc

Autor: Santina Russo

Publikováno v: Bulletin des Médecins Suisses.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d96221144b146e51094a1ddc192b1c3
https://doi.org/10.4414/bms.2023.21368

Metzincin's canonical methionine is responsible for the structural integrity of the zinc-binding site

Autor: Mario Bumann, Anselm Erich Oberholzer, Ulrich Baumann, Thomas Hege, Santina Russo

Publikováno v: Oberholzer, Anselm E.; Bumann, Mario; Hege, Thomas; Russo, Santina; Baumann, Ulrich (2009). Metzincin's canonical methionine is responsible for the structural integrity of the zinc-binding site. Biological chemistry, 390(9), pp. 875-881. Berlin: Walter de Gruyter 10.1515/BC.2009.100

The metzincins constitute a subclan of metalloproteases possessing a HEXXHXXGXXH/D zinc-binding consensus sequence where the three histidines are zinc ligands and the glutamic acid is the catalytic base. A completely conserved methionine is located d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de4ad9e2d587e6301395886fa8eead7
https://pubmed.ncbi.nlm.nih.gov/19558324

Crystal structure and function of the zinc uptake regulator FurB from Mycobacterium tuberculosis

Autor: Anna Milano, Debora Lucarelli, Elspeth F. Garman, Ehmke Pohl, Santina Russo, Wolfram Meyer-Klaucke

Publikováno v: The Journal of biological chemistry. 282(13)

Members of the ferric/zinc uptake regulator (Fur/Zur) family are the central metal-dependent regulator proteins in many Gram-negative and -positive bacteria. They are responsible for the control of a wide variety of basic physiological processes and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9843e51aa7ce626e7bca48c2372f695
https://pubmed.ncbi.nlm.nih.gov/17213192