Výsledky vyhledávání - "Santiago E. Werbajh"

TNF-α enhances estrogen-induced cell proliferation of estrogen-dependent breast tumor cells through a complex containing nuclear factor-kappa B

Autor: Santiago E. Werbajh, Monica Alejandra Costas, Georgina Pamela Colo, Maria Fernanda Rubio, E G A Cafferata, Victor E. Nahmod, Edith C. Kordon, A Quaglino, I M Nojek

Publikováno v: Oncogene. 25:1367-1377

Breast tumors are usually classified according to their response to estrogens as hormone-dependent or -independent. In this work, we investigated the role of the proinflammatory cytokine TNF-alpha on the estrogen-receptor-positive T47D breast ductal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adcb3c163e658a26257fcf3f2659f6e7
https://doi.org/10.1038/sj.onc.1209176

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La actividad transcripcional de NF-kB es diferencialmente regulada por dominios especificos del coactivador TIF2 Different enzymatic activities recruitment by specific domains of TIF2 are involved in NF-kB transactivation

Autor: Ignacio M. Nojek, Santiago E. Werbajh, Georgina P. Colo, Fernanda M. Rubio, Lorena D. Franco, Víctor E. Nahmod, Mónica A. Costas

Publikováno v: Medicina (Buenos Aires), Vol 64, Iss 2, Pp 135-138 (2004)

Demostramos previamente que la sobreexpresión de coactivadores de receptores nucleares aumenta la actividad NF-kB en forma dosis dependiente. Se estudió el mecanismo por el cual el coactivador TIF2 regula la actividad de NF-kB. Determinamos que: 1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::6828e8fef1f9b70e895acef3fb7ab433
http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0025-76802004000200008

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Antagonistic effects of T-Ag and VP16 reveal a role for RNA pol II elongation on alternative splicing

Autor: Juan Pablo Fededa, Manuel de la Mata, Demián Cazalla, Sebastian Kadener, Paula Cramer, Guadalupe Nogués, Anabella Srebrow, Alberto R. Kornblihtt, Santiago E. Werbajh

Publikováno v: The EMBO Journal. 20:5759-5768

Here we investigate the promoter control of alternative splicing by studying two transcriptional activators on templates under replicating conditions. SV40 large T-antigen (T-Ag) activates template replication only 2-fold but transcription 25-fold. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa874f203d183516e33a0df370e84296
https://doi.org/10.1093/emboj/20.20.5759

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RAC-3 is a NF-κB coactivator

Autor: Santiago E. Werbajh, Mónica A. Costas, Rainer B. Lanz, Ignacio Nojek

Publikováno v: FEBS Lett. 2000;485(2-3):195-199
Biblioteca Digital (UBA-FCEN)
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN

It has been shown that the molecular mechanism by which cytokines and glucocorticoids mutually antagonize their functions involves a mutual glucocorticoid receptor (GR)/nuclear factor-κB (NF-κB) transrepression. Here we report a role for the nuclea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b70519cc8841ce45faba02b3613776
https://doi.org/10.1016/s0014-5793(00)02223-7

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Involvement of fibronectin in the regulation of urokinase production and binding in murine mammary tumor cells

Autor: Elisa Bal de Kier Joffé, Lydia Puricelli, Santiago E. Werbajh, Andrés F. Muro, Alejandro J. Urtreger, Julio A. Aguirre Ghiso

Publikováno v: International Journal of Cancer. 82:748-753

Tumor invasion and metastasis development is a multistep process involving adhesion molecules as well as tumor proteases. It has been reported that tumor cells lacking fibronectin (FN) expression and engineered to re-express FN showed a marked reduct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cce6db22146e08497325e9050c98c963
https://doi.org/10.1002/(sici)1097-0215(19990827)82:5<748::aid-ijc20>3.0.co

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Expression of RGD minus fibronectin that does not form extracellular matrix fibrils is sufficient to decrease tumor metastasis

Autor: Santiago E. Werbajh, Lydia Puricelli, Elisa Bal de Kier Joffé, Alberto R. Kornblihtt, Andrés F. Muro, Fabiola Porro, Francisco E. Baralle, Alejandro J. Urtreger

Publikováno v: International Journal of Cancer. 78:233-241

Fibronectin (FN) is a plasma and extracellular matrix (ECM) glycoprotein, the expression of which may modulate the invasive and metastatic abilities of cancer cells. LMM3 is a cell line derived from the highly metastatic mouse mammary adenocarcinoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2187b99c641cf8dd7500c795cbccf7b
https://doi.org/10.1002/(sici)1097-0215(19981005)78:2<233::aid-ijc18>3.0.co

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The p160 nuclear receptor co-activator RAC3 exerts an anti-apoptotic role through a cytoplasmatic action

Autor: Monica Alejandra Costas, Georgina Pamela Colo, Victor E. Nahmod, Santiago E. Werbajh, Cecilia Viviana Alvarado, I M Nojek, Mario D. Galigniana, Maria Fernanda Rubio, Pablo Christian Echeverria

Publikováno v: Oncogene. 27(17)

The p160 nuclear receptor coactivators represent a family of molecules, which are recruited by steroid nuclear receptors as well as other transcription factors that are over-expressed in several tumors. We investigated the role of one member of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f69772b478cb15897c537d70d628a651
https://pubmed.ncbi.nlm.nih.gov/17968310

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Fibronectin is distinctly downregulated in murine mammary adenocarcinoma cells with high metastatic potential

Autor: Frank Verrecchia, Alejandro J. Urtreger, Alain Mauviel, Elisa Bal de Kier Joffé, Santiago E. Werbajh, Alberto R. Kornblihtt, Lydia Puricelli

Publikováno v: Oncology Reports.

In the present work we used a murine mammary cancer model of two related adenocarcinomas with different lung metastasizing abilities, to compare their global gene expression profiles. Clontech Atlas mouse cDNA microarrays of primary cultured tumor ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24f9e9c08299270e216d0cb56bd12030
https://doi.org/10.3892/or.16.6.1403

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Fibronectin is distinctly downregulated in murine mammary adenocarcinoma cells with high metastatic potential

Autor: Alejandro J, Urtreger, Santiago E, Werbajh, Frank, Verrecchia, Alain, Mauviel, Lydia I, Puricelli, Alberto R, Kornblihtt, Elisa D, Bal de Kier Joffé

Publikováno v: Oncology reports. 16(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e881abab609fbf587f52d8b8ce703aa4
https://pubmed.ncbi.nlm.nih.gov/17089068

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[Different enzymatic activities recruitment by specific domains of TIF2 are involved in NF-kappaB transactivation]

Autor: Ignacio M, Nojek, Santiago E, Werbajh, Georgina P, Colo, Fernanda M, Rubio, Lorena D, Franco, Victor E, Nahmod, Monica A, Costas

Publikováno v: Medicina. 64(2)

We have previously shown that nuclear receptor coactivator overexpression significantly enhanced NF-kappaB activity in a dose response manner. We studied the mechanism by which TIF2 regulates NF-kappaB activity. We determined that: 1) the p38 specifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9622a292efd5625cd446511344bafb06
https://pubmed.ncbi.nlm.nih.gov/15628300

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