Neutralizing S1P inhibits intratumoral hypoxia, induces vascular remodelling and sensitizes to chemotherapy in prostate cancer

Autor: Santiago Zalvidea, Guillaume Andrieu, Roger A. Sabbadini, Sylvain Richard, Olivier Cuvillier, Cécile Gstalder, Pierre Bouquerel, Isabelle Ader, Bernard Malavaud, Muriel Golzio

Publikováno v: Oncotarget
Oncotarget, Impact journals, 2015, 6 (15), ⟨10.18632/oncotarget.3144⟩
Scopus-Elsevier

Hypoxia promotes neovascularization, increased tumor growth, and therapeutic resistance. The transcription factor, hypoxia-inducible factor 1α (HIF-1α), has been reported as the master driver of adaptation to hypoxia. We previously identified the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7373c8dd964ec553b366e947876aa737
https://pubmed.ncbi.nlm.nih.gov/25915662

Carbon Monoxide Pollution Promotes Cardiac Remodeling and Ventricular Arrhythmia in Healthy Rats

Autor: Sylvain Richard, Cyril Reboul, Maurice Hayot, Lucas Andre, Romain Perrier, Julien Boissiere, Santiago Zalvidea, Stéphane Tanguy, Philippe Obert, Grégory Meyer, Olivier Cazorla, François Boucher, Jérôme Thireau, Patrice Bideaux

Publikováno v: American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2010, 181 (6), pp.587-595. ⟨10.1164/rccm.200905-0794OC⟩
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2010, 181 (6), pp.587-95. ⟨10.1164/rccm.200905-0794OC⟩

International audience; RATIONALE: Epidemiologic studies associate atmospheric carbon monoxide (CO) pollution with adverse cardiovascular outcomes and increased cardiac mortality risk. However, there is a lack of data regarding cellular mechanisms in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b97ea47c724e8d2a936bc09cecab7a8
https://hal.umontpellier.fr/hal-01824352/file/2010-AJRCCM-andre-2010-CO_HAL.pdf

High plasmatic angiotensin-converting enzyme (ACE) activity is not correlated with training-induced left ventricular growth in ACE congenic rats

Autor: Santiago Zalvidea, Karen Lambert, Bernard Jover, Michel Dauzat, G. Py, D. Le Gallais

Publikováno v: Acta Physiologica
Acta Physiologica, Wiley, 2008, 194 (2), pp.141-147. ⟨10.1111/j.1748-1716.2008.01868.x⟩

International audience; AIM: The aim of this study was to determine the influence of angiotensin-converting enzyme (ACE) genotype on left ventricular growth after endurance training, in ACE congenic rats with plasma ACE activity twice as high as the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79701526a85743f03e483c10e5240635
https://pubmed.ncbi.nlm.nih.gov/18811912

P39 - Altération précoce de la contractilité des cardiomyocytes lors du syndrome métabolique expérimental d’origine nutritionnelle. Effet préventif d’un extrait polyphénolique de vin rouge

Autor: Gérard Cros, Olivier Cazorla, Catherine Oiry, Lucas Andre, Richard Magous, Sylvain Richard, E. Le Scanf, Cécile Cassan, Pierre-Louis Teissedre, Santiago Zalvidea

Publikováno v: Diabetes & Metabolism. 37:A44

Introduction Nous avons montre que le syndrome metabolique (SM), induit experimentalement par une alimentation enrichie en fructose 60% (F), etait associe a une augmentation de la pression arterielle, une fibrose cardiaque et une hyperproduction d'es

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7fa1eff82e4616b204e8728903aec279
https://doi.org/10.1016/s1262-3636(11)70665-6

ACE inhibition prevents diastolic Ca2+ overload and loss of myofilament Ca2+ sensitivity after myocardial infarction. : Molecular effects of delapril on cardiomyocytes

Autor: Christophe Heymes, Lucas Andre, Ivar Sjaastad, Cécile Cassan, Franck Aimond, Sylvain Richard, Jean-Luc Pasquié, Yannis Sainte-Marie, Olivier Cazorla, Jérôme Thireau, Santiago Zalvidea, Xavier Loyer

Publikováno v: ResearcherID
Current Molecular Medicine
Current Molecular Medicine, Bentham Science Publishers, 2012, 12 (2), pp.206-17

International audience; Prevention of adverse cardiac remodeling after myocardial infarction (MI) remains a therapeutic challenge. Angiotensin-converting enzyme inhibitors (ACE-I) are a well-established first-line treatment. ACE-I delay fibrosis, but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303493c25a055722a20c24e26cc6623b
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000300638600010&KeyUID=WOS:000300638600010