Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Santiago Vilar"'
The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification
Autor:
Carrow I. Wells, Hassan Al-Ali, David M. Andrews, Christopher R. M. Asquith, Alison D. Axtman, Ivan Dikic, Daniel Ebner, Peter Ettmayer, Christian Fischer, Mathias Frederiksen, Robert E. Futrell, Nathanael S. Gray, Stephanie B. Hatch, Stefan Knapp, Ulrich Lücking, Michael Michaelides, Caitlin E. Mills, Susanne Müller, Dafydd Owen, Alfredo Picado, Kumar S. Saikatendu, Martin Schröder, Alexandra Stolz, Mariana Tellechea, Brandon J. Turunen, Santiago Vilar, Jinhua Wang, William J. Zuercher, Timothy M. Willson, David H. Drewry
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 566 (2021)
We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity
Externí odkaz:
https://doaj.org/article/98332da56c7a48cebc35217b75e5dc25
Autor:
Santiago Vilar, Daniel G. Isom
Publikováno v:
Biology, Vol 10, Iss 2, p 91 (2021)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide crisis with profound effects on both public health and the economy. In order to combat the COVID-19 pandemic, research groups have shared viral genome sequence data t
Externí odkaz:
https://doaj.org/article/397a93e5db9548969e8c3a791a7b53e0
Autor:
Saleta Vazquez-Rodriguez, Santiago Vilar, Sonja Kachler, Karl-Norbert Klotz, Eugenio Uriarte, Fernanda Borges, Maria João Matos
Publikováno v:
Molecules, Vol 25, Iss 18, p 4306 (2020)
Adenosine receptors (ARs) play an important role in neurological and psychiatric disorders such as Alzheimer’s disease, Parkinson’s disease, epilepsy and schizophrenia. The different subtypes of ARs and the knowledge on their densities and status
Externí odkaz:
https://doaj.org/article/c37473a590204b378004fac5703d705d
Autor:
Sofia Benfeito, Carlos Fernandes, Santiago Vilar, Fernando Remião, Eugenio Uriarte, Fernanda Borges
Publikováno v:
Molecules, Vol 25, Iss 2, p 276 (2020)
Alzheimer disease (AD) is the most common neurodegenerative disease featuring progressive and degenerative neurological impairments resulting in memory loss and cognitive decline. The specific mechanisms underlying AD are still poorly understood, but
Externí odkaz:
https://doaj.org/article/82fe629f759b455f9eaab12bcf6e0622
Autor:
Catarina Oliveira, Fernando Cagide, José Teixeira, Ricardo Amorim, Lisa Sequeira, Francesco Mesiti, Tiago Silva, Jorge Garrido, Fernando Remião, Santiago Vilar, Eugenio Uriarte, Paulo J. Oliveira, Fernanda Borges
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
Alzheimer's disease (AD) is a multifactorial age-related disease associated with oxidative stress (OS) and impaired cholinergic transmission. Accordingly, targeting mitochondrial OS and restoring cholinergic transmission can be an effective therapeut
Externí odkaz:
https://doaj.org/article/420a5a4aed444aff935b042fb4e8a4d3
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129974 (2015)
Identification of Drug-Drug Interactions (DDIs) is a significant challenge during drug development and clinical practice. DDIs are responsible for many adverse drug effects (ADEs), decreasing patient quality of life and causing higher care expenses.
Externí odkaz:
https://doaj.org/article/861dcd0b1fdb4806b13130a99765145a
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58321 (2013)
Drug-drug interactions (DDIs) constitute an important problem in postmarketing pharmacovigilance and in the development of new drugs. The effectiveness or toxicity of a medication could be affected by the co-administration of other drugs that share p
Externí odkaz:
https://doaj.org/article/d6ebfb1a5a1d4bcbb7c9827bb2af23a0
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41471 (2012)
Adverse drug events (ADEs) detection and assessment is at the center of pharmacovigilance. Data mining of systems, such as FDA's Adverse Event Reporting System (AERS) and more recently, Electronic Health Records (EHRs), can aid in the automatic detec
Externí odkaz:
https://doaj.org/article/5bfc109cce1e4168bac515b9e4ecb81b
Autor:
Santiago Vilar-González
Publikováno v:
Gaceta Mexicana de Oncolog�a. 16
Se realiza una revision sistematica de los estudios publicados en PubMed acerca de la relacion existente entre el cancer prostatico y los anticoagulantes, en especial la aspirina. Por otro lado, se analiza el posible mecanismo aditivo o sinergico de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57bddb2ba9a1127a3c9f47f0ff3f5d92
https://doi.org/10.24875/j.gamo.m17000060
https://doi.org/10.24875/j.gamo.m17000060
Autor:
Santiago Vilar-González
Publikováno v:
Gaceta Mexicana de Oncolog�a. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::923283f571345bba8c35c5e61a0b8d0d
https://doi.org/10.24875/j.gamo.m17000070
https://doi.org/10.24875/j.gamo.m17000070