Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Santiago V, Salazar"'
Autor:
Laura T. Haas, Santiago V. Salazar, Levi M. Smith, Helen R. Zhao, Timothy O. Cox, Charlotte S. Herber, Andrew P. Degnan, Anand Balakrishnan, John E. Macor, Charles F. Albright, Stephen M. Strittmatter
Publikováno v:
Cell Reports, Vol 20, Iss 1, Pp 76-88 (2017)
Metabotropic glutamate receptor 5 (mGluR5) has been implicated in Alzheimer’s disease (AD) pathology. We sought to understand whether mGluR5’s role in AD requires glutamate signaling. We used a potent mGluR5 silent allosteric modulator (SAM, BMS-
Externí odkaz:
https://doaj.org/article/5b136f6e60cd4bbaa20c897785936a15
Autor:
A. Harrison Brody, Suho Lee, Annabel S. Chyung, Santiago V. Salazar, Timothy O. Cox, Laura T. Haas, Stephen M. Strittmatter
Publikováno v:
The Journal of Neuroscience. 39:758-772
Dozens of genes have been implicated in late onset Alzheimer's disease (AD) risk, but none has a defined mechanism of action in neurons. Here, we show that the risk factor Pyk2 (PTK2B) localizes specifically to neurons in adult brain. Absence of Pyk2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81909e93e1c817c8e63a4dea3c51b89
https://doi.org/10.1523/jneurosci.1873-18.2018
https://doi.org/10.1523/jneurosci.1873-18.2018
Autor:
Sophie A. Robinson, Christopher Gallardo, Charlotte Herber, Jean Manson, Laura T. Haas, Stephen M. Strittmatter, Santiago V. Salazar, Adam C. Kaufman, Michael K. Lee
Publikováno v:
Salazar, S, Gallardo, C, Kaufman, A, Herber, C, Haas, L, Robinson, S, Manson, J, Lee, M & Strittmatter, S 2017, ' Conditional Deletion of Prnp Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's Disease ', Journal of Neuroscience, vol. 37, no. 38, pp. 9207-9221 . https://doi.org/10.1523/JNEUROSCI.0722-17.2017
Biochemical and genetic evidence implicate soluble oligomeric amyloid-β (Aβo) in triggering Alzheimer's disease (AD) pathophysiology. Moreover, constitutive deletion of the Aβo-binding cellular prion protein (PrPC) prevents development of memory d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ddfaaa0f18a72be240ae244611a4ca
https://doi.org/10.1523/jneurosci.0722-17.2017
https://doi.org/10.1523/jneurosci.0722-17.2017
Autor:
Santiago V. Salazar, Adiljan Ibrahim, Tina Schwabe, Philip Kong, Herve Rhinn, Arnon Rosenthal, Seung-Joo Lee, Ilaria Tassi
Publikováno v:
Alzheimer's & Dementia. 15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c38f1060331a272284a2d3156859959
https://doi.org/10.1016/j.jalz.2019.06.4560
https://doi.org/10.1016/j.jalz.2019.06.4560
The intracellular tyrosine kinase Pyk2 (PTK2B) is related to focal adhesion kinase and localizes to postsynaptic sites in brain. Pyk2 genetic variation contributes to late onset Alzheimer's disease (AD) risk. We recently observed that Pyk2 is require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53ddabe53e4b36a2ab9123f8751533c
https://europepmc.org/articles/PMC6407289/
https://europepmc.org/articles/PMC6407289/
Autor:
Amanda T. Jeng, Jinhee Yang, Stephen M. Strittmatter, Haakon B. Nygaard, Mikhail A. Kostylev, Sophie A. Robinson, Santiago V. Salazar, Adam C. Kaufman, Christopher H. van Dyck, Laura T. Haas, Erik C. Gunther
Publikováno v:
Annals of Neurology. 77:953-971
Objective Currently no effective disease-modifying agents exist for the treatment of Alzheimer disease (AD). The Fyn tyrosine kinase is implicated in AD pathology triggered by amyloid-s oligomers (Aso) and propagated by Tau. Thus, Fyn inhibition may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2b3ea648255ef3232fc7fdf976b63db
https://doi.org/10.1002/ana.24394
https://doi.org/10.1002/ana.24394
Autor:
Santiago V, Salazar, Christopher, Gallardo, Adam C, Kaufman, Charlotte S, Herber, Laura T, Haas, Sophie, Robinson, Jean C, Manson, Michael K, Lee, Stephen M, Strittmatter
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(38)
Biochemical and genetic evidence implicate soluble oligomeric amyloid-β (Aβo) in triggering Alzheimer's disease (AD) pathophysiology. Moreover, constitutive deletion of the Aβo-binding cellular prion protein (PrPC) prevents development of memory d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::daf3e40d4f7803bd700889e1c388b0be
https://pubmed.ncbi.nlm.nih.gov/28842420
https://pubmed.ncbi.nlm.nih.gov/28842420
Publikováno v:
Biochemical and biophysical research communications. 483(4)
Soluble oligomers of amyloid-beta (Aβo) are implicated by biochemical and genetic evidence as a trigger for Alzheimer's disease (AD) pathophysiology. A key step is Aβo interaction with the neuronal surface to initiate a cascade of altered signal tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34dfdc39709d83a3dd413b43c60e70a9
https://pubmed.ncbi.nlm.nih.gov/27639648
https://pubmed.ncbi.nlm.nih.gov/27639648
Autor:
Adam C. Kaufman, Mikhail A. Kostylev, Ji Won Um, Santiago V. Salazar, Stephen M. Strittmatter, Laura T. Haas
Alzheimer's disease-related phenotypes in mice can be rescued by blockade of either cellular prion protein or metabotropic glutamate receptor 5. We sought genetic and biochemical evidence that these proteins function cooperatively as an obligate comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30184080df83550e0b10e830ebbb9d53
https://europepmc.org/articles/PMC4840505/
https://europepmc.org/articles/PMC4840505/
Autor:
Laura T. Haas, Santiago V. Salazar, Adam C. Kaufman, Mikhail A. Kostylev, Stephen M. Strittmatter
Publikováno v:
Alzheimer's & Dementia. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f290a4938eb3f2178c71948baa3c6ba6
https://doi.org/10.1016/j.jalz.2015.07.428
https://doi.org/10.1016/j.jalz.2015.07.428