Epigenetic Clock Explains White Matter Hyperintensity Burden Irrespective of Chronological Age

Autor: Joan Jiménez-Balado, Eva Giralt-Steinhauer, Isabel Fernández-Pérez, Lucía Rey, Elisa Cuadrado-Godia, Ángel Ois, Ana Rodríguez-Campello, Carolina Soriano-Tárraga, Uxue Lazcano, Adrià Macias-Gómez, Antoni Suárez-Pérez, Anna Revert, Isabel Estragués, Brigitte Beltrán-Mármol, Santiago Medrano-Martorell, Jaume Capellades, Jaume Roquer, Jordi Jiménez-Conde

Publikováno v: Biology, Vol 12, Iss 1, p 33 (2022)

In this manuscript we studied the relationship between WMH and biological age (B-age) in patients with acute stroke. We included in this study 247 patients with acute stroke recruited at Hospital del Mar having both epigenetic (DNA methylation) and m

Externí odkaz: https://doaj.org/article/6a31d6b532224b41a62052d0a99e1b3f

Persistent lymph nodes after curative chemoradiotherapy for head and neck cancer: imaging predictors of response for decision-making

Autor: Alfredo Páez-Carpio, Santiago Medrano-Martorell, Joan Berenguer, Africa Muxí, Isabel Vilaseca, Izaskun Valduvieco, Paola Castillo, Neus Baste, F. Xavier Avilés-Jurado, Juan José Grau, Laura Oleaga

Publikováno v: European Archives of Oto-Rhino-Laryngology. 280:1369-1379

To identify response predictors in patients with head and neck squamous cell carcinoma (N + HNSCC) and persistent lymph nodes after curative chemoradiotherapy treatment (CCRT).Consecutive patients with N + HNSCC treated with CCRT and persistent lymph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6254de71665d0d61bcd786177b6caf78
https://doi.org/10.1007/s00405-022-07658-3

Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

Autor: Henry Ma, Eleni Sakka, Hugues Chabriat, Duncan Wilson, Appu Suman, Peter J. Kelly, SL Ho, Charlotte Zerna, Eric Jouvent, Lawrence K.S. Wong, Anthea Parry, Frances Harrington, Jan Stam, Christopher Patterson, Rustam Al-Shahi Salman, Shigeru Inamura, Krishna A Dani, Henry Houlden, Sebastian Thilemann, Kotaro Iida, Chao Xu, Eunbin Ko, Daniel Guisado-Alonso, Urs Fischer, Caroline E. Lovelock, Man Yu Tse, Wing Chi Fong, Azlisham Mohd Nor, Clare Shakeshaft, Philippe Maeder, Henrik Gensicke, Stefan T. Engelter, James Okwera, Christopher Chen, Dulka Manawadu, John F. Corrigan, Efrat Kliper, Shelagh B. Coutts, Alexander P. Leff, Kam Tat Leung, Chathuri Yatawara, Leopold Hertzberger, M. Eline Kooi, Kazuhisa Yoshifuji, Hing Lung Ip, Keon-Joo Lee, Sanjeevikumar Meenakishundaram, Hiroyuki Irie, Marc Randall, Hatice Ozkan, Hideo Hara, Jill Abrigo, Raquel Delgado-Mederos, Shaloo Singhal, Enrico Flossmann, Beatriz Gómez-Ansón, Paul O'Mahony, Carmen Barbato, Ahamad Hassan, Francesca M Chappell, Harald Proschel, Vincent Mok, Masashi Nishihara, Lakshmanan Sekaran, Derya Selcuk Demirelli, Chu Peng Hoi, Hakan Ay, Joan Martí-Fàbregas, Rebeca Marín, Anne Cristine Guevarra, Martin Cooper, Einor Ben Assayag, Anne-Marie Mendyk, Christine Roffe, Myung Suk Jang, Maarten van Gemert, Hannah Cohen, Jae-Sung Lim, YK Wong, Bonnie Y.K. Lam, Janet Putterill, Wouter Schoonewille, Nick S. Ward, Nikola Sprigg, Kui Kai Lau, Bernard Esisi, Peter M. Rothwell, Henk Verbiest, Kirsty Harkness, Elisa Merino, Gareth Ambler, Arumug Nallasivam, Nigel Smyth, Paul A. Armitage, Heinrich Mattle, Pol Camps-Renom, Martin M. Brown, David Cohen, Min Lou, Pankaj Sharma, Sarah Gunkel, Elles Douven, Andreas Charidimou, Djamil Vahidassr, Cathy Soufan, Alexandros A Polymeris, Michael G. Hennerici, Chris Moran, Rachel Marsh, Mahmud Sajid, Kyohei Fujita, David J. Werring, Joanna M. Wardlaw, Derek Hayden, Joseph Kwan, Timothy J. England, Jaap van der Sande, Luis Prats-Sánchez, Paul Guyler, Ryan Hoi Kit Cheung, Koon-Ho Chan, Frank-Erik de Leeuw, Simone Browning, Jon Scott, Adrian Barry, Alejandro Martínez-Domeño, Luc Bracoub, Dinesh Chadha, Ijaz Anwar, Deborah Kelly, Moon-Ku Han, Anil M. Tuladhar, Thomas Gattringer, Fiona Carty, Abduelbaset Elmarim, Syed Mansoor, Enrico Flossman, Dilek Necioglu Orken, Jane Sword, Velandai Srikanth, Ping Wing Ng, Thomas W. Leung, Richard Shek-kwan Chang, Hans Rolf Jäger, Marwan El-Koussy, Jeroen Hendrikse, Khaled Darawil, Kazunori Toyoda, Mathuri Prabhakaran, Karim Mahawish, Ethem Murat Arsava, Jihoon Kang, Kwok Kui Wong, Michael Power, Felix Fluri, Enas Lawrence, Maam Mamun, Sissi Ispoglou, Mathew Burn, Siu Hung Li, Henry K.F. Mak, Kaori Miwa, Els De Schryver, Franz Fazekas, Jonathan G. Best, Louise Shaw, Hen Hallevi, Keith W. Muir, Ilse Burger, Adrian Wong, Nils Peters, Susana Muñoz-Maniega, Yusuke Yakushiji, David Calvet, Mark White, Michael McCormick, Vinodh Krishnamurthy, David Hargroves, Jan C. Purrucker, Tae Jin Song, Masayuki Shiozawa, Noortje A.M. Maaijwee, Prasanna Aghoram, Nicolas Christ, Lino Ramos, Yannie Soo, Thanh G. Phan, Parashkev Nachev, David J. Seiffge, Kim Wiegertjes, Leo H. Bonati, Chahin Pachai, Oi Ling Chan, Yvo B.W.E.M. Roos, Santiago Medrano-Martorell, Natan M. Bornstein, Elizabeth A. Warburton, Richard Li, Prabel Datta, Pascal P. Gratz, Edmund Ka Ming Wong, Hedley C. A. Emsley, Marie-Yvonne Douste-Blazy, Gunaratam Gunathilagan, Nagaendran Kandiah, Masatoshi Koga, Roland Veltkamp, Lee-Anne Slater, Suk Fung Tsang, Beom Joon Kim, Simon Jung, Zeynep Tanriverdi, Sarah Caine, Peter J. Koudstaal, Laurence Legrand, Kari Saastamoinen, Ale Algra, Jean-Louis Mas, Christine Delmaire, Fidel Nuñez, Robert J. van Oostenbrugge, Sebastian Eppinger, Lillian Choy, Robert Luder, Vincent I.H. Kwa, Aad van der Lugt, Marie Dominique Fratacci, Stephen Makin, Layan Akijian, Régis Bordet, Mi Hwa Yang, Ying Zhou, Elio Giallombardo, Adrian R Parry-Jones, John S. Thornton, Amos D. Korczyn, Narayanaswamy Venketasubramanian, David J. Williams, Aravindakshan Manoj, Julie Staals, Solveig Horstmann, Dianne H.K. van Dam-Nolen, Claire Cullen, Benjamin Wagner, Jun Tanaka, Martin Dennis, Stef Bakker, Gregory Y.H. Lip, L. Jaap Kappelle, Robin Lemmens, Achim Gass, David Mangion, Matthew Smith, Toshio Imaizumi, Wenyan Liu, Jeremy Molad, Christopher Price, Paul J. Nederkoorn, P. J. A. M. Brouwers, Vincent Thijs, Sze Ho Ma, Mark Schembri, Peter Wilkinson, Janice E. O’Connell, Karen Ma, John Ly, Leonidas Panos, Chung Yan Chan, Toshihiro Ide, Christopher Traenka, Joost Jöbsis, Gargi Banerjee, Paul Berntsen, Michael J. Thrippleton, Raymond T.F. Cheung, Christopher Karayiannis, Werner H. Mess, Robert Simister, Jayesh Modi Medanta, Syuhei Ikeda, John Mitchell, Linxin Li, Mauro S.B. Silva, Eric Vicaut, John Coyle, Shoichiro Sato, Michelle Davis, Jonathan Birns, Richard J. Perry, Sean M. Murphy, KC Teo, Maria del C. Valdés Hernández, Bibek Gyanwali, Tarek A. Yousry, Kath Pasco, Sebastian Köhler, Joachim Fladt, Edward S. Hui, Philippe Lyrer, Young Dae Kim, Anna K. Heye, Eric E. Smith, Saima Hilal, Ender Uysal, Ji Hoe Heo, Ysoline Beigneux, Cisca Linn, Hee-Joon Bae, Simon Leach, Winnie C.W. Chu, Ronil V. Chandra

