Neutrophil subtypes shape HIV-specific CD8 T-cell responses after vaccinia virus infection

Autor: Mauro Di Pilato, Miguel Palomino-Segura, Ernesto Mejías-Pérez, Carmen E. Gómez, Andrea Rubio-Ponce, Rocco D’Antuono, Diego Ulisse Pizzagalli, Patricia Pérez, Raphael Kfuri-Rubens, Alberto Benguría, Ana Dopazo, Iván Ballesteros, Carlos Oscar S. Sorzano, Andrés Hidalgo, Mariano Esteban, Santiago F. Gonzalez

Publikováno v: npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)

Abstract Neutrophils are innate immune cells involved in the elimination of pathogens and can also induce adaptive immune responses. Nα and Nβ neutrophils have been described with distinct in vitro capacity to generate antigen-specific CD8 T-cell r

Externí odkaz: https://doaj.org/article/89b84f82228e4bf9963a98f0174b37ad

ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens

Autor: Michele Proietti, Lisa Perruzza, Daniela Scribano, Giovanni Pellegrini, Rocco D’Antuono, Francesco Strati, Marco Raffaelli, Santiago F. Gonzalez, Marcus Thelen, Wolf-Dietrich Hardt, Emma Slack, Mauro Nicoletti, Fabio Grassi

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

The generation of protective secretory IgA is a desired outcome of oral vaccination. Here, the authors show that the depletion of intestinal ATP significantly improves the production and response of high-affinity IgA against both live and inactivated

Externí odkaz: https://doaj.org/article/e0e24831b05347f7a1b912b1db0a67fd

Characterization of the Dynamic Behavior of Neutrophils Following Influenza Vaccination

Autor: Diego Ulisse Pizzagalli, Irene Latino, Alain Pulfer, Miguel Palomino-Segura, Tommaso Virgilio, Yagmur Farsakoglu, Rolf Krause, Santiago F. Gonzalez

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Neutrophils are amongst the first cells to respond to inflammation and infection. Although they play a key role in limiting the dissemination of pathogens, the study of their dynamic behavior in immune organs remains elusive. In this work, we charact

Externí odkaz: https://doaj.org/article/ecba12007d95408fac8348c945273155

Data from Subcapsular Sinus Macrophages Promote Melanoma Metastasis to the Sentinel Lymph Nodes via an IL1α–STAT3 Axis

Autor: Santiago F. Gonzalez, Francesco Bertoni, Ron N. Apte, Silvia Monticelli, Elena Voronov, Lorenzo Mortara, Antonino Bruno, Robert E. Hunger, Fausto Sessa, Anna Maria Chiaravalli, Ivo Kwee, Aner Ottolenghi, Marina Bersudsky, S. Morteza Seyed Jafari, Diego Morone, Alberto J. Arribas, Andrea Rinaldi, Murodzhon Akhmedov, Cristina Leoni, Daniel Molina Romero, Irene Latino, Giulio Sartori, Luciano Cascione, Joy Bordini, Tommaso Virgilio

During melanoma metastasis, tumor cells originating in the skin migrate via lymphatic vessels to the sentinel lymph node (sLN). This process facilitates tumor cell spread across the body. Here, we characterized the innate inflammatory response to mel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f9251053f9675706017bf20c384bc43
https://doi.org/10.1158/2326-6066.c.6551081

Subcapsular sinus macrophages promote melanoma metastasis to the sentinel lymph nodes via an IL-1α-STAT3 axis

Autor: Tommaso Virgilio, Joy Bordini, Luciano Cascione, Giulio Sartori, Irene Latino, Daniel Molina Romero, Cristina Leoni, Murodzhon Akhmedov, Andrea Rinaldi, Alberto J. Arribas, Diego Morone, S. Morteza Seyed Jafari, Marina Bersudsky, Aner Ottolenghi, Ivo Kwee, Anna Maria Chiaravalli, Fausto Sessa, Robert E. Hunger, Antonino Bruno, Lorenzo Mortara, Elena Voronov, Silvia Monticelli, Ron N. Apte, Francesco Bertoni, Santiago F. Gonzalez

Publikováno v: Virgilio, Tommaso; Bordini, Joy; Cascione, Luciano; Sartori, Giulio; Latino, Irene; Molina Romero, Daniel; Leoni, Cristina; Akhmedov, Murodzhon; Rinaldi, Andrea; Arribas, Alberto J; Morone, Diego; Seyed Jafari, S Morteza; Bersudsky, Marina; Ottolenghi, Aner; Kwee, Ivo; Chiaravalli, Anna Maria; Sessa, Fausto; Hunger, Robert E; Bruno, Antonino; Mortara, Lorenzo; ... (2022). Subcapsular sinus macrophages promote melanoma metastasis to the sentinel lymph nodes via an IL-1α-STAT3 axis. Cancer immunology research, 10(12), pp. 1525-1541. American Association for Cancer Research 10.1158/2326-6066.CIR-22-0225

During melanoma metastasis, tumor cells originating in the skin migrate via lymphatic vessels to the sentinel lymph node (sLN). This process facilitates tumor cell spread across the body. Here, we characterized the innate inflammatory response to mel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c81f2e6b1edff225c9969026c8f42d