Trypanosoma cruzi killing and immune response boosting by novel phenoxyhydrazine-thiazole against Chagas disease.

Autor: Cristovão-Silva AC; Laboratory of Immunopathology and Molecular Biology, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, 50670-42, Recife, Pernambuco, Brazil., Brelaz-de-Castro MCA; Laboratory of Immunopathology and Molecular Biology, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, 50670-42, Recife, Pernambuco, Brazil; Laboratory of Parasitology, Vitória Academic Center, Federal University of Pernambuco, 55608-680, Vitória de Santo Antão, Pernambuco, Brazil., Dionisio da Silva E; Laboratory of Immunopathology and Molecular Biology, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, 50670-42, Recife, Pernambuco, Brazil., Leite ACL; Laboratory of Planning and Synthesis in Medicinal Chemistry, Pharmaceutical Sciences Department, Federal University of Pernambuco, 50740-520, Recife, Pernambuco, Brazil., Santiago LBAA; Laboratory of Planning and Synthesis in Medicinal Chemistry, Pharmaceutical Sciences Department, Federal University of Pernambuco, 50740-520, Recife, Pernambuco, Brazil., Conceição JMD; Laboratory of Planning and Synthesis in Medicinal Chemistry, Pharmaceutical Sciences Department, Federal University of Pernambuco, 50740-520, Recife, Pernambuco, Brazil., da Silva Tiburcio R; Laboratory of Planning and Synthesis in Medicinal Chemistry, Pharmaceutical Sciences Department, Federal University of Pernambuco, 50740-520, Recife, Pernambuco, Brazil., de Santana DP; Pharmaceutical and Cosmetic Development Center (NUDFAC), Department of Pharmaceutical Science, Federal University of Pernambuco, Recife, PE, Brazil., Bedor DCG; Pharmaceutical and Cosmetic Development Center (NUDFAC), Department of Pharmaceutical Science, Federal University of Pernambuco, Recife, PE, Brazil., de Carvalho BÍV; Pharmaceutical and Cosmetic Development Center (NUDFAC), Department of Pharmaceutical Science, Federal University of Pernambuco, Recife, PE, Brazil., Ferreira LFGR; Laboratory of Theoretical and Medicinal Chemistry, Pharmaceutical Sciences Department, Federal University of Pernambuco, 50740-520, Recife, Pernambuco, Brazil., de Freitas E Silva R; Laboratory of Immunopathology and Molecular Biology, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, 50670-42, Recife, Pernambuco, Brazil. Electronic address: rafael.defreitasesilva@meduniwien.ac.at., Alves Pereira VR; Laboratory of Immunopathology and Molecular Biology, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, 50670-42, Recife, Pernambuco, Brazil. Electronic address: valeria.hernandes@fiocruz.br., Hernandes MZ; Laboratory of Theoretical and Medicinal Chemistry, Pharmaceutical Sciences Department, Federal University of Pernambuco, 50740-520, Recife, Pernambuco, Brazil. Electronic address: marcelo.hernandes@ufpe.br.

Publikováno v: Experimental parasitology [Exp Parasitol] 2024 Jun; Vol. 261, pp. 108749. Date of Electronic Publication: 2024 Apr 07.