Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Santhosh Kumar Ghadge"'
Autor:
Marc-Michael Zaruba, Simon Staggl, Santhosh Kumar Ghadge, Thomas Maurer, Jasmina Gavranovic-Novakovic, Vivek Jeyakumar, Patric Schönherr, Andreas Wimmer, Gerhard Pölzl, Axel Bauer, Moritz Messner
Publikováno v:
Cells, Vol 13, Iss 13, p 1074 (2024)
Activation of the CXCL12/CXCR4/ACKR3 axis is known to aid myocardial repair through ischemia-triggered hypoxia-inducible factor-1α (HIF-1α). To enhance the upregulation of HIF-1α, we administered roxadustat, a novel prolyl hydroxylase inhibitor (P
Externí odkaz:
https://doaj.org/article/fa27c5de99a142788d29eb4235130afd
Autor:
Santhosh Kumar Ghadge, Moritz Messner, Herbert Seiringer, Thomas Maurer, Simon Staggl, Tanja Zeller, Christian Müller, Daniela Börnigen, Wolfgang J. Weninger, Stefan H. Geyer, Sieghart Sopper, Anne Krogsdam, Gerhard Pölzl, Axel Bauer, Marc-Michael Zaruba
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5908 (2021)
The chemokine CXCL12 plays a fundamental role in cardiovascular development, cell trafficking, and myocardial repair. Human genome-wide association studies even have identified novel loci downstream of the CXCL12 gene locus associated with coronary a
Externí odkaz:
https://doaj.org/article/d570ff605ead42ca945415642fb45b2c
Autor:
Christina Manakanatas, Santhosh Kumar Ghadge, Azra Agic, Fatih Sarigol, Petra Fichtinger, Irmgard Fischer, Roland Foisner, Selma Osmanagic-Myers
Publikováno v:
Aging (Albany NY)
Endothelial defects significantly contribute to cardiovascular pathology in the premature aging disease Hutchinson-Gilford progeria syndrome (HGPS). Using an endothelium-specific progeria mouse model, we identify a novel, endothelium-specific microRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164366cc8189269bf555e5916bae4bee
http://europepmc.org/articles/PMC8791216
http://europepmc.org/articles/PMC8791216
Autor:
Moritz Messner, Santhosh Kumar Ghadge, Thomas Maurer, Michael Graber, Simon Staggl, Sarah Christine Maier, Gerhard Pölzl, Marc-Michael Zaruba
Publikováno v:
Cells, Vol 9, Iss 9, p 1981 (2020)
Lamins are important filaments forming the inner nuclear membrane. Lamin A is processed by zinc metalloproteinase (ZMPSTE24). Failure to cleave a truncated form of prelamin A—also called progerin—causes Hutchinson–Gilford progeria syndrome a we
Externí odkaz:
https://doaj.org/article/1ab907d1b5cc4071aa35d2239a78c3aa
Autor:
Moritz Messner, Santhosh Kumar Ghadge, Valentina Goetsch, Andreas Wimmer, Jakob Dörler, Gerhard Pölzl, Marc-Michael Zaruba
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0196739 (2018)
Mutations in the LMNA gene are a common cause (6-8%) of dilated cardiomyopathy (DCM) leading to heart failure, a growing health care problem worldwide. The premature aging disease Hutchinson-Gilford syndrome (HGPS) is also caused by defined mutations
Externí odkaz:
https://doaj.org/article/954ee0c380b24b74b1917793913c564d
Autor:
Moritz Messner, Santhosh Kumar Ghadge, Thomas Schuetz, Herbert Seiringer, Gerhard Pölzl, Marc-Michael Zaruba
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 8, p 1976 (2019)
Obesity is a well-described risk factor resulting in premature aging of the cardiovascular system ultimately limiting longevity. Premature cardiac death and aging is the hallmark of Hutchinson–Gilford syndrome (HGPS), a disease caused by defined mu
Externí odkaz:
https://doaj.org/article/3bdc1146e5fe42f4873a0ee8e2b5807d
Autor:
Wolfgang-Michael Franz, Moritz Messner, Maximilian Doppelhammer, Andreas Petry, Britta Husse, Marc-Michael Zaruba, Thi Van Pham, Santhosh Kumar Ghadge, Agnes Görlach
Publikováno v:
Journal of Molecular Medicine (Berlin, Germany)
SDF-1/CXCR4 activation facilitates myocardial repair. Therefore, we aimed to activate the HIF-1α target genes SDF-1 and CXCR4 by dimethyloxalylglycine (DMOG)-induced prolyl-hydroxylase (PH) inhibition to augment CXCR4+ cell recruitment and myocardia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93be8f7b3c49346f31e2ca35173dd086
https://doi.org/10.1007/s00109-017-1543-3
https://doi.org/10.1007/s00109-017-1543-3
Autor:
Herbert Seiringer, Gerhard Pölzl, Santhosh Kumar Ghadge, Marc-Michael Zaruba, Thomas Schuetz, Moritz Messner
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 8
International Journal of Molecular Sciences, Vol 20, Iss 8, p 1976 (2019)
Volume 20
Issue 8
International Journal of Molecular Sciences, Vol 20, Iss 8, p 1976 (2019)
Obesity is a well-described risk factor resulting in premature aging of the cardiovascular system ultimately limiting longevity. Premature cardiac death and aging is the hallmark of Hutchinson&ndash
Gilford syndrome (HGPS), a disease caused by d
Gilford syndrome (HGPS), a disease caused by d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146b7ef5c3a67441bb2ab08d2a69a80d
http://europepmc.org/articles/PMC6515652
http://europepmc.org/articles/PMC6515652
Publikováno v:
European Heart Journal. 38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59ae633ffafc0c658a10d1f236db2e35
https://doi.org/10.1093/eurheartj/ehx502.p1608
https://doi.org/10.1093/eurheartj/ehx502.p1608
Autor:
Johan Duchene, Anne Järve, Elena Popova, Santhosh Kumar Ghadge, Thoralf Niendorf, Andreas Pohlmann, Cemil Özcelik, Fatimunnisa Qadri, Silke Mühlstedt, Michael Bader, Philipp Boyé, Larisa Vilianovich
Publikováno v:
Journal of molecular medicine (Berlin, Germany). 94(9)
The chemokine CXCL12/SDF-1 is crucial for heart development and affects cardiac repair processes due to its ability to attract leukocytes and stem cells to injured myocardium. However, there is a great controversy whether CXCL12 is beneficial or detr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee8d70dce198f74f3536f03c11cfc7f
https://pubmed.ncbi.nlm.nih.gov/27251706
https://pubmed.ncbi.nlm.nih.gov/27251706