Výsledky vyhledávání - "Santi Suryani Chen"

Abstract 5198: Humanized mice for preclinical efficacy evaluation of drugs targeting GARP

Autor: Xing Liu, Meirong Wu, Huiyi Wang, Weiwei Yu, Jianming Xu, Hongyan Sun, Cunxiang Ju, Hongyu Wang, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao

Publikováno v: Cancer Research. 83:5198-5198

Introduction: GARP (Glycoprotein-A repetitions predominant) is a cell surface receptor which is coded by Lrrc32 (Leucine rich repeat containing protein 32) and involved in the activation of TGF-beta. The expression of GARP has been widely found in va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1385aa4212456270086a2aba3edeecc
https://doi.org/10.1158/1538-7445.am2023-5198

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Abstract 4472: A mouse model for GvHD: an excellent tool for evaluating the efficacy of anti-GvHD drugs and testing mechanisms of immunoregulation

Autor: Meirong Wu, Shiru Zhang, Fang Zhu, Hongyan Sun, Jianming Xu, Cunxiang Ju, Hongyu Wang, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao

Publikováno v: Cancer Research. 83:4472-4472

Hematological malignancies, including leukemia, lymphoma and multiple myeloma, account for about 7% of all newly diagnosed cancers. Allogeneic hematopoietic stem cell transplantation (HSCT) is a traditional treatment for hematologic malignancies. Cur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5366fe13d3961570901f62b8b622e03
https://doi.org/10.1158/1538-7445.am2023-4472

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Abstract 5199: B7-H3 & PD-L1 double-humanized BALB/c mouse: a novel animal model for preclinical studies of human B7-H3 antibodies or bispecific antibodies

Autor: Shiying Guo, Lingyu Song, Xin Qin, Jianming Xu, Hongyan Sun, Cunxiang Ju, Hongyu Wang, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao

Publikováno v: Cancer Research. 83:5199-5199

Immune checkpoint molecule B7-H3, also known as CD276, is a member of the B7-CD28 family of immunomodulatory proteins. It is a type I membrane protein with sequence similarities to the extracellular domain of programmed death-ligand 1 (PD-L1). B7-H3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db021cd7431e9f8ade2438bb2f862ea4
https://doi.org/10.1158/1538-7445.am2023-5199

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Abstract 5202: NCG-M humanized mice: an excellent model for human immune reconstitution of myeloid lineages

Autor: Huiyi Wang, Jialu Fan, Shiying Guo, Mingkun Zhang, Shuai Li, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao, Cunxiang Ju

Publikováno v: Cancer Research. 83:5202-5202

Severe immunodeficient mice engrafted with human hematopoietic stem cells (HSC) have been extensively used in immuno-oncology related studies to evaluate the efficacy of cancer therapies. However, because of species differences, murine cytokines prov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad52e74b7b180b3286ed0c2183242d3c
https://doi.org/10.1158/1538-7445.am2023-5202

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Abstract 3242: Efficacy evaluation by novel humanized mouse models for preclinical study of ADCs combined with immunotherapy

Autor: Fang Zhu, Hongyan Sun, Qian Lu, Yuan Fang, Jianming Xu, Cunxiang Ju, Hongyu Wang, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao

Publikováno v: Cancer Research. 83:3242-3242

Antibody-drug conjugates (ADCs) are effective anti-tumor therapies with high specificity, with little toxicity and side effects. Xenograft tumor models based on immunodeficient mice have been used for evaluating the human anti-tumor efficacy of ADCs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::603368ff8f578a7b64695fe227baeb0b
https://doi.org/10.1158/1538-7445.am2023-3242

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Abstract 5192: NCG-MHC-dKO mice: an excellent model for PBMC reconstitution and pharmacodynamic evaluation in the absence of GvHD

Autor: Huiyi Wang, Jun Xing, Jialu Fan, Huanhuan Hou, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao, Cunxiang Ju

Publikováno v: Cancer Research. 83:5192-5192

Human immune cell reconstitution (PBMC or CD34+ hematopoietic stem cell; HSC) is commonly performed in immunodeficient mouse strains such as NCG, NSG, or NOG. The use of PBMC is preferred for multiple reasons, including faster engraftment, lower cost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04e13bd64795e20b6911a077a54525ec
https://doi.org/10.1158/1538-7445.am2023-5192

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Abstract 5205: B6-KrasLSL-G12C mouse model for assessing the occurrence and development of lung and pancreatic cancer tumors

Autor: Xiaoliu Yang, Yunlong Jiang, Xue Wu, Mingkun Zhang, Jing Zhao, Santi Suryani Chen, Zhiying Li, Erica Trujillo, Mark Wade Moore, Xiang Gao, Cunxiang Ju

Publikováno v: Cancer Research. 83:5205-5205

In May 2021, the FDA approved sotorasib (Lumakras™) as the first treatment for adult patients with non-small cell lung cancer (NSCLC) harboring the KRASG12C genetic mutation. To study the relationship between the mutational activation of KRAS and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e284f3c2cad0b3eb6649bd2adb3cd6b
https://doi.org/10.1158/1538-7445.am2023-5205

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