Publikováno v: Best, J G, Ambler, G, Wilson, D, Lee, K J, Lim, J S, Shiozawa, M, Koga, M, Li, L, Lovelock, C, Chabriat, H, Hennerici, M, Wong, Y K, Mak, H K F, Prats-Sanchez, L, Martínez-Domeño, A, Inamura, S, Yoshifuji, K, Arsava, E M, Horstmann, S, Purrucker, J, Lam, B Y K, Wong, A, Kim, Y D, Song, T J, Lemmens, R, Eppinger, S, Gattringer, T, Uysal, E, Tanriverdi, Z, Bornstein, N M, Ben Assayag, E, Hallevi, H, Molad, J, Nishihara, M, Tanaka, J, Coutts, S B, Polymeris, A, Wagner, B, Seiffge, D J, Lyrer, P, Algra, A, Kappelle, L J, Al-Shahi Salman, R, Jäger, H R, Lip, G Y H, Fischer, U, El-Koussy, M, Mas, J L, Legrand, L, Karayiannis, C, Phan, T, Gunkel, S, Christ, N, Abrigo, J, Leung, T, Chu, W, Chappell, F, Makin, S, Hayden, D, Williams, D J, Mess, W H, Nederkoorn, P J, Barbato, C, Browning, S, Wiegertjes, K, Tuladhar, A M, Maaijwee, N, Guevarra, A C, Yatawara, C, Mendyk, A M, Delmaire, C, Köhler, S, van Oostenbrugge, R, Zhou, Y, Xu, C, Hilal, S, Gyanwali, B, Chen, C, Lou, M, Staals, J, Bordet, R, Kandiah, N, de Leeuw, F E, Simister, R, Hendrikse, J, Kelly, P J, Wardlaw, J, Soo, Y, Fluri, F, Srikanth, V, Calvet, D, Jung, S, Kwa, V I H, Engelter, S T, Peters, N, Smith, E E, Hara, H, Yakushiji, Y, Orken, D N, Fazekas, F, Thijs, V, Heo, J H, Mok, V, Veltkamp, R, Ay, H, Imaizumi, T, Gomez-Anson, B, Lau, K K, Jouvent, E, Rothwell, P M, Toyoda, K, Bae, H J, Marti-Fabregas, J, Werring, D J & Microbleeds International Collaborative Network 2021, ' Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack : a pooled analysis of individual patient data from cohort studies ', The Lancet Neurology, vol. 20, no. 4, pp. 294-303 . https://doi.org/10.1016/S1474-4422(21)00024-7
Lancet Neurology, 20, 4, pp. 294-303
Lancet Neurology, 20, 294-303
Best, J G, Ambler, G, Wilson, D, Lee, K, Lim, J, Shiozawa, M, Koga, M, Li, L, Lovelock, C, Chabriat, H, Hennerici, M, Wong, Y K, Mak, H K F, Prats-sanchez, L, Martínez-domeño, A, Inamura, S, Yoshifuji, K, Arsava, E M, Horstmann, S, Purrucker, J, Lam, B Y K, Wong, A, Kim, Y D, Song, T, Lemmens, R, Eppinger, S, Gattringer, T, Uysal, E, Tanriverdi, Z, Bornstein, N M, Ben Assayag, E, Al-shahi Salman, R, Chappell, F, Makin, S, Williams, D J, Zhou, Y, Wardlaw, J, Jung, S, Smith, M, Power, M, Muir, K, Hernández, M V, Armitage, P, Heye, A, Muñoz-maniega, S, Sakka, E, Thrippleton, M, Dennis, M & Perry, R & Mitchell, J 2021, ' Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies ', The Lancet Neurology, vol. 20, no. 4, pp. 294-303 . https://doi.org/10.1016/S1474-4422(21)00024-7
LANCET NEUROLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Instituto de Salud Carlos III (ISCIII)
Lancet neurology, 20(4), 294-303. Lancet Publishing Group
Lancet Neurology, 20(4), 294-303. Elsevier Science

