Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Santiago Haase"'
Autor:
Brandon L. McClellan, Santiago Haase, Felipe J. Nunez, Mahmoud S. Alghamri, Ali A. Dabaja, Pedro R. Lowenstein, Maria G. Castro
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 2 (2023)
Epigenetic remodeling is a molecular hallmark of gliomas, and it has been identified as a key mediator of glioma progression. Epigenetic dysregulation contributes to gliomagenesis, tumor progression, and responses to immunotherapies, as well as deter
Externí odkaz:
https://doaj.org/article/6308066ce446495b9c5b231dbe2583e6
Autor:
Santiago Haase, Kaushik Banerjee, Anzar A. Mujeeb, Carson S. Hartlage, Fernando M. Núñez, Felipe J. Núñez, Mahmoud S. Alghamri, Padma Kadiyala, Stephen Carney, Marcus N. Barissi, Ayman W. Taher, Emily K. Brumley, Sarah Thompson, Justin T. Dreyer, Caitlin T. Alindogan, Maria B. Garcia-Fabiani, Andrea Comba, Sriram Venneti, Visweswaran Ravikumar, Carl Koschmann, Ángel M. Carcaboso, Maria Vinci, Arvind Rao, Jennifer S. Yu, Pedro R. Lowenstein, Maria G. Castro
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 22 (2022)
Pediatric high-grade gliomas (pHGGs) are the leading cause of cancer-related deaths in children in the USA. Sixteen percent of hemispheric pediatric and young adult HGGs encode Gly34Arg/Val substitutions in the histone H3.3 (H3.3-G34R/V). The mechani
Externí odkaz:
https://doaj.org/article/86291c23bf8d4ccda5764eae5949072f
Autor:
Maria B. Garcia-Fabiani, Santiago Haase, Andrea Comba, Stephen Carney, Brandon McClellan, Kaushik Banerjee, Mahmoud S. Alghamri, Faisal Syed, Padma Kadiyala, Felipe J. Nunez, Marianela Candolfi, Antonela Asad, Nazareno Gonzalez, Marisa E. Aikins, Anna Schwendeman, James J. Moon, Pedro R. Lowenstein, Maria G. Castro
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
High grade gliomas are malignant brain tumors that arise in the central nervous system, in patients of all ages. Currently, the standard of care, entailing surgery and chemo radiation, exhibits a survival rate of 14-17 months. Thus, there is an urgen
Externí odkaz:
https://doaj.org/article/e49bee1aa5e941549a4fe571f50575c6
Autor:
Mahmoud S. Alghamri, Brandon L. McClellan, Carson S. Hartlage, Santiago Haase, Syed Mohd Faisal, Rohit Thalla, Ali Dabaja, Kaushik Banerjee, Stephen V. Carney, Anzar A. Mujeeb, Michael R. Olin, James J. Moon, Anna Schwendeman, Pedro R. Lowenstein, Maria G. Castro
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Gliomas are one of the most lethal types of cancers accounting for ∼80% of all central nervous system (CNS) primary malignancies. Among gliomas, glioblastomas (GBM) are the most aggressive, characterized by a median patient survival of fewer than 1
Externí odkaz:
https://doaj.org/article/d0bcbb33bc1e4b30b99e75b5f849bf8c
Autor:
Kaushik Banerjee, Felipe J. Núñez, Santiago Haase, Brandon L. McClellan, Syed M. Faisal, Stephen V. Carney, Jin Yu, Mahmoud S. Alghamri, Antonela S. Asad, Alejandro J. Nicola Candia, Maria Luisa Varela, Marianela Candolfi, Pedro R. Lowenstein, Maria G. Castro
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Glioblastoma (GBM) is the most common and aggressive primary brain tumor in the adult population and it carries a dismal prognosis. Inefficient drug delivery across the blood brain barrier (BBB), an immunosuppressive tumor microenvironment (TME) and
Externí odkaz:
https://doaj.org/article/73be5c62624b42bbb8b526bca29c4b74
Autor:
Fernando M. Nunez, Jessica C. Gauss, Flor M. Mendez, Santiago Haase, Pedro R. Lowenstein, Maria G. Castro
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100165- (2020)
Summary: Brainstem gliomas are aggressive tumors that are more prevalent in pediatric patients. The location of these tumors makes them inoperable, and currently there is no effective treatment. Recent genomic data revealed the unique biology of thes
Externí odkaz:
https://doaj.org/article/a3db14a13d20490eab3edbf875097099
Publikováno v:
Viruses, Vol 7, Iss 5, Pp 2230-2267 (2015)
Baculoviruses are known to regulate many insect populations in nature. Their host-specificity is very high, usually restricted to a single or a few closely related insect species. They are amongst the safest pesticides, with no or negligible effects
Externí odkaz:
https://doaj.org/article/123b991573f548fbaea0aa82763b11c7
Autor:
Santiago Haase, Christina B. McCarthy, M. Leticia Ferrelli, Matias L. Pidre, Alicia Sciocco-Cap, Victor Romanowski
Publikováno v:
Viruses, Vol 7, Iss 4, Pp 1599-1612 (2015)
Anticarsia gemmatalis is an important pest in legume crops in South America and it has been successfully controlled using Anticarsia gemmatalis Multiple Nucleopolyhedrovirus (AgMNPV) in subtropical climate zones. Nevertheless, in temperate climates i
Externí odkaz:
https://doaj.org/article/03dddce385184904b3e30b1879178bc8
Autor:
Stephen V. Carney, Kaushik Banerjee, Anzar Mujeeb, Brandon Zhu, Santiago Haase, Maria L. Varela, Padma Kadiyala, Claire E. Tronrud, Ziwen Zhu, Devarshi Mukherji, Preethi Gorla, Yilun Sun, Rebecca Tagett, Felipe J. Núñez, Maowu Luo, Weibo Luo, Mats Ljungman, Yayuan Liu, Ziyun Xia, Anna Schwendeman, Tingting Qin, Maureen A. Sartor, Joseph F. Costello, Daniel P. Cahill, Pedro R. Lowenstein, Maria G. Castro
Publikováno v:
Clinical Cancer Research. 29:1763-1782
Purpose: Mutant isocitrate dehydrogenase 1 (mIDH1) alters the epigenetic regulation of chromatin, leading to a hypermethylation phenotype in adult glioma. This work focuses on identifying gene targets epigenetically dysregulated by mIDH1 to confer th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86ae6e6bd650e50ff11d9a3202477c21
https://doi.org/10.1158/1078-0432.ccr-22-1896
https://doi.org/10.1158/1078-0432.ccr-22-1896
Publikováno v:
Neuro-Oncology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d938522982b64d6e8c2776b93d353bec
https://doi.org/10.1093/neuonc/noad090
https://doi.org/10.1093/neuonc/noad090