Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Santhosh Satapati"'
Autor:
Santhosh Satapati, Daniel P. Downes, Daniel Metzger, Harish Shankaran, Saswata Talukdar, Yingjiang Zhou, Zhao Ren, Michelle Chen, Yeon-Hee Lim, Nathan G. Hatcher, Xiujuan Wen, Payal R. Sheth, David G. McLaren, Stephen F. Previs
Publikováno v:
SLAS Discovery, Vol 27, Iss 1, Pp 20-28 (2022)
Screening campaigns, especially those aimed at modulating enzyme activity, often rely on measuring substrate→product conversions. Unfortunately, the presence of endogenous substrates and/or products can limit one's ability to measure conversions. A
Externí odkaz:
https://doaj.org/article/103ba40a3e5a45859c5af8ed7bf87a21
Autor:
Santhosh Satapati, Ying Qian, Margaret S. Wu, Aleksandr Petrov, Ge Dai, Sheng-ping Wang, Yonghua Zhu, Xiaolan Shen, Eric S. Muise, Ying Chen, Emanuel Zycband, Adam Weinglass, Jerry Di Salvo, John S. Debenham, Jason M. Cox, Ping Lan, Vinit Shah, Stephen F. Previs, Mark Erion, David E. Kelley, Liangsu Wang, Andrew D. Howard, Jin Shang
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 8, Pp 1561-1578 (2017)
GPR40 and GPR120 are fatty acid sensors that play important roles in glucose and energy homeostasis. GPR40 potentiates glucose-dependent insulin secretion and demonstrated in clinical studies robust glucose lowering in type 2 diabetes. GPR120 improve
Externí odkaz:
https://doaj.org/article/1d5d6bb81f4b48f7aa3c095bb5ab4e88
Autor:
Blanka Kucejova, Joao Duarte, Santhosh Satapati, Xiaorong Fu, Olga Ilkayeva, Christopher B. Newgard, James Brugarolas, Shawn C. Burgess
Publikováno v:
Cell Reports, Vol 16, Iss 2, Pp 508-519 (2016)
Dysregulated mitochondrial metabolism during hepatic insulin resistance may contribute to pathophysiologies ranging from elevated glucose production to hepatocellular oxidative stress and inflammation. Given that obesity impairs insulin action but pa
Externí odkaz:
https://doaj.org/article/5e7e5351d51a49cfa2e596ec11fa5ddf
Autor:
Vijay R More, Julie Lao, David G McLaren, Anne-Marie Cumiskey, Beth Ann Murphy, Ying Chen, Stephen Previs, Steven Stout, Rajesh Patel, Santhosh Satapati, Wenyu Li, Edward Kowalik, Daphne Szeto, Andrea Nawrocki, Alessandro Pocai, Liangsu Wang, Paul Carrington
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186586 (2017)
Lipid lowering properties of glucagon have been reported. Blocking glucagon signaling leads to rise in plasma LDL levels. Here, we demonstrate the lipid lowering effects of acute dosing with Glp1r/Gcgr dual agonist (DualAG). All the experiments were
Externí odkaz:
https://doaj.org/article/610ce14e40dc429c826400d13e869211
Autor:
Santhosh Satapati, Nishanth E. Sunny, Blanka Kucejova, Xiaorong Fu, Tian Teng He, Andrés Méndez-Lucas, John M. Shelton, Jose C. Perales, Jeffrey D. Browning, Shawn C. Burgess
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 6, Pp 1080-1092 (2012)
The manner in which insulin resistance impinges on hepatic mitochondrial function is complex. Although liver insulin resistance is associated with respiratory dysfunction, the effect on fat oxidation remains controversial, and biosynthetic pathways t
Externí odkaz:
https://doaj.org/article/ba94d3a6be124555b8986617945852ef
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 3, Pp 577-586 (2012)
Fasting promotes triglyceride (TG) accumulation in lean tissues of some animals, but the effect in humans is unknown. Additionally, fasting lipolysis is sexually dimorphic in humans, suggesting that lean tissue TG accumulation and metabolism may diff
Externí odkaz:
https://doaj.org/article/07ed2735d1f04be6911ba0cdb43dd8f5
Autor:
Wendy Zhong, David G. McLaren, Daniel Metzger, Ji Zhang, Daniel P. Downes, Payal R. Sheth, Saswata Talukdar, Julie Lao, Guillermo Godinez, Santhosh Satapati, Stephen F. Previs, Bingming Chen
Publikováno v:
Journal of the American Society for Mass Spectrometry. 31:2421-2425
Spatial characterization of triglyceride metabolism is an area of significant interest which can be enabled by mass spectrometry imaging via recent advances in neutral lipid laser desorption analytical approaches. Here, we extend recent advancements
Autor:
Michael D. Bereket, Francesco Paolo Casale, Lorn Kategaya, Anna Shcherbina, Navpreet Ranu, Alicia Lee, Kelly Haston, Rohit Loomba, Arun Sanyal, Stephen Harrison, Zobair Younossi, Catherine Jia, David Lopez, Li Li, Robert Myers, David Breckinridge, Andrew Billin, Ellen Berg, Santhosh Satapati, Eilon Sharon, Theofanis Karaletsos, Daphne Koller, Matthew Albert
Publikováno v:
Journal of Hepatology. 77:S31
Autor:
Xiujuan Wen, Kiersten Tovar, Gregory O'Donnell, Santhosh Satapati, Chang Liu, Lucien P. Ghislain, Steven J. Stout, Steven Cifelli, Vinit Shah, Kevin P. Bateman, Payal R. Sheth, Sammy S Datwani, David G. McLaren, Mary Jo Wildey, Thomas R. Covey
Publikováno v:
Analytical chemistry. 93(15)
The primary goal of high-throughput screening (HTS) is to rapidly survey a broad collection of compounds, numbering from tens of thousands to millions of members, and identify those that modulate the activity of a therapeutic target of interest. For
Autor:
Ying Li, Renato Felipe Pereira, J. Alan Maschek, Joseph L. Wilkerson, Annelise M Poss, Scott A. Summers, Vincent A. Kaddai, David E. Kelley, Xiaolan Shen, William L. Holland, Doris Hissako Sumida, Jared Rutter, Margaret Wu, Ying Qian, Jun Yao, Aleksandr Petrov, Graeme I. Lancaster, David G. McLaren, Trevor S. Tippetts, Liangsu Wang, Santhosh Satapati, Mackenzie J. Pearson, Christian N. Nunes, Rafael Mayoral Monibas, Heather Zhou, Liping Wang, Monowarul Mobin Siddique, Mark D. Erion, Stephen F. Previs, Bhagirath Chaurasia, C. Rufus Sweeney, Jinqi Liu, Ying Chen, James E. Cox, Andrew D. Howard
Publikováno v:
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Science
Made available in DSpace on 2019-10-06T17:15:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-07-26 American Diabetes Association American Heart Association Ben B. and Iris M. Margolis Foundation Diabetes Research Center, University of Washi