Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Santiago Zelenay"'
Autor:
Charlotte R. Bell, Victoria S. Pelly, Agrin Moeini, Shih-Chieh Chiang, Eimear Flanagan, Christian P. Bromley, Christopher Clark, Charles H. Earnshaw, Maria A. Koufaki, Eduardo Bonavita, Santiago Zelenay
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
COX-2-mediated prostaglandin E2 (PGE2) release from dying cancer cells contributes to cytotoxic therapy resistance. Here the authors show that cytotoxic drugs induce PGE2 release only in cancer cells with basal COX-2 activity and that pharmacological
Externí odkaz:
https://doaj.org/article/2367c05eefed45eabfb5cebec3bd1bde
Autor:
Charlotte R. Bell, Santiago Zelenay
Publikováno v:
Cell Stress, Vol 6, Iss 9, Pp 76-78 (2022)
Cytotoxic therapies, such as chemotherapy and radiotherapy, are mainstays of cancer treatment for both early and unresectable, advanced disease. In addition to debulking the tumour mass through direct killing of proliferating tumour cells, these trea
Externí odkaz:
https://doaj.org/article/2db4b708ade04497bfa798ddff451507
Autor:
Ruth Conde-Garrosa, David Sancho, Santos Mañes, Alfonso R Sanchez-Paulete, Francisco J Cueto, Carlos del Fresno, Paola Brandi, Alexis J. Combes, Elena Hernández-García, Michel Enamorado, Christian P Bromley, Manuel J Gomez, Santiago Zelenay, Salvador Iborra, Matthew F. Krummel
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
Background Conventional type 1 dendritic cells (cDC1s) are central to antitumor immunity and their presence in the tumor microenvironment associates with improved outcomes in patients with cancer. DNGR-1 (CLEC9A) is a dead cell-sensing receptor highl
Externí odkaz:
https://doaj.org/article/7174fcff49ec4c968e5c2cd9447b8742
Autor:
Santiago Zelenay, Daniela S. Thommen, Ton N. Schumacher, Claus Jørgensen, Shih-Chieh Chiang, Eimear Flanagan, Christian P. Bromley, Antonia Banyard, Adrian Blanco-Gomez, Colin Hutton, Charlotte R. Bell, Eduardo Bonavita, Lisanne M. Roelofsen, Agrin Moeini, Victoria S. Pelly
Table S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017a3c40264b8e2f69612f9eb8e7c603
https://doi.org/10.1158/2159-8290.22539473
https://doi.org/10.1158/2159-8290.22539473
Autor:
Santiago Zelenay, Daniela S. Thommen, Ton N. Schumacher, Claus Jørgensen, Shih-Chieh Chiang, Eimear Flanagan, Christian P. Bromley, Antonia Banyard, Adrian Blanco-Gomez, Colin Hutton, Charlotte R. Bell, Eduardo Bonavita, Lisanne M. Roelofsen, Agrin Moeini, Victoria S. Pelly
Identifying strategies to improve the efficacy of immune checkpoint blockade (ICB) remains a major clinical need. Here, we show that therapeutically targeting the COX2/PGE2/EP2-4 pathway with widely used nonsteroidal and steroidal anti-inflammatory d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8984675ccc2ee02aad006ca4186bf241
https://doi.org/10.1158/2159-8290.c.6549104.v1
https://doi.org/10.1158/2159-8290.c.6549104.v1
Autor:
Santiago Zelenay, Daniela S. Thommen, Ton N. Schumacher, Claus Jørgensen, Shih-Chieh Chiang, Eimear Flanagan, Christian P. Bromley, Antonia Banyard, Adrian Blanco-Gomez, Colin Hutton, Charlotte R. Bell, Eduardo Bonavita, Lisanne M. Roelofsen, Agrin Moeini, Victoria S. Pelly
Supplementary Figures and supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368b85f9b253cc646efd59ce772aa109
https://doi.org/10.1158/2159-8290.22539494.v1
https://doi.org/10.1158/2159-8290.22539494.v1
Autor:
Sophie Curio, Wanzun Lin, Christian Bromley, Jenny McGovern, Chiara Triulzi, Gustav Jonsson, Ghita Ghislat, Santiago Zelenay, Nadia Guerra
Publikováno v:
Cancers; Volume 15; Issue 6; Pages: 1792
Treating colorectal cancer (CRC) is a major challenge due to the heterogeneous immunological, clinical and pathological landscapes. Immunotherapy has so far only proven effective in a very limited subgroup of CRC patients. To better define the immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd3dcdee5b40b6866ec78f272cdba58
https://doi.org/10.3390/cancers15061792
https://doi.org/10.3390/cancers15061792
Autor:
Santiago Zelenay, Caetano Reis e Sousa, Felix Randow, Hefin Rhys, Neil C. Rogers, Hanna Blees, Oliver Schulz, Michael D. Buck, Cara J. Ellison, Conor M. Henry, Eleanor Childs, David C. Thomas, Venizelos Papayannopoulos, Johnathan Canton, Sebastian Amigorena, Andrés Alloatti, Lucy M. Collinson, Marie-Charlotte Domart
Publikováno v:
Nat Immunol
Nature Immunology
Nature Immunology, 2021, 22 (2), pp.140-153. ⟨10.1038/s41590-020-00824-x⟩
Nature Immunology
Nature Immunology, 2021, 22 (2), pp.140-153. ⟨10.1038/s41590-020-00824-x⟩
International audience; Type 1 conventional dendritic (cDC1) cells are necessary for cross-presentation of many viral and tumor antigens to CD8+ T cells. cDC1 cells can be identified in mice and humans by high expression of DNGR-1 (also known as CLEC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5096a9727f004540e3f878b16851a37
https://doi.org/10.1038/s41590-020-00824-x
https://doi.org/10.1038/s41590-020-00824-x
Autor:
Jorn E Stok, Timo Oosenbrug, Laurens R ter Haar, Dennis Gravekamp, Christian P Bromley, Santiago Zelenay, Caetano Reis e Sousa, Annemarthe G van der Veen
Publikováno v:
EMBO Journal, 41(6). WILEY
RNA editing by the adenosine deaminase ADAR1 prevents innate immune responses to endogenous RNAs. In ADAR1-deficient cells, unedited self RNAs form base-paired structures that resemble viral RNAs and inadvertently activate the cytosolic RIG-I-like re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717cd54e407206e491278854792a4930
https://pubmed.ncbi.nlm.nih.gov/35156720
https://pubmed.ncbi.nlm.nih.gov/35156720
Autor:
Dennis Gravekamp, Caetano Reis e Sousa, Timo Oosenbrug, Jorn E. Stok, Santiago Zelenay, Laurens R. ter Haar, Annemarthe G. van der Veen, Christian P. Bromley
RNA editing by the enzyme Adenosine Deaminase Acting on RNA 1 (ADAR1) is an important mechanism by which cells avoid innate immune responses to some endogenous RNAs. In ADAR1-deficient cells, unedited self RNAs can form base-paired structures that re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c9202a96659e296b966c3e9921763f6
https://doi.org/10.1101/2021.10.27.465188
https://doi.org/10.1101/2021.10.27.465188