Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Santiago Morell"'
Autor:
Sonia Morales-Santana, Santiago Morell, Josefa Leon, Angel Carazo-Gallego, Jose C. Jimenez-Lopez, María Morell
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
A major consequence of the world industrialized lifestyle is the increasing period of unnatural light in environments during the day and artificial lighting at night. This major change disrupts endogenous homeostasis with external circadian cues, whi
Externí odkaz:
https://doaj.org/article/0fca5f86aead45c3b772d12f861e36b0
Autor:
Gabriela O. Bodea, Maria E. Ferreiro, Francisco J. Sanchez-Luque, Juan M. Botto, Jay Rasmussen, Muhammed A. Rahman, Laura R. Fenlon, Carolina Gubert, Patricia Gerdes, Liviu-Gabriel Bodea, Prabha Ajjikuttira, Peter Kozulin, Victor Billon, Santiago Morell, Marie-Jeanne H.C. Kempen, Chloe J. Love, Lucy M. Palmer, Adam D. Ewing, Dhanisha J. Jhaveri, Sandra R. Richardson, Anthony J. Hannan, Geoffrey J. Faulkner
Transposable elements (TEs) are a reservoir of new transcription factor binding sites for protein-coding genes1–3. Developmental programs that activate TE-derived regulatory elements could, in principle, manifest in lineage-specific TE mobility. Wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af7e5b858fbba1785426a883c679386d
https://doi.org/10.1101/2022.03.20.485017
https://doi.org/10.1101/2022.03.20.485017
Autor:
Jose L. Garcia-Perez, Sara R. Heras, Belen Toledo, Laura Sánchez, Pablo Tristan-Ramos, Santiago Morell
Publikováno v:
Philos Trans R Soc Lond B Biol Sci
The cell culture-based retrotransposition reporter assay has been (and is) an essential tool for the study of vertebrate Long INterspersed Elements (LINEs). Developed more than 20 years ago, this assay has been instrumental in characterizing the role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1442fcc226cb13ac703389fa234e5040
https://doi.org/10.1098/rstb.2019.0346
https://doi.org/10.1098/rstb.2019.0346
Autor:
Valentin Sanchez-Carnerero, Carmen Salvador-Palomeque, Juan A. Tamayo, Pablo Tristan-Ramos, Laura Sánchez, Guillermo Banuelos-Sanchez, Jose L. Garcia-Perez, Maria Benitez-Guijarro, Santiago Morell, Jose L. Garcia-Puche, Francisco Franco-Montalban, Sara R. Heras, Meriem Benkaddour-Boumzaouad
Publikováno v:
Cell Chemical Biology. 26:1095-1109.e14
Retrotransposons are a type of transposable element (TE) that have amplified to astonishing numbers in mammalian genomes, comprising more than a third of the human and mouse genomes. Long interspersed element class 1 (LINE-1 or L1) retrotransposons a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbaa94304568032681ea3ddcab670aad
https://doi.org/10.1016/j.chembiol.2019.04.010
https://doi.org/10.1016/j.chembiol.2019.04.010
Autor:
Paul Brennan, Allister C. Fagg, Daniel J. Gerhardt, Stephanie N. Schauer, Kyle R. Upton, Geoffrey J. Faulkner, Patricia E. Carreira, Sandra R. Richardson, Jun Wang, Adam D. Ewing, Michaela Kindlova, Santiago Morell, Bo Li, Patricia Gerdes, Guibo Li
Publikováno v:
Carreira, P E, Ewing, A D, Li, G, Schauer, S N, Upton, K R, Fagg, A C, Morell, S, Kindlova, M, Gerdes, P, Richardson, S R, Li, B, Gerhardt, D J, Wang, J, Brennan, P M & Faulkner, G J 2016, ' Evidence for L1-associated DNA rearrangements and negligible L1 retrotransposition in glioblastoma multiforme ', Mobile D N A, vol. 7, 21 . https://doi.org/10.1186/s13100-016-0076-6
Mobile DNA
Carreira, P, Ewing, A D, Li, G, Schauer, S N, Upton, K R, Fagg, A C, Morell, S, Kindlova, M, Gerdes, P, Richardson, S R, Li, B, Gerhardt, D J, Jun, W, Brennan, P & Faulkner, G J 2016, ' Evidence for L1-associated DNA rearrangements and negligible L1 retrotransposition in glioblastoma multiforme ', Mobile DNA . https://doi.org/10.1186/s13100-016-0076-6
