Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Santiago Ramón‐Maiques"'
Autor:
Rosario Francisco-Velilla, Azman Embarc-Buh, Salvador Abellan, Francisco del Caño-Ochoa, Santiago Ramón-Maiques, Encarnacion Martinez-Salas
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 6182-6191 (2022)
Gemin5 is a multifunctional RNA binding protein (RBP) organized in domains with a distinctive structural organization. The protein is a hub for several protein networks performing diverse RNA-dependent functions including regulation of translation, a
Externí odkaz:
https://doaj.org/article/11165f1e4822453bbbe1cfc1803de8a1
Autor:
Leo Bellin, Francisco Del Caño-Ochoa, Adrián Velázquez-Campoy, Torsten Möhlmann, Santiago Ramón-Maiques
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Aspartate transcarbamoylase acts in de novo pyrimidine biosynthesis and in plants is regulated by feedback inhibition via uridine 5-monophosphate (UMP). Here Bellin et al. describe the structural basis for this feedback inhibition, showing that UMP b
Externí odkaz:
https://doaj.org/article/770689c4d26f4402950ea9d01077e796
Publikováno v:
Molecules, Vol 28, Iss 2, p 660 (2023)
CAD is a 1.5 MDa hexameric protein with four enzymatic domains responsible for initiating de novo biosynthesis of pyrimidines nucleotides: glutaminase, carbamoyl phosphate synthetase, aspartate transcarbamoylase (ATC), and dihydroorotase. Despite its
Externí odkaz:
https://doaj.org/article/6dfa8a389fd54530933797eccd34d691
Autor:
Nada Lallous, Pierre Legrand, Alastair G McEwen, Santiago Ramón-Maiques, Jean-Pierre Samama, Catherine Birck
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27599 (2011)
The human UHRF1 protein (ubiquitin-like containing PHD and RING finger domains 1) has emerged as a potential cancer target due to its implication in cell cycle regulation, maintenance of DNA methylation after replication and heterochromatin formation
Externí odkaz:
https://doaj.org/article/7735bc4d7b0448b0b79ac24617ac673a
Autor:
Geen-Dong Chang, Ming-Shyue Lee, Chao-Chi Ho, Santiago Ramón-Maiques, Francisco Del Caño-Ochoa, Ya-Hui Chuang, I-Chun Chen, Der-Yen Lee, Chia-Chi Ku, Hsin-Ying Lin, Hsin-Hsien Lin, Shao-Wei Lan, Cheng-Fan Lee, Ching-Tai Lee, Chun-Jung Ko, Hsin-Fang Tu
Current clinical trials of combined EGFR-tyrosine kinase inhibitors (TKI) and immune checkpoint blockade (ICB) therapies show no additional effect. This raises questions regarding whether EGFR-TKIs attenuate ICB-enhanced CD8+ T lymphocyte function. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db98134cf3aa0654ea889866ceb5042
https://doi.org/10.1158/0008-5472.c.6513067
https://doi.org/10.1158/0008-5472.c.6513067
Autor:
Geen-Dong Chang, Ming-Shyue Lee, Chao-Chi Ho, Santiago Ramón-Maiques, Francisco Del Caño-Ochoa, Ya-Hui Chuang, I-Chun Chen, Der-Yen Lee, Chia-Chi Ku, Hsin-Ying Lin, Hsin-Hsien Lin, Shao-Wei Lan, Cheng-Fan Lee, Ching-Tai Lee, Chun-Jung Ko, Hsin-Fang Tu
It includes supplementary material and method, one table, and figure and figure legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629f5b22ff169c649d6b42f3af13f7ba
https://doi.org/10.1158/0008-5472.22428547.v1
https://doi.org/10.1158/0008-5472.22428547.v1
Autor:
Irene Bravo‐Alonso, Matías Morin, Laura Arribas‐Carreira, Mar Álvarez, Consuelo Pedrón‐Giner, Lucia Soletto, Carlos Santolaria, Santiago Ramón‐Maiques, Magdalena Ugarte, Pilar Rodríguez‐Pombo, Joaquín Ariño, Miguel Ángel Moreno‐Pelayo, Belén Pérez
Publikováno v:
Journal of inherited metabolic diseaseREFERENCES.
12 páginas, 6 figuras
Coenzyme A (CoA) is an essential cofactor involved in a range of metabolic pathways including the activation of long-chain fatty acids for catabolism. Cells synthesize CoA de novo from vitamin B5 (pantothenate) via a pathw
Coenzyme A (CoA) is an essential cofactor involved in a range of metabolic pathways including the activation of long-chain fatty acids for catabolism. Cells synthesize CoA de novo from vitamin B5 (pantothenate) via a pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98c457713d4d31523cbcde5abd97d49
https://pubmed.ncbi.nlm.nih.gov/36564894
https://pubmed.ncbi.nlm.nih.gov/36564894
Publikováno v:
Protein Science : A Publication of the Protein Society
CAD is a 1.5 MDa particle formed by hexameric association of a 250 kDa protein divided into different enzymatic domains, each catalyzing one of the initial reactions for de novo biosynthesis of pyrimidine nucleotides: glutaminase‐dependent Carbamoy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88fcca9e4e9369483783db44e8f29f68
https://doi.org/10.1002/pro.4158
https://doi.org/10.1002/pro.4158
Autor:
Cristina Segovia‐Falquina, Alicia Vilas, Fátima Leal, Francisco del Caño‐Ochoa, Edwin P. Kirk, Magdalena Ugarte, Santiago Ramón‐Maiques, Alejandra Gámez, Belén Pérez
Publikováno v:
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
13 páginas, 4 figuras 2 tablas
Different strategies are being investigated for treating PMM2-CDG, the most common congenital disorder of glycosylation. The use of pharmacochaperones (PCs) is one of the most promising. The present work character
Different strategies are being investigated for treating PMM2-CDG, the most common congenital disorder of glycosylation. The use of pharmacochaperones (PCs) is one of the most promising. The present work character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2ce7311b8dec5207ade45fa6d42eb9
https://doi.org/10.1002/humu.24431
https://doi.org/10.1002/humu.24431
Autor:
Rosario Francisco-Velilla, Azman Embarc-Buh, Francisco del Caño-Ochoa, Salvador Abellan, Marçal Vilar, Sara Alvarez, Alberto Fernandez-Jaen, Sukhleen Kour, Deepa S Rajan, Udai Bhan Pandey, Santiago Ramón-Maiques, Encarnacion Martinez-Salas
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
16 páginas, 7 figuras, 1 tabla. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE (Perez-Riverolet al, 2019) partner repository with the dataset identifier PXD028959 and PXD028959. All data gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3625a1c0d1a034d5364b3388ce739d2
http://hdl.handle.net/10261/274643
http://hdl.handle.net/10261/274643