Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin

Autor: Chengliang Wang, Puja Kumari, Chuan Li, Gabriel A. Rabinovich, Margaret M. Fettis, Sachin D. Deshmukh, Arun Wanchoo, Anthony T. Vella, Shivalee Duduskar, Gregory A. Hudalla, Christoph Sponholz, Beiyan Zhou, Michael Bauer, Ashley J. Russo, Renjie Liu, Vijay A. K. Rathinam, Santiago P. Méndez-Huergo, Jianbin Ruan, Sivapriya Kailasan Vanaja, Juan M. Pérez Sáez, Karthik Chandiran, Swathy O. Vasudevan, Antoine Ménoret

Publikováno v: Nat Immunol

Inflammatory caspase sensing of cytosolic lipopolysaccharide (LPS) triggers pyroptosis and the concurrent release of damage-associated molecular patterns (DAMPs). Collectively, DAMPs are key determinants that shape the aftermath of inflammatory cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd368de112bdf46f79b07a7aa7e0a0d
https://doi.org/10.1038/s41590-020-00844-7

Characterization of a neutralizing anti-human galectin-1 monoclonal antibody with angioregulatory and immunomodulatory activities

Autor: Juan M, Pérez Sáez, Pablo F, Hockl, Alejando J, Cagnoni, Santiago P, Méndez Huergo, Pablo A, García, Sabrina G, Gatto, Juan P, Cerliani, Diego O, Croci, Gabriel A, Rabinovich

Publikováno v: Angiogenesis. 24(1)

Galectins, a family of highly conserved β-galactoside-binding proteins, control tumor progression by modulating different hallmarks of cancer. Galectin-1 (Gal-1), a proto-type member of this family, plays essential roles in tumor angiogenesis and im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bf28b0974d450df03e26dcc1cec42a49
https://pubmed.ncbi.nlm.nih.gov/33006019

Glioblastomas exploit truncated O-linked glycans for local and distant immune modulation via the macrophage galactose-type lectin

Autor: Xandra O. Breakefield, Valerie M C J Wouters, Thomas Wurdinger, David P. Noske, Pieter Wesseling, Santiago P. Méndez-Huergo, Gabriel A. Rabinovich, Erik R. Abels, Sandra J. van Vliet, Elena de Miguel, Ernesto Rodríguez, Juan J. Garcia-Vallejo, Lisan H Kuijper, Lenneke A.M. Cornelissen, Sophie A. Dusoswa, Jan Verhoeff, Diego O. Croci, Yvette van Kooyk, Marike L. D. Broekman, Myron G. Best

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 117(7), 3693-3703. National Academy of Sciences
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Dusoswa, S A, Verhoeff, J, Abels, E, Méndez-Huergo, S P, Croci, D O, Kuijper, L H, de Miguel, E, Wouters, V M C J, Best, M G, Rodriguez, E, Cornelissen, L A M, van Vliet, S J, Wesseling, P, Breakefield, X O, Noske, D P, Würdinger, T, Broekman, M L D, Rabinovich, G A, van Kooyk, Y & Garcia-Vallejo, J J 2020, ' Glioblastomas exploit truncated O-linked glycans for local and distant immune modulation via the macrophage galactose-type lectin ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 7, pp. 3693-3703 . https://doi.org/10.1073/pnas.1907921117
Proc Natl Acad Sci U S A

Glioblastoma is the most aggressive brain malignancy, for which immunotherapy has failed to prolong survival. Glioblastoma-associated immune infiltrates are dominated by tumor-associated macrophages and microglia (TAMs), which are key mediators of im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17458e6988b2744ce2b0ec33f13ca8e5
https://pure.amc.nl/en/publications/glioblastomas-exploit-truncated-olinked-glycans-for-local-and-distant-immune-modulation-via-the-macrophage-galactosetype-lectin(8996ccab-06f2-4957-ab23-f290223c0957).html

Galectins: emerging regulatory checkpoints linking tumor immunity and angiogenesis

Autor: Gabriel A. Rabinovich, Ada G. Blidner, Santiago P. Méndez-Huergo

Publikováno v: Current Opinion in Immunology. 45:8-15

Immune checkpoints, a plethora of inhibitory pathways aimed at maintaining immune cell homeostasis, may be co-opted by cancer cells to evade immune destruction. Therapies targeting immune checkpoints have reached a momentum yielding significant clini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8add3dbb881c360b87975dac85067e0b
https://doi.org/10.1016/j.coi.2016.12.003

Clinical relevance of galectin-1 and galectin-3 in rheumatoid arthritis patients: Differential regulation and correlation with disease activity

Autor: Sebastian Matias Maller, Santiago P. Méndez-Huergo, Nicolás A. Pinto, Luciano Gastón Morosi, Pablo F. Hockl, Juan C. Stupirski, Gabriel A. Rabinovich, Javier A. Cavallasca, Jorge L. Musuruana, G Nasswetter, AM Beron

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2019)

Galectins, a family of animal lectins, play central roles in immune system regulation, shaping both innate and adaptive responses in physiological and pathological processes. These include rheumatoid arthritis (RA), a chronic multifactorial autoimmun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88cca94fae746fe81975e4a024069878
https://www.frontiersin.org/articles/10.3389/fimmu.2018.03057/full