Contains fulltext : 235277.pdf (Publisher’s version ) (Closed access) BACKGROUND: Balancing the risks of recurrent ischaemic stroke and intracranial haemorrhage is important for patients treated with antithrombotic therapy after ischaemic stroke or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663cff62b7c4a18e105e40a2c203a12f
http://www.scopus.com/inward/record.url?scp=85102586910&partnerID=8YFLogxK

Risk factors analysis according to regional distribution of white matter hyperintensities in a stroke cohort

Autor: Jaume Capellades, Jaume Roquer, Angel Ois, Santiago Medrano-Martorell, Isabel Fernández, Carla Avellaneda, Eva Giralt-Steinhauer, Sofía González-Ortiz, Ana Rodríguez-Campello, Marta Vilas-González, Jordi Jimenez-Conde, Elisa Cuadrado-Godia, Joan Martí-Fàbregas, Elisa Merino-Peña

Publikováno v: EUROPEAN RADIOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

The spectrum of distribution of white matter hyperintensities (WMH) may reflect different functional, histopathological, and etiological features. We examined the relationships between cerebrovascular risk factors (CVRF) and different patterns of WMH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::522b0f231503b315c276b519d79d8656
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4613

Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer’s disease in adults with Down syndrome

Autor: Kaj Blennow, Sylvain Lehmann, Nicholas J. Ashton, Jordi Pegueroles, Rafael Blesa, Maria Florencia Iulita, Alberto Lleó, Miren Altuna, Valle Camacho, Henrik Zetterberg, Maria Carmona-Iragui, Daniel Alcolea, Diana Garzón, Susana Fernández, Juan Lantero-Rodriguez, Santiago Medrano-Martorell, Juan Fortea, Jordi Clarimón, Thomas K. Karikari, Olivia Belbin, Alexandre Bejanin, Laura Videla, Sílvia Valldeneu, Bessy Benejam, Isabel Barroeta, Victor Montal

Publikováno v: Nature Communications
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.4304. ⟨10.1038/s41467-021-24319-x⟩
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona

Plasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer’s disease (AD) pathology with high accuracy in the general population. In this study, we investigated plasma p-tau181 as a biomarker of AD in individuals with Down syndrome (D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1265af7d15b7294e224b6f8386b92398
https://doi.org/10.1038/s41467-021-24319-x