Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Santhosh Palani"'
Autor:
Santhosh Palani, Casim A. Sarkar
Publikováno v:
Cell Reports, Vol 1, Iss 3, Pp 215-224 (2012)
Progenitor cells within a clonal population show variable proclivity toward lineage commitment and differentiation. This cell-to-cell variability has been attributed to transcriptome-wide gene expression noise generated by fluctuations in the amount
Externí odkaz:
https://doaj.org/article/fdcb14701e014238bab6559e1ae22ea4
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 4, Pp 826-836 (2007)
Obesity-related increase in body fat mass is a risk factor for many diseases, including type 2 diabetes. Controlling adiposity by targeted modulation of adipocyte enzymes could offer an attractive alternative to current dietary approaches. Brown adip
Externí odkaz:
https://doaj.org/article/eb3fe35a1b464315aa00f3f582cb0d79
Autor:
Mayankbhai Patel, Santhosh Palani, Arijit Chakravarty, Johnny Yang, Wen Chyi Shyu, Jerome T Mettetal
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109892 (2014)
Toxicity often limits the utility of oncology drugs, and optimization of dose schedule represents one option for mitigation of this toxicity. Here we explore the schedule-dependency of neutropenia, a common dose-limiting toxicity. To this end, we ana
Externí odkaz:
https://doaj.org/article/e467ffe512984529900d7eebfdaf78a1
Autor:
Santhosh Palani, Casim A Sarkar
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 9, p e1000518 (2009)
Autoregulation of transcription factors and cross-antagonism between lineage-specific transcription factors are a recurrent theme in cell differentiation. An equally prevalent event that is frequently overlooked in lineage commitment models is the up
Externí odkaz:
https://doaj.org/article/109505e8a4aa4747ab26acea6e9c2358
Publikováno v:
The AAPS journal. 24(4)
Antibody–drug conjugates (ADCs) comprise 3 distinct parts: a specific antibody carrier (mAb), a linker, and a cytotoxic payload. Typical pharmacokinetic (PK) characterization of ADCs remains fragmented using separate noncompartmental analyses (NCA)
Publikováno v:
Journal of Clinical Oncology. 40:e15005-e15005
e15005 Background: PK characterization of ADCs is often fragmented using separate analyses of individual analytes. As such it is difficult to compare among ADCs in terms of PK characteristics critical for understanding the fate of an ADC complex as a
Autor:
Andrew X. Chen, Arijit Chakravarty, Christopher J. Zopf, Wen Chyi Shyu, Joseph B. Bolen, Jerome T. Mettetal, Santhosh Palani
BackgroundThe effectiveness of many targeted therapies is limited by toxicity and the rise of drug resistance. A growing appreciation of the inherent redundancies of cancer signaling has led to a rise in the number of combination therapies under deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0eb07124c0dce12d7ec53255c1334c5
https://doi.org/10.1101/2020.07.01.159657
https://doi.org/10.1101/2020.07.01.159657
Publikováno v:
The EMBO Journal. 31:3821-3832
Endogenous small interfering RNAs (endo-siRNAs) have been discovered in many organisms, including mammals. In C. elegans, depletion of germline-enriched endo-siRNAs found in complex with the CSR-1 Argonaute protein causes sterility and defects in chr
Autor:
Casim A. Sarkar, Santhosh Palani
Publikováno v:
Cell Reports, Vol 1, Iss 3, Pp 215-224 (2012)
Summary Progenitor cells within a clonal population show variable proclivity toward lineage commitment and differentiation. This cell-to-cell variability has been attributed to transcriptome-wide gene expression noise generated by fluctuations in the
Publikováno v:
Cell. 144(1):119-131
SUMMARY The flexibility of MAPK cascade responses enables regulation of a vast array of cell fate decisions, but elucidating the mechanisms underlying this plasticity is difficult in endogenous signaling networks. We constructed insulated mammalian M