Mobile DNA
Carreira, P, Ewing, A D, Li, G, Schauer, S N, Upton, K R, Fagg, A C, Morell, S, Kindlova, M, Gerdes, P, Richardson, S R, Li, B, Gerhardt, D J, Jun, W, Brennan, P & Faulkner, G J 2016, ' Evidence for L1-associated DNA rearrangements and negligible L1 retrotransposition in glioblastoma multiforme ', Mobile DNA . https://doi.org/10.1186/s13100-016-0076-6
Background LINE-1 (L1) retrotransposons are a notable endogenous source of mutagenesis in mammals. Notably, cancer cells can support unusual L1 retrotransposition and L1-associated sequence rearrangement mechanisms following DNA damage. Recent report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8bc7cae257c727501f9cc064295b1e
https://zenodo.org/record/166405
https://zenodo.org/record/166405
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1400
Long Interspersed Element class 1 retrotransposons (LINE-1 or L1) are abundant Transposable Elements in mammalian genomes and their mobility continues to impact the human genome. The development of engineered retrotransposition assays has been instru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a455ca3de208e2a87162306698dfb31b
https://pubmed.ncbi.nlm.nih.gov/26895054
https://pubmed.ncbi.nlm.nih.gov/26895054
Publikováno v:
Methods in Molecular Biology ISBN: 9781493933709
Transposons and Retrotransposons
Transposons and Retrotransposons
Long Interspersed Element class 1 retrotransposons (LINE-1 or L1) are abundant Transposable Elements in mammalian genomes and their mobility continues to impact the human genome. The development of engineered retrotransposition assays has been instru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40674dc30e6c16d71c84ee408d1dc419
https://doi.org/10.1007/978-1-4939-3372-3_12
https://doi.org/10.1007/978-1-4939-3372-3_12
Autor:
Santiago Morell, Angela Macia, José Luis Cortés, Robert K. Hastings, Juan A. Marchal, Jose L. Garcia-Perez, Gema Lucena-Aguilar, Martin Muñoz-Lopez, Richard M. Badge
Publikováno v:
Molecular and Cellular Biology. 31:300-316
Long interspersed element 1s (LINE-1s or L1s) are a family of non-long-terminal-repeat retrotransposons that predominate in the human genome. Active LINE-1 elements encode proteins required for their mobilization. L1-encoded proteins also act in tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3775a5708c7cf8adec4284aef75e36c6
https://doi.org/10.1128/mcb.00561-10
https://doi.org/10.1128/mcb.00561-10
Autor:
Joshua O. Scheys, Pablo Menendez, K. Sue O'Shea, Santiago Morell, Deanna A. Kulpa, Kathleen L. Collins, Jose L. Garcia-Perez, Maria Morell, Christoph C. Carter, John V. Moran, Gary D. Hammer
Publikováno v:
Nature
Long INterspersed Element-1 (LINE-1 or L1) retrotransposition continues to impact human genome evolution1,2. L1s can retrotranspose in the germline, during early development, and in select somatic cells3,4,5,6,7,8; however, the host response to L1 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd91fe3cd0b9837254a4d739ce20069
https://doi.org/10.1038/nature09209
https://doi.org/10.1038/nature09209
Publikováno v:
Annual review of genetics. 48
Long interspersed element 1 (LINE-1 or L1) retrotransposons have generated one-third of the human genome, and their ongoing mobility is a source of inter- and intraindividual genetic diversity. Although retrotransposition in metazoans has long been c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a428d3f066853f3c213ef7035e0a73
https://pubmed.ncbi.nlm.nih.gov/25036377
https://pubmed.ncbi.nlm.nih.gov/